Results 31 to 40 of about 219,031 (288)
Avoiding chromosome pathology when replication forks collide [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG +3 more
core +1 more source
Use of genetic markers for the detection of off-types for DUS phenotypic traits in the inbreeding crop, barley [PDF]
, 2020 Detection of crop off-types is of interest for multiple uses, including the assessment of uniformity for new plant variety applications during distinctness, uniformity and stability (DUS) testing for the awarding of plant breeders’ rights (PBR). Here,
Cockram, James +4 more
core +1 more source
Assessing DNA Sequence Alignment Methods for Characterizing Ancient Genomes and Methylomes
Frontiers in Ecology and Evolution, 2020 Applying high-throughput DNA sequencing technologies to the ancient DNA molecules preserved in subfossil material can provide genetic information from past individuals, populations, and communities at the genomic scale.
Marine Poullet +2 more
doaj +1 more source
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]
, 2016 Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien +12 more
core +2 more sources
Probing Ambiguous Base‐Pairs by Genetic Transformation with XNA Templates
ChemBioChem, 2014 AbstractThe templating potential of anhydrohexitol oligonucleotides bearing ambiguous bases was studied in vivo, by using a selection screen for mosaic heteroduplex plasmids in Escherichia coli. 1,5‐Anhydro‐2,3‐dideoxy‐2‐(5‐nitroindazol‐1‐yl)‐D‐arabino‐hexitol showed the greatest ambiguity among the three nucleosides tested.
Pezo, Valérie +4 more
openaire +3 more sources
Journal of Nucleic Acids, 2012 For the site-specific labeling and modification of RNA by genetic alphabet expansion, we developed a PCR and transcription system using two hydrophobic unnatural base pairs: 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) and 2-nitro-4-propynylpyrrole (Px) as ...
Michiko Kimoto +3 more
doaj +1 more source
Food Technology and Biotechnology, 2016 We have constructed two plasmids that can be used for cloning as templates for PCR-based gene disruption, mutagenesis and the construction of DNA chromosome translocation cassettes.
Remigiusz Arnak +3 more
doaj +1 more source
Jurnal Biodjati, 2023 Cogongrass is one of the top ten problem-causing weeds in the world that is invasively spread over many tropical and subtropical regions, including Java Island, the Republic of Indonesia. The wide distribution is possibly related to their adaptability to
Murni Dwiati +2 more
doaj +1 more source
PrimPol is required for replicative tolerance of G quadruplexes in vertebrate cells [PDF]
, 2016 G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epigenetic instability.
Bailey, Laura J +7 more
core +1 more source
G3: Genes, Genomes, Genetics, 2019 DNA double-strand breaks (DSBs) are especially toxic DNA lesions that, if left unrepaired, can lead to wide-ranging genomic instability. Of the pathways available to repair DSBs, the most accurate is homologous recombination (HR), where a homologous ...
Joel Fernandez +3 more
doaj +1 more source