Results 41 to 50 of about 508,564 (288)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Working methodologically on system innovations [PDF]
, 2011 Dutch agriculture is facing the challenge to develop into a sustainable sector. To achieve this goal, innovations are needed which force breaks with past trends and speed up the tempo of sustainable development. The System Innovation Programmes developed
Vogelezang, J.V.M., Wijnands, F.G.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Communicative participation improves following motor speech program treatment in apraxia of speech [PDF]
, 2018 Childhood apraxia of speech (CAS) is a motor speech disorder characterized by increase in segment and intersegment durations (segmentation), equal stress over words and/or sentences, dysprosody, and speech sound distortions.
Schultz, Emily A
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Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Efeito do sistema de manejo sob o comportamento em pastejo de cabras leiteiras. [PDF]
, 2019 O experimento foi conduzido na Embrapa Caprinos para avaliar o efeito do pastejo restrito (8 às 16 horas)e do pastejo em período integral sobre o comportamento em pastejo de caprinos leiteiros. Foram utilizadas cabras das raças Saanen e Anglo-nubiana. As
BARBOSA, G. N. F. +3 more
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Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
O educar na educação de tempo integral: Desafios para a iniciação a docência [PDF]
, 2014 Anais do II Seminário Seminário Estadual PIBID do Paraná: tecendo saberes / organizado por Dulcyene Maria Ribeiro e Catarina Costa Fernandes — Foz do Iguaçu: Unioeste; Unila, 2014Vivencia-se um momento no qual o distanciamento da construção e aquisição ...
Franke, Queli Jovilda Marques +3 more
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O tempo e sua essencialidade na escola de tempo integral
Revista Educação em Questão, 2020 Este estudo, vinculado ao Grupo de Pesquisa “Políticas, Gestão e Financiamento em Educação” – Pogefe, analisa o tempo como construção social e histórica no processo civilizador, seu papel na rotina humana e sua essencialidade para a escola de tempo integral.
Tereza Guimarães, Elisangela Bernado
openaire +2 more sources
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source