Results 21 to 30 of about 119,454 (267)
An unbiased template of the Drosophila brain and ventral nerve cord.
PLoS ONE, 2020 The fruit fly Drosophila melanogaster is an important model organism for neuroscience with a wide array of genetic tools that enable the mapping of individual neurons and neural subtypes.
John A Bogovic +10 more
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Frontiers in Molecular Biosciences, 2023 Determining the three-dimensional structure of proteins in their native functional states has been a longstanding challenge in structural biology. While integrative structural biology has been the most effective way to get a high-accuracy structure of ...
Davide Sala +4 more
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Nonenzymatic RNA-templated Synthesis of N3′→P5′ Phosphoramidate DNA
Bio-Protocol, 2020 The RNA world hypothesis describes a scenario where early life forms relied on RNA to govern both inheritance and catalyze useful chemical reactions.
Derek O'Flaherty +2 more
doaj +1 more source
Scientific Reports, 2022 Rapid, cost-effective identification of genetic variants in small candidate genomic regions remains a challenge, particularly for less well equipped or lower throughput laboratories.
Whitney Whitford +6 more
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Oncogene inference optimization using constraint-based modelling incorporated with protein expression in normal and tumour tissues [PDF]
Royal Society Open Science, 2020 Cancer cells are known to exhibit unusual metabolic activity, and yet few metabolic cancer driver genes are known. Genetic alterations and epigenetic modifications of cancer cells result in the abnormal regulation of cellular metabolic pathways that are ...
Wu-Hsiung Wu +6 more
doaj +1 more source
Guided Genetic Algorithm: A New Template Concept
Procedia Computer Science, 2015 AbstractGuided genetic algorithm and dynamic distributed double guided genetic algorithm are based on nature laws and by the Neo-Darwinism theory. These evolutionary approaches were very successful addressing Maximal Constraint Satisfaction Problems (Max-CSPs). Our work is inspired by a little mistake when dealing with in these two algorithms guidance.
Hajer Ben Othman, Moncef Tagina
openaire +1 more source
An analysis of heuristic templates in Genetic Programming for one-dimensional cutting and packing problems [PDF]
Proceedings of the Companion Conference on Genetic and Evolutionary Computation, 2023 One-dimensional cutting stock and packing problems require determining a set of patterns that are applied a number of times each on raw material pieces to produce a number of customer orders. Among many other solving methods, greedy algorithms guided by heuristic rules stand out due to their low computational cost and ability to be adapted to sets of ...
Jesús Quesada +4 more
openaire +2 more sources
Transformation and CRISPR-Cas9-mediated homologous recombination in the fungus Rhizopus microsporus
STAR Protocols, 2022 Summary: Here, we describe a reliable approach for targeted DNA integrations in the genome of R. microsporus, one of the main causal agents of mucormycosis.
Carlos Lax +5 more
doaj +1 more source
Random-PE: an efficient integration of random sequences into mammalian genome by prime editing
Molecular Biomedicine, 2021 Prime editing (PE) enables efficiently targeted introduction of multiple types of small-sized genetic change without requiring double-strand breaks or donor templates.
Yaoge Jiao +7 more
doaj +1 more source
Binary Genetic Cassettes for Selecting XNA‐Templated DNA Synthesis In Vivo [PDF]
Angewandte Chemie, 2013 sponsorship: GOA 10/013 IDO FWO Vlaanderen Genoscope (Genopole, Evry)(ATIGE, EA 4527, UPS 3509) FP7/2007-2013)/ERC Grant agreement n° ERC-2012- ADG_20120216/320683.XNA - xenobiotic nucleic acids.
Pezo, Valérie +5 more
openaire +4 more sources