Results 31 to 40 of about 21,653 (110)

Boost Tendon/Ligament Repair With Biomimetic and Smart Cellular Constructs

Frontiers in Bioengineering and Biotechnology, 2021
Tendon and ligament are soft connective tissues that play essential roles in transmitting forces from muscle to bone or bone to bone. Despite significant progress made in the field of ligament and tendon regeneration over the past decades, many ...
Jianping Zhao, Jianping Zhao, Xiang Wang, Jinyu Han, Yin Yu, Fei Chen, Jun Yao   +6 more
doaj   +1 more source

Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats

Stem Cell Research & Therapy
Background The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promote the regeneration of a ...
Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger   +9 more
doaj   +1 more source

Establishment of a human pluripotent stem cell-derived MKX-td Tomato reporter system

Stem Cell Research & Therapy, 2022
Tendon regeneration is difficult because detailed knowledge about tendon progenitor cells (TPCs), which produce tenocytes to repair tendon tissue, has not been revealed. Mohawk homeobox (MKX) is a marker of TPCs or tenocytes, but a human pluripotent stem
Yuki Fujisawa, Lu Ming, Daisuke Yamada, Tomoka Takao, Takeshi Takarada   +4 more
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Serum MicroRNA signatures associated with hypertrophic callus formation in polytrauma patients with traumatic brain injury

Scientific Reports
Long-bone fractures occasionally develop excessive callus formation in the presence of traumatic brain injury, a clinically relevant but poorly understood injury response.
Thomas Lettner, Florian Dussing, Renate Gehwolf, Christian Deininger, Amelie Deluca, Verena Wally, Valeska Hofmann, Matthias Hackl, Andreas Traweger, Florian Wichlas   +9 more
doaj   +1 more source

Tendon mechanobiology in the context of tendon biofabrication

Frontiers in Bioengineering and Biotechnology
Tendons are often affected by injuries or tendinopathies, resulting in serious and long-lasting impairments. The repair capacity is very low with a high risk of rerupture.
Clemens Gögele, Girish Pattappa, Herbert Tempfer, Herbert Tempfer, Denitsa Docheva, Gundula Schulze-Tanzil   +5 more
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Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models

Bioengineering & Translational Medicine, 2023
Chronic rotator cuff tears (RCTs) are one of the most common injuries of shoulder pain. Despite the recent advances in surgical techniques and improved clinical outcomes of arthroscopically repaired rotator cuffs (RCs), complete functional recovery ...
Yonghyun Gwon, Woochan Kim, Sunho Park, Yang‐Kyung Kim, Hyoseong Kim, Myung‐Sun Kim, Jangho Kim   +6 more
doaj   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science
Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration. Although tendon stem/progenitor cells (TSPCs) are pivotal for tendon engineering, achieving microstructure and functional ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
doaj   +1 more source

Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon

npj Regenerative Medicine, 2023
Tendons are essential, frequently injured connective tissues that transmit forces from muscle to bone. Their unique highly ordered, matrix-rich structure is critical for proper function. While adult mammalian tendons heal after acute injuries, endogenous
Stephanie L. Tsai, Steffany Villaseñor, Rishita R. Shah, Jenna L. Galloway   +3 more
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Engineering an extracellular matrix-functionalized, load-bearing tendon substitute for effective repair of large-to-massive tendon defects

Bioactive Materials
A significant clinical challenge in large-to-massive rotator cuff tendon injuries is the need for sustaining high mechanical demands despite limited tissue regeneration, which often results in clinical repair failure with high retear rates and long-term ...
Shuting Huang, Ying Rao, Meng Zhou, Anna M. Blocki, Xiao Chen, Chunyi Wen, Dai Fei Elmer Ker, Rocky S. Tuan, Dan Michelle Wang   +8 more
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A Regenerated Achilles Tendon with Good Function One Year After Total Extirpation Due to Infection – A Case Report

International Medical Case Reports Journal, 2022
Martin Granath,1 Pär Hedlund,1 Christoph Spang,2 Håkan Alfredson3,4 1Orthopaedic Department, Hässleholm Hospital, Hässleholm, Sweden; 2Private Orthopaedic Spine Center, Würzburg, Germany; 3Institute of Sports Exercise and Health, University College ...
Granath M, Hedlund P, Spang C, Alfredson H   +3 more
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