Results 31 to 40 of about 33,351 (233)

Tendon Reattachment to Bone in an Ovine Tendon Defect Model of Retraction Using Allogenic and Xenogenic Demineralised Bone Matrix Incorporated with Mesenchymal Stem Cells. [PDF]

PLoS ONE, 2016
BACKGROUND:Tendon-bone healing following rotator cuff repairs is mainly impaired by poor tissue quality. Demineralised bone matrix promotes healing of the tendon-bone interface but its role in the treatment of tendon tears with retraction has not been ...
Tanujan Thangarajah, Shirin Shahbazi, Catherine J Pendegrass, Simon Lambert, Susan Alexander, Gordon W Blunn   +5 more
doaj   +1 more source

Activation of CGRP receptor-mediated signaling promotes tendon-bone healing. [PDF]

Sci Adv
Calcitonin gene-related peptide (CGRP), an osteopromotive neurotransmitter with a short half-life, shows increase while calcitonin receptor-like (CALCRL) level is decreased at the early stage in bone fractures. Therefore, the activation of CALCRL-mediated signaling may be more critical to promote the tendon-bone healing.
Zhao X, Wu G, Zhang J, Yu Z, Wang J.
europepmc   +3 more sources

Effect of secretory leucocyte protease inhibitor on early tendon-to-bone healing after anterior cruciate ligament reconstruction in a rat model

Bone & Joint Research, 2022
Aims: To verify whether secretory leucocyte protease inhibitor (SLPI) can promote early tendon-to-bone healing after anterior cruciate ligament (ACL) reconstruction. Methods: In vitro: the mobility of the rat bone mesenchymal stem cells (BMSCs) treated
Yongmao Wu, Yan Shao, Denghui Xie, Jianying Pan, Huabin Chen, Juncheng Yao, Jiarong Liang, Haolin Ke, Daozhang Cai, Chun Zeng   +9 more
doaj   +1 more source

Bone Tendon Interface: A New Perspective on Rotator Cuff Healing

Orthopaedic Journal of Sports Medicine, 2019
During rotator cuff repair surgery, fixation and incorporation of ruptured rotator cuff tendon into the bone is a major concern. Many studies have report the limitations in the healing potential of the bone-tendon interface. The structure and composition
Yucheng Sun MD, PhD, Erica Kholinne MD, PhD, PhD, In-Ho Jeon MD, PhD   +2 more
doaj   +1 more source

Differences in placement of calcium phosphate-hybridized tendon grafts within the femoral bone tunnel during ACL reconstruction do not influence tendon-to-bone healing

Journal of Orthopaedic Surgery and Research, 2017
Background Calcium phosphate (CaP)-hybridization of tendon grafts has been shown to improve tendon-to-bone healing. The purpose of this study was to clarify the influence of different tendon graft placement methods on tendon-to-bone healing using CaP ...
Hirotaka Mutsuzaki, Hiromi Nakajima, Shunsuke Nomura, Masataka Sakane   +3 more
doaj   +1 more source

Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway

Materials Today Bio, 2022
Graft healing after anterior cruciate ligament reconstruction (ACLR) involves slow biological processes, and various types of biological modulations have been explored to promote tendon-to-bone integration.
Xiang-Dong Wu, Lin Kang, Jingjing Tian, Yuanhao Wu, Yue Huang, Jieying Liu, Hai Wang, Guixing Qiu, Zhihong Wu   +8 more
doaj   +1 more source

Demineralized Bone Matrix to Augment Tendon-Bone Healing: A Systematic Review [PDF]

Orthopaedic Journal of Sports Medicine, 2017
Background: Following injury to the rotator cuff and anterior cruciate ligament, a direct enthesis is not regenerated, and healing occurs with biomechanically inferior fibrous tissue. Demineralized bone matrix (DBM) is a collagen scaffold that contains growth factors and is a promising biological material for ...
Hexter, AT, Pendegrass, C, Haddad, F, Blunn, G   +3 more
openaire   +4 more sources

Macrophage-Derived miRNA-Containing Exosomes Induce Peritendinous Fibrosis after Tendon Injury through the miR-21-5p/Smad7 Pathway

Molecular Therapy: Nucleic Acids, 2019
Following tendon injury, the development of fibrotic healing response impairs tendon function and restricts tendon motion. Peritendinous tissue fibrosis poses a major clinical problem in hand surgery.
Haomin Cui, Yu He, Shuai Chen, Deming Zhang, Yaling Yu, Cunyi Fan   +5 more
doaj   +1 more source

Negative effect of zoledronic acid on tendon-to-bone healing: In vivo study of biomechanics and bone remodeling in a rat model

Acta Orthopaedica, 2018
Background and purpose — Outcome after ligament reconstruction or tendon repair depends on secure tendon-to-bone healing. Increased osteoclastic activity resulting in local bone loss may contribute to delayed healing of the tendon–bone interface.
Geir Aasmund Hjorthaug, Endre Søreide, Lars Nordsletten, Jan Erik Madsen, Finn P Reinholt, Sanyalak Niratisairak, Sigbjørn Dimmen   +6 more
doaj   +1 more source

Comparison of bone surface and trough fixation on bone–tendon healing in a rabbit patella–patellar tendon injury model

Journal of Orthopaedic Translation, 2020
Background: Many orthopedic surgical procedures involve reattachment between tendon and bone. Whether bone–tendon healing is better facilitated by tendon fixation on a bone surface or within a tunnel is unknown.
Muzhi Li, Yifu Tang, Can Chen, Jiefu Zhou, Cheng Zheng, Huabin Chen, Hongbin Lu, Jin Qu   +7 more
doaj   +1 more source