Results 21 to 30 of about 21,653 (110)

Biomechanically and biochemically functional scaffold for recruitment of endogenous stem cells to promote tendon regeneration

npj Regenerative Medicine, 2022
Tendon regeneration highly relies on biomechanical and biochemical cues in the repair microenvironment. Herein, we combined the decellularized bovine tendon sheet (DBTS) with extracellular matrix (ECM) from tendon-derived stem cells (TDSCs) to fabricate ...
Jing Cui, Liang-Ju Ning, Fei-Peng Wu, Ruo-Nan Hu, Xuan Li, Shu-Kun He, Yan-Jing Zhang, Jia-Jiao Luo, Jing-Cong Luo, Ting-Wu Qin   +9 more
doaj   +1 more source

The Roles of MicroRNAs in Tendon Healing and Regeneration

Frontiers in Cell and Developmental Biology, 2021
Tendons connect the muscle abdomen of skeletal muscles to the bone, which transmits the force generated by the muscle abdomen contraction and pulls the bone into motion.
Lingli Ding, Min Wang, Shengnan Qin, Liangliang Xu   +3 more
doaj   +1 more source

Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles

Frontiers in Bioengineering and Biotechnology, 2019
Effective regeneration of bone defects often presents significant challenges, particularly in patients with decreased tissue regeneration capacity due to extensive trauma, disease, and/or advanced age.
Darja Marolt Presen, Darja Marolt Presen, Andreas Traweger, Andreas Traweger, Mario Gimona, Heinz Redl, Heinz Redl   +6 more
doaj   +1 more source

Enhancement of Tendon Repair Using Tendon-Derived Stem Cells in Small Intestinal Submucosa via M2 Macrophage Polarization

Cells, 2022
(1) Background: Reconstruction of Achilles tendon defects and prevention of postoperative tendon adhesions were two serious clinical problems. In the treatment of Achilles tendon defects, decellularized matrix materials and mesenchymal stem cells (MSCs ...
Xufeng Mao, Liwei Yao, Mei Li, Xiqian Zhang, Bowen Weng, Weilai Zhu, Renhao Ni, Kanan Chen, Linhua Yi, Jiyuan Zhao, Haijiao Mao   +10 more
doaj   +1 more source

Nanoparticles for tendon healing and regeneration: literature review.

Frontiers in Aging Neuroscience, 2016
Tendon injuries are commonly met in the emergency department. Unfortunately, tendon tissue has limited regeneration potential and usually the consequent formation of scar tissue causes inferior mechanical properties Nanoparticles could be used in ...
Paolo Domenico Parchi, Orazio Vittorio, Orazio Vittorio, Lorenzo Andreani, Pietro Battistini, Stefano Marchetti, Nicola Piolanti, Andrea Poggetti, Michele Lisanti   +8 more
doaj   +1 more source

MicroRNA engineered umbilical cord stem cell-derived exosomes direct tendon regeneration by mTOR signaling

Journal of Nanobiotechnology, 2021
Background Exosomes are extracellular vesicles of nano-structures and represent an emerging nano-scale acellular therapy in recent years. Tendon regeneration is a sophisticated process in the field of microsurgery due to its poor natural healing ability.
Zhixiao Yao, Juehong Li, Hao Xiong, Haomin Cui, Jiexin Ning, Shikun Wang, Xingyu Ouyang, Yun Qian, Cunyi Fan   +8 more
doaj   +1 more source

Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration

Advanced Science, 2023
Tendon‐to‐bone interface has a hierarchical structure and gradient component that are conducive to distributing the stresses to achieve movement. Conventional biomaterials lack the capacity to induce synchronous repair of multiple tissues, resulting in ...
Lin Du, Chen Qin, Hongjian Zhang, Fei Han, Jianmin Xue, Yufeng Wang, Jinfu Wu, Yin Xiao, Zhiguang Huan, Chengtie Wu   +9 more
doaj   +1 more source

Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity

Advanced Science
Tendinopathy is a long‐lasting, debilitating disease that not only affects patients' individual lives, but also imposes a significant socioeconomic burden.
Renate Gehwolf, Herbert Tempfer, Nevra Pelin Cesur, Andrea Wagner, Andreas Traweger, Christine Lehner   +5 more
doaj   +1 more source

Enhanced Effect of Tendon Stem/Progenitor Cells Combined With Tendon-Derived Decellularized Extracellular Matrix on Tendon Regeneration

Cell Transplantation, 2018
Decellularized extracellular matrices have been clinically used for tendon regeneration. However, only a few systematic studies have compared tendon stem/progenitor cells to mesenchymal stromal cells on the tendon-derived decellularized matrix.
Haixin Song, Zi Yin, Tao Wu, Yangzheng Li, Xun Luo, Mingzhu Xu, Lihong Duan, Jianhua Li   +7 more
doaj   +1 more source

Biology and augmentation of tendon-bone insertion repair

Journal of Orthopaedic Surgery and Research, 2010
Surgical reattachment of tendon and bone such as in rotator cuff repair, patellar-patella tendon repair and anterior cruciate ligament (ACL) reconstruction often fails due to the failure of regeneration of the specialized tissue ("enthesis") which ...
Lui PPY, Zhang P, Chan KM, Qin L
doaj   +1 more source