Results 11 to 20 of about 21,653 (110)
Allergy-induced systemic inflammation impairs tendon quality
EBioMedicine, 2022 Summary: Background: Treatment of degenerating tendons still presents a major challenge, since the aetiology of tendinopathies remains poorly understood.
Christine Lehner +15 more
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In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint
Biomedicines, 2021 Biodegradable and bioresponsive polymer-based nanoparticles (NPs) can be used for oligonucleotide delivery, making them a promising candidate for mRNA-based therapeutics.
Lisa Sturm +10 more
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The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels [PDF]
European Cells & Materials, 2016 Tissue barriers function as “gate keepers” between different compartments (usually blood and tissue) and are formed by specialised membrane-associated proteins, localising to the apicolateral plasma membrane domain of epithelial and endothelial cells. By
C Lehner +7 more
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Interplay of Forces and the Immune Response for Functional Tendon Regeneration
Frontiers in Cell and Developmental Biology, 2021 Tendon injury commonly occurs during sports activity, which may cause interruption or rapid decline in athletic career. Tensile strength, as one aspect of tendon biomechanical properties, is the main parameter of tendon function.
Yuwei Yang +18 more
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Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration
eLife, 2020 Tendon injuries are common with poor healing potential. The paucity of therapies for tendon injuries is due to our limited understanding of the cells and molecular pathways that drive tendon regeneration.
Deepak A Kaji +4 more
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Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1
Disease Models & Mechanisms, 2019 Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined.
Christine Lehner +9 more
doaj +1 more source
Cells, 2019 Tendinopathy is accompanied by a cascade of inflammatory events promoting tendon degeneration. Among various cytokines, interleukin-1β plays a central role in driving catabolic processes, ultimately resulting in the activation of matrix ...
Renate Gehwolf +8 more
doaj +1 more source
Materials Today Bio, 2023 Facilitating regeneration of the tendon-to-bone interface can reduce the risk of postoperative retear after rotator cuff repair. Unfortunately, undesirable inflammatory responses following injury, difficulties in fibrocartilage regeneration, and bone ...
Haihan Gao +8 more
doaj +1 more source
Nature Communications, 2021 The regeneration of functional tendons remains a clinical challenge. Here the authors develop a biomimetic scaffold loaded with recombinant periostin and demonstrate its functionality in promoting tendon stem/progenitor cell recruitment and tenogenic ...
Yu Wang +11 more
doaj +1 more source
A high-glucose diet affects Achilles tendon healing in rats
Scientific Reports, 2017 Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone.
Stefanie Korntner +10 more
doaj +1 more source