Results 51 to 60 of about 1,312,393 (235)

Hybrid Continuum Robot Designs and Architectures for Healthcare Applications

Advanced Robotics Research, EarlyView.
Hybrid continuum robots represent an emerging class of flexible manipulators that blend materials, structures, and actuation concepts from the established fields of soft and continuum robotics. This review introduces an accessible framework to distinguish key hybridization approaches, surveys current designs aimed at complex clinical applications, and ...
Burak Ozdemir, Muhammad A. Khalid, Manish Chauhan, Pietro Valdastri, James H. Chandler   +4 more
wiley   +1 more source

Mechanical Loading Improves Tendon-Bone Healing in a Rabbit Anterior Cruciate Ligament Reconstruction Model by Promoting Proliferation and Matrix Formation of Mesenchymal Stem Cells and Tendon Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: This study investigated the effect of mechanical stress on tendon-bone healing in a rabbit anterior cruciate ligament (ACL) reconstruction model as well as cell proliferation and matrix formation in co-culture of bone-marrow mesenchymal ...
Fanglong Song, Dawei Jiang, Tianchen Wang, Yi Wang, Fengmei Chen, Guoxing Xu, Yifan Kang, Yinquan Zhang   +7 more
doaj   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Current Issues and Regulations in Tendon Regeneration and Musculoskeletal Repair with Mesenchymal Stem Cells

, 2011
Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described.
Grange, Simon
core   +1 more source

The Roles of MicroRNAs in Tendon Healing and Regeneration

Frontiers in Cell and Developmental Biology, 2021
Tendons connect the muscle abdomen of skeletal muscles to the bone, which transmits the force generated by the muscle abdomen contraction and pulls the bone into motion.
Lingli Ding, Min Wang, Shengnan Qin, Liangliang Xu   +3 more
doaj   +1 more source

Torsional stability of interference screws derived from bovine bone - a biomechanical study [PDF]

, 2010
Introduction: It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an ...
Zayat, Bilal Farouk el, Markus Dietmar Schofer, Silke Herdrich, Bauer, Joscha, Timmesfeld, Nina, Joscha Bauer, Bilal Farouk El-Zayat, Schofer, Markus Dietmar, Schmitt, Jan, Leo Gotzen, Turgay Efe, Jan Schmitt, Gotzen, Leo, Nina Timmesfeld, Efe, Turgay, Herdrich, Silke   +15 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Effect of difference in fixation methods of tendon graft and the microfracture procedure on tendon-bone junction healing

JSES International, 2022
Background: There are generally two methods of fixation for tendon grafts used in ligament reconstruction: bone tunnel fixation and anchor fixation. The microfracture (Mf) procedure is a technique to induce bleeding from the bone marrow, and the bleeding
Satoshi Nezu, MD, Taichi Saito, MD, PhD, Aki Yoshida, PhD, Shinji Narazaki, MD, PhD, Yasunori Shimamura, MD, PhD, Takayuki Furumatsu, MD, PhD, Toshifumi Ozaki, MD, PhD   +6 more
doaj   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Endothelialized tissue engineered 3D-construct for bone repair [PDF]

, 2005
One of the main problems arising when implanting a graft into a large bone gap is its insufficient vascularization in the central region. This results in impaired bone healing and often leads to necrosis in the graft.
Meury, Thomas
core   +1 more source