Results 31 to 40 of about 458,172 (134)

MicroRNA engineered umbilical cord stem cell-derived exosomes direct tendon regeneration by mTOR signaling

Journal of Nanobiotechnology, 2021
Background Exosomes are extracellular vesicles of nano-structures and represent an emerging nano-scale acellular therapy in recent years. Tendon regeneration is a sophisticated process in the field of microsurgery due to its poor natural healing ability.
Zhixiao Yao, Juehong Li, Hao Xiong, Haomin Cui, Jiexin Ning, Shikun Wang, Xingyu Ouyang, Yun Qian, Cunyi Fan   +8 more
doaj   +1 more source

Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity

Advanced Science
Tendinopathy is a long‐lasting, debilitating disease that not only affects patients' individual lives, but also imposes a significant socioeconomic burden.
Renate Gehwolf, Herbert Tempfer, Nevra Pelin Cesur, Andrea Wagner, Andreas Traweger, Christine Lehner   +5 more
doaj   +1 more source

Biology and augmentation of tendon-bone insertion repair

Journal of Orthopaedic Surgery and Research, 2010
Surgical reattachment of tendon and bone such as in rotator cuff repair, patellar-patella tendon repair and anterior cruciate ligament (ACL) reconstruction often fails due to the failure of regeneration of the specialized tissue ("enthesis") which ...
Lui PPY, Zhang P, Chan KM, Qin L
doaj   +1 more source

Boost Tendon/Ligament Repair With Biomimetic and Smart Cellular Constructs

Frontiers in Bioengineering and Biotechnology, 2021
Tendon and ligament are soft connective tissues that play essential roles in transmitting forces from muscle to bone or bone to bone. Despite significant progress made in the field of ligament and tendon regeneration over the past decades, many ...
Jianping Zhao, Jianping Zhao, Xiang Wang, Jinyu Han, Yin Yu, Fei Chen, Jun Yao   +6 more
doaj   +1 more source

Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats

Stem Cell Research & Therapy
Background The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promote the regeneration of a ...
Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger   +9 more
doaj   +1 more source

Enhanced Effect of Tendon Stem/Progenitor Cells Combined With Tendon-Derived Decellularized Extracellular Matrix on Tendon Regeneration

Cell Transplantation, 2018
Decellularized extracellular matrices have been clinically used for tendon regeneration. However, only a few systematic studies have compared tendon stem/progenitor cells to mesenchymal stromal cells on the tendon-derived decellularized matrix.
Haixin Song, Zi Yin, Tao Wu, Yangzheng Li, Xun Luo, Mingzhu Xu, Lihong Duan, Jianhua Li   +7 more
doaj   +1 more source

Establishment of a human pluripotent stem cell-derived MKX-td Tomato reporter system

Stem Cell Research & Therapy, 2022
Tendon regeneration is difficult because detailed knowledge about tendon progenitor cells (TPCs), which produce tenocytes to repair tendon tissue, has not been revealed. Mohawk homeobox (MKX) is a marker of TPCs or tenocytes, but a human pluripotent stem
Yuki Fujisawa, Lu Ming, Daisuke Yamada, Tomoka Takao, Takeshi Takarada   +4 more
doaj   +1 more source

Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation [PDF]

, 2011
The ability of tendons to glide smoothly during muscle contraction is impaired after injury by fibrous adhesions that form between the damaged tendon surface and surrounding tissues. To understand how adhesions form we incubated excised tendons in fibrin
Al-Youha Sarah, Susan H Taylor, Van Agtmael Tom, Van Agtmael, T., Wong, J., Lu Yinhui, Wong Jason, Kadler Karl E., Duncan A. McGrouther, Jason Wong, Taylor, Susan H, Kadler, Karl E; id_orcid, Al-Youha, Sarah, McGrouther, Duncan A, Agarwal, S., Duncan A McGrouther, Karl E Kadler, McGrouther Duncan A., Lu, Y., Yinhui Lu, Karl E. Kadler, Al-Youha, S., Sarah Al-Youha, Taylor Susan H., Kadler, K.E., Lu, Yinhui, Tom Van Agtmael, Taylor, S.H., McGrouther, D.A., Susan H. Taylor, Van Agtmael, Tom, Wong, Jason; id_orcid   +31 more
core   +2 more sources

Serum MicroRNA signatures associated with hypertrophic callus formation in polytrauma patients with traumatic brain injury

Scientific Reports
Long-bone fractures occasionally develop excessive callus formation in the presence of traumatic brain injury, a clinically relevant but poorly understood injury response.
Thomas Lettner, Florian Dussing, Renate Gehwolf, Christian Deininger, Amelie Deluca, Verena Wally, Valeska Hofmann, Matthias Hackl, Andreas Traweger, Florian Wichlas   +9 more
doaj   +1 more source

Current Issues and Regulations in Tendon Regeneration and Musculoskeletal Repair with Mesenchymal Stem Cells

, 2011
Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described.
Grange, Simon
core   +1 more source