Results 21 to 30 of about 3,144,500 (368)

An unbiased template of the Drosophila brain and ventral nerve cord.

PLoS ONE, 2020
The fruit fly Drosophila melanogaster is an important model organism for neuroscience with a wide array of genetic tools that enable the mapping of individual neurons and neural subtypes.
John A Bogovic, Hideo Otsuna, Larissa Heinrich, Masayoshi Ito, Jennifer Jeter, Geoffrey Meissner, Aljoscha Nern, Jennifer Colonell, Oz Malkesman, Kei Ito, Stephan Saalfeld   +10 more
doaj   +1 more source

Recommendations for designing genetic test reports to be understood by patients and non-specialists

European Journal of Human Genetics, 2020
Patients and non-specialist healthcare professionals are increasingly expected to understand and interpret the results of genetic or genomic testing. These results are currently reported using a variety of templates, containing different amounts, levels,
George D. Farmer, Harry Gray, G. Chandratillake, F. Raymond, A. Freeman   +4 more
semanticscholar   +1 more source

Proof of concept for multiplex amplicon sequencing for mutation identification using the MinION nanopore sequencer

Scientific Reports, 2022
Rapid, cost-effective identification of genetic variants in small candidate genomic regions remains a challenge, particularly for less well equipped or lower throughput laboratories.
Whitney Whitford, Victoria Hawkins, Kriebashne S. Moodley, Matthew J. Grant, Klaus Lehnert, Russell G. Snell, Jessie C. Jacobsen   +6 more
doaj   +1 more source

Binary Genetic Cassettes for Selecting XNA‐Templated DNA Synthesis In Vivo [PDF]

Angewandte Chemie, 2013
ispartof: location ...
Pezo, Valérie, Liu, Feng Wu, Abramov, Mikhail, Froeyen, Mathy, Herdewijn, Piet, Marlière, Philippe   +5 more
openaire   +6 more sources

Oncogene inference optimization using constraint-based modelling incorporated with protein expression in normal and tumour tissues [PDF]

Royal Society Open Science, 2020
Cancer cells are known to exhibit unusual metabolic activity, and yet few metabolic cancer driver genes are known. Genetic alterations and epigenetic modifications of cancer cells result in the abnormal regulation of cellular metabolic pathways that are ...
Wu-Hsiung Wu, Fan-Yu Li, Yi-Chen Shu, Jin-Mei Lai, Peter Mu-Hsin Chang, Chi-Ying F. Huang, Feng-Sheng Wang   +6 more
doaj   +1 more source

Nonenzymatic RNA-templated Synthesis of N3′→P5′ Phosphoramidate DNA

Bio-Protocol, 2020
The RNA world hypothesis describes a scenario where early life forms relied on RNA to govern both inheritance and catalyze useful chemical reactions.
Derek O'Flaherty, Lijun Zhou, Jack Szostak   +2 more
doaj   +1 more source

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Andrew Tuplin, Bartenschlager, Blight, Blight, Brown, Bukh, Cheng, David J. Evans, Davis, Diviney, Friebe, Friebe, Friebe, Gamarnik, Gesteland, Giegé, Ikeda, Ito, Ito, Jubin, Klinck, Kuiken, Lee, Lindenbach, Liu, Lohmann, Lohmann, Lohmann, Madeleine Struthers, Markham, Matsuda, Matsuda, McMullan, Murayama, Pang, Peter Simmonds, Pietschmann, Romero-López, Romero-López, Schmitt, Simmonds, Song, Tuplin, Tuplin, Tuplin, Wakita, Wang, Wang, Wasley, Wilkinson, Yang, Yi, You, You, Zhao, Zhong, Zuker   +56 more
core   +3 more sources

Random-PE: an efficient integration of random sequences into mammalian genome by prime editing

Molecular Biomedicine, 2021
Prime editing (PE) enables efficiently targeted introduction of multiple types of small-sized genetic change without requiring double-strand breaks or donor templates.
Yaoge Jiao, Lifang Zhou, Rui Tao, Yanhong Wang, Yun Hu, Lurong Jiang, Li Li, Shaohua Yao   +7 more
doaj   +1 more source

The origins and physical roots of life’s dual – metabolic and genetic – nature [PDF]

, 2017
This review paper aims at a better understanding of the origin and physical foundation of life’s dual – metabolic and genetic – nature. First, I give a concise ‘top-down’ survey of the origin of life, i.e., backwards in time from extant DNA/RNA/protein ...
De Tiège, Alexis
core   +2 more sources

Guided Genetic Algorithm: A New Template Concept

Procedia Computer Science, 2015
AbstractGuided genetic algorithm and dynamic distributed double guided genetic algorithm are based on nature laws and by the Neo-Darwinism theory. These evolutionary approaches were very successful addressing Maximal Constraint Satisfaction Problems (Max-CSPs). Our work is inspired by a little mistake when dealing with in these two algorithms guidance.
Moncef Tagina, Hajer Ben Othman
openaire   +2 more sources