Investigating the Genomic Background of CRISPR-Cas Genomes for CRISPR-Based Antimicrobials [PDF]
Evolutionary Bioinformatics, 2022 CRISPR-Cas systems are an adaptive immunity that protects prokaryotes against foreign genetic elements. Genetic templates acquired during past infection events enable DNA-interacting enzymes to recognize foreign DNA for destruction.
Hyunjin Shim
doaj +2 more sources
Effect of migration in a diffusion model for template coexistence in protocells [PDF]
Bulletin of Mathematical Biology 76 (2014) 654-672, 2014 The compartmentalization of distinct templates in protocells and the exchange of templates between them (migration) are key elements of a modern scenario for prebiotic evolution.
Fontanari, Jose F., Serva, Maurizio
core +3 more sources
Experiments in Linear Template Combination using Genetic Algorithms [PDF]
arXiv, 2016 6 ...
Bhatnagar, Nikhilesh, Mamidi, Radhika
openaire +3 more sources
A C++ Template Library for Efficient Forward-Time Population Genetic Simulation of Large Populations [PDF]
Genetics, 2014 Abstract fwdpp is a C++ library of routines intended to facilitate the development of forward-time simulations under arbitrary mutation and fitness models. The library design provides a combination of speed, low memory overhead, and modeling flexibility not currently available from other forward simulation tools.
openaire +7 more sources
Explorations on template-directed genetic repair using ancient ancestors and other templates [PDF]
Proceedings of the 13th annual conference companion on Genetic and evolutionary computation, 2011 Handling constraints for combinatorial optimization problems is a classic challenge faced by genetic and evolutionary algorithms. This paper explores a naturally inspired genetic repair process to enforce constraints on evolutionary search. Lolle et al.
Hatton, Donagh, O'Donoghue, Diarmuid
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Co-design, implementation, and evaluation of plain language genomic test reports
npj Genomic Medicine, 2022 Understanding and communicating genomic results can be challenging for families and health professionals without genetic specialty training. Unlike modifying existing laboratory reports, plain language genomic test reports provide an opportunity for ...
Gemma R. Brett +8 more
doaj +1 more source
Template-directed synthesis of a genetic polymer in a model protocell [PDF]
Nature, 2008 Contemporary phospholipid-based cell membranes are formidable barriers to the uptake of polar and charged molecules ranging from metal ions to complex nutrients. Modern cells therefore require sophisticated protein channels and pumps to mediate the exchange of molecules with their environment.
Mansy, Sheref Samir +5 more
openaire +4 more sources
Protecting linear DNA templates in cell-free expression systems from diverse bacteria.
ACS Synthetic Biology, 2020 Recent advances in cell-free systems have opened up new capabilities in synthetic biology from rapid prototyping of genetic circuits and metabolic pathways to portable diagnostics and biomanufacturing.
S. Yim +3 more
semanticscholar +1 more source
Extensive recombination due to heteroduplexes generates large amounts of artificial gene fragments during PCR. [PDF]
PLoS ONE, 2014 Artificial recombinants can be generated during PCR when more than two genetically distinct templates coexist in a single PCR reaction. These recombinant amplicons can lead to the false interpretation of genetic diversity and incorrect identification of ...
Jia Liu +6 more
doaj +1 more source
Prime Editing: Genome Editing for Rare Genetic Diseases Without Double-Strand Breaks or Donor DNA
Frontiers in Genetics, 2020 An article published in Nature (Anzalone et al., 2019) reports the development of a genome editing experimental approach that mediates all possible base-to-base conversions, “indels,” and combinations in human genome without the need of double-strand ...
I. Matsoukas
semanticscholar +1 more source