Co-design, implementation, and evaluation of plain language genomic test reports
npj Genomic Medicine, 2022 Understanding and communicating genomic results can be challenging for families and health professionals without genetic specialty training. Unlike modifying existing laboratory reports, plain language genomic test reports provide an opportunity for ...
Gemma R. Brett +8 more
doaj +1 more source
Template-directed synthesis of a genetic polymer in a model protocell [PDF]
Nature, 2008 Contemporary phospholipid-based cell membranes are formidable barriers to the uptake of polar and charged molecules ranging from metal ions to complex nutrients. Modern cells therefore require sophisticated protein channels and pumps to mediate the exchange of molecules with their environment.
Mansy, Sheref Samir +5 more
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Extensive recombination due to heteroduplexes generates large amounts of artificial gene fragments during PCR. [PDF]
PLoS ONE, 2014 Artificial recombinants can be generated during PCR when more than two genetically distinct templates coexist in a single PCR reaction. These recombinant amplicons can lead to the false interpretation of genetic diversity and incorrect identification of ...
Jia Liu +6 more
doaj +1 more source
View-Invariant Gait Recognition Through Genetic Template Segmentation [PDF]
IEEE Signal Processing Letters, 2017 Template-based model-free approach provides by far the most successful solution to the gait recognition problem in literature. Recent work discusses how isolating the head and leg portion of the template increase the performance of a gait recognition system making it robust against covariates like clothing and carrying conditions. However, most involve
Ebenezer R. H. P. Isaac +3 more
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An unbiased template of the Drosophila brain and ventral nerve cord.
PLoS ONE, 2020 The fruit fly Drosophila melanogaster is an important model organism for neuroscience with a wide array of genetic tools that enable the mapping of individual neurons and neural subtypes.
John A Bogovic +10 more
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Preferential access to genetic information from endogenous hominin ancient DNA and accurate quantitative SNP-typing via SPEX [PDF]
, 2009 The analysis of targeted genetic loci from ancient, forensic and clinical samples is usually built upon polymerase chain reaction (PCR)-generated sequence data.
Endicott, Phillip +8 more
core +1 more source
Frontiers in Molecular Biosciences, 2023 Determining the three-dimensional structure of proteins in their native functional states has been a longstanding challenge in structural biology. While integrative structural biology has been the most effective way to get a high-accuracy structure of ...
Davide Sala +4 more
doaj +1 more source
Novel high-resolution characterization of ancient DNA reveals C > U-type base modification events as the sole cause of post mortem miscoding lesions [PDF]
, 2007 Ancient DNA (aDNA) research has long depended on the power of PCR to amplify trace amounts of surviving genetic material from preserved specimens. While PCR permits specific loci to be targeted and amplified, in many ways it can be intrinsically unsuited
Endicott, Phillip +28 more
core +1 more source
Nonenzymatic RNA-templated Synthesis of N3′→P5′ Phosphoramidate DNA
Bio-Protocol, 2020 The RNA world hypothesis describes a scenario where early life forms relied on RNA to govern both inheritance and catalyze useful chemical reactions.
Derek O'Flaherty +2 more
doaj +1 more source
Guided Genetic Algorithm: A New Template Concept
Procedia Computer Science, 2015 AbstractGuided genetic algorithm and dynamic distributed double guided genetic algorithm are based on nature laws and by the Neo-Darwinism theory. These evolutionary approaches were very successful addressing Maximal Constraint Satisfaction Problems (Max-CSPs). Our work is inspired by a little mistake when dealing with in these two algorithms guidance.
Hajer Ben Othman, Moncef Tagina
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