Results 21 to 30 of about 19,761,197 (221)
Tenascin-C and integrins in cancer [PDF]
Cell Adhesion & Migration, 2015 Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of ...
Yoshida, Toshimichi +2 more
openaire +2 more sources
The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis
Medicine Science, 2021 Acute pancreatitis (AP) constitutes an activation of a variety of enzymes secreted by the pancreas and is a continuing inflammatory process where the pancreas damages itself.
Adil Ugur Cetin +4 more
doaj +1 more source
The Role of Tenascin-C in Neuroinflammation and Neuroplasticity. [PDF]
Int J Mol SciTenascin-C (TNC) is a complex extracellular matrix (ECM) protein that plays a critical role in regulating cellular adhesion, motility, proliferation, and inflammation through its interaction with Toll-like receptor 4 (TLR4) and other receptors. The upregulation of TNC is associated with inflammatory responses, autoimmune disorders, and neoplastic ...
Jin YL +5 more
europepmc +3 more sources
Tenascin-C: as a diagnostic biomarker for rheumatic heart disease
Egyptian Pediatric Association Gazette, 2023 Background Rheumatic fever is a long-term inflammatory disease that can happen if group A beta-hemolytic streptococci bacteria are not treated well enough.
Maha M. A. Abo-Hashish +5 more
doaj +1 more source
Tenascin-C: a marker and driver of inflammation [PDF]
, 2020 Tenascin-C, the founding member of the matricellular tenascin family, is a large multifunctional hexameric extracellular matrix (ECM) glycoprotein. It is abundantly expressed in the developing embryo but its expression becomes tightly regulated in the ...
Ozanne, James Henry John
core +1 more source
Tenascin-C is a driver of inflammation in the DSS model of colitis
Matrix Biology Plus, 2022 Inflammatory Bowel Disease (IBD) is a grouping of chronic inflammatory disorders of the gut. Tenascin-C is a pro-inflammatory, extracellular matrix protein found upregulated in IBD patients and whilst a pathological driver of chronic inflammation, its ...
James Ozanne +7 more
doaj +1 more source
Tenascin-C in Osteoarthritis and Rheumatoid Arthritis [PDF]
Frontiers in Immunology, 2020 Tenascin-C (TNC) is a large multimodular glycoprotein of the extracellular matrix that consists of four distinct domains. Emerging evidence suggests that TNC may be involved in the pathogenesis of osteoarthritis (OA) and rheumatoid arthritis (RA). In this review, we summarize the current understanding of the role of TNC in cartilage and in synovial ...
Masahiro Hasegawa +2 more
openaire +3 more sources
The last tenascin : insights on tenascin-W functions and regulation [PDF]
, 2012 Over the last decade, it became clear that the tumor stroma plays an active role in the process of tumor progression, by interacting with the transformed cells and providing a permissive microenvironment for malignant growth.
Martina, Enrico
core +1 more source
Characterization of tenascin-C-induced signaling in tumorigenesis [PDF]
, 2008 During cancer progression, the extracellular matrix (ECM) is extensively remodeled. The ECM molecule tenascin-C is an adhesion-modulating molecule, which is highly expressed in tumor stroma.
Lange, Katrin
core +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source