Application and optimization of bioengineering strategies in facilitating tendon–bone healing [PDF]
BioMedical Engineering OnLineTendon–bone insertion trauma is prevalent in both rotator cuff and anterior cruciate ligament injuries, which are frequently encountered conditions in the field of sports medicine. The main treatment for such injuries is reconstructive surgery.
Chenhui Yang +6 more
doaj +4 more sources
Mesenchymal stem cells and macrophages and their interactions in tendon-bone healing
Journal of Orthopaedic Translation, 2023 Tendon-bone insertion injuries (TBI), such as anterior cruciate ligament (ACL) and rotator cuff injuries, are common degenerative or traumatic pathologies with a negative impact on the patient's daily life, and they cause huge economic losses every year.
Zhuo Chen +8 more
doaj +3 more sources
Engineered exosomes: A promising strategy for tendon-bone healing [PDF]
Journal of Advanced ResearchDue to the spatiotemporal complexity of the composition, structure, and cell population of the tendon-bone interface (TBI), it is difficult to achieve true healing. Recent research is increasingly focusing on engineered exosomes, which are a promising strategy for TBI regeneration.This review discusses the physiological and pathological characteristics
Shijie Fu, Bo Qin, Dingsu Bao
exaly +4 more sources
Advances focusing on the application of decellularization methods in tendon-bone healing [PDF]
Journal of Advanced ResearchThe tendon or ligament is attached to the bone by a triphasic but continuous area of heterogeneous tissue called the tendon-bone interface (TBI). The rapid and functional regeneration of TBI is challenging owing to its complex composition and difficulty in self-healing.
Sheng Zhong, Zhipeng Hou, Shijie Fu
exaly +5 more sources
A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in vivo [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Background: Tendon-bone healing is an important factor in determining the success of ligament reconstruction. With the development of biomaterials science, the tissue engineering scaffold plays an extremely important role in tendon-bone healing and bone ...
Zimu Mao +23 more
doaj +3 more sources
Bioengineered periosteal progenitor cell sheets to enhance tendon-bone healing in a bone tunnel
Biomedical Journal, 2012 Background: Tendon-bone tunnel healing is crucial for long term success in anterior cruciate ligament (ACL) reconstruction. The periosteum contains osteochondral progenitor cells that can differentiate into osteoblasts and chondroblasts during tendon ...
Chih-Hsiang Chang +6 more
doaj +3 more sources
Comparative effects of cyclooxygenase-2 selective and nonselective nonsteroidal anti-inflammatory drugs and acetaminophen on rotator cuff tendon–bone healing in a rat model [PDF]
Acta Orthopaedica et Traumatologica TurcicaObjective: This study aimed to investigate and compare the effects of naproxen (a nonselective nonsteroidal anti-inflammatory drug [NSAID]), celecoxib (a cyclooxygenase (COX)-2 selective NSAID), and acetaminophen (an analgesic with minimal anti ...
Ebubekir Bektaş +3 more
doaj +2 more sources
Stem cell-derived exosomes: a potential therapeutic strategy for enhancing tendon stem/progenitor cells function in tendon-bone healing [PDF]
Journal of Orthopaedic Surgery and ResearchTendon-bone insertion (TBI) injuries and diseases are one of the common musculoskeletal conditions that can severely impair an individual’s daily activities and quality of life.
Junjie Tang +4 more
doaj +2 more sources
Comparative effect of skeletal stem cells versus bone marrow mesenchymal stem cells on rotator cuff tendon-bone healing [PDF]
Journal of Orthopaedic TranslationBackground: Bone marrow mesenchymal stem cells (BMSCs) have immense potential in applications for the enhancement of tendon-bone (T-B) healing.
Linfeng Wang +7 more
doaj +2 more sources
A New Tissue Engineering Strategy to Promote Tendon–bone Healing: Regulation of Osteogenic and Chondrogenic Differentiation of Tendon‐derived Stem Cells [PDF]
Orthopaedic SurgeryIn the field of sports medicine, repair surgery for anterior cruciate ligament (ACL) and rotator cuff (RC) injuries are remarkably common. Despite the availability of relatively effective treatment modalities, outcomes often fall short of expectations ...
Sinuo Shen +5 more
doaj +2 more sources