Results 21 to 30 of about 458,172 (134)

Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

Disease Models & Mechanisms, 2019
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined.
Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger   +9 more
doaj   +1 more source

Novel stem cell strategies for tendon regeneration

, 2023
INTRODUCTION Adipose-derived stem cells (ADSCs) are an effective alternative for Teno-regeneration [1]. Despite their applications in tendon engineering, the mechanisms promoting tendon healing still need to be understood.
Guy Wouters, Valentina Russo, Giuseppe Prencipe, Mohammad El Khatib, Arlette Alina Haidar Montes, Barbara Barboni, Annunziata Mauro, Umberto Tosi, Adrian Cervero-Varona, Johannes Stöckl   +9 more
core   +1 more source

Global Responses of Il-1β-Primed 3D Tendon Constructs to Treatment with Pulsed Electromagnetic Fields

Cells, 2019
Tendinopathy is accompanied by a cascade of inflammatory events promoting tendon degeneration. Among various cytokines, interleukin-1β plays a central role in driving catabolic processes, ultimately resulting in the activation of matrix ...
Renate Gehwolf, Bettina Schwemberger, Malik Jessen, Stefanie Korntner, Andrea Wagner, Christine Lehner, Nadja Weissenbacher, Herbert Tempfer, Andreas Traweger   +8 more
doaj   +1 more source

Bi-lineage inducible and immunoregulatory electrospun fibers scaffolds for synchronous regeneration of tendon-to-bone interface

Materials Today Bio, 2023
Facilitating regeneration of the tendon-to-bone interface can reduce the risk of postoperative retear after rotator cuff repair. Unfortunately, undesirable inflammatory responses following injury, difficulties in fibrocartilage regeneration, and bone ...
Haihan Gao, Liren Wang, Zhiqi Lin, Haocheng Jin, Yangbao Lyu, Yuhao Kang, Tonghe Zhu, Jinzhong Zhao, Jia Jiang   +8 more
doaj   +1 more source

A high-glucose diet affects Achilles tendon healing in rats

Scientific Reports, 2017
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone.
Stefanie Korntner, Nadja Kunkel, Christine Lehner, Renate Gehwolf, Andrea Wagner, Peter Augat, Daniel Stephan, Verena Heu, Hans-Christian Bauer, Andreas Traweger, Herbert Tempfer   +10 more
doaj   +1 more source

Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

Nature Communications, 2021
The regeneration of functional tendons remains a clinical challenge. Here the authors develop a biomimetic scaffold loaded with recombinant periostin and demonstrate its functionality in promoting tendon stem/progenitor cell recruitment and tenogenic ...
Yu Wang, Shanshan Jin, Dan Luo, Danqing He, Chunyan Shi, Lisha Zhu, Bo Guan, Zixin Li, Ting Zhang, Yanheng Zhou, Cun-Yu Wang, Yan Liu   +11 more
doaj   +1 more source

The Roles of MicroRNAs in Tendon Healing and Regeneration

Frontiers in Cell and Developmental Biology, 2021
Tendons connect the muscle abdomen of skeletal muscles to the bone, which transmits the force generated by the muscle abdomen contraction and pulls the bone into motion.
Lingli Ding, Min Wang, Shengnan Qin, Liangliang Xu   +3 more
doaj   +1 more source

Biomechanically and biochemically functional scaffold for recruitment of endogenous stem cells to promote tendon regeneration

npj Regenerative Medicine, 2022
Tendon regeneration highly relies on biomechanical and biochemical cues in the repair microenvironment. Herein, we combined the decellularized bovine tendon sheet (DBTS) with extracellular matrix (ECM) from tendon-derived stem cells (TDSCs) to fabricate ...
Jing Cui, Liang-Ju Ning, Fei-Peng Wu, Ruo-Nan Hu, Xuan Li, Shu-Kun He, Yan-Jing Zhang, Jia-Jiao Luo, Jing-Cong Luo, Ting-Wu Qin   +9 more
doaj   +1 more source

Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles

Frontiers in Bioengineering and Biotechnology, 2019
Effective regeneration of bone defects often presents significant challenges, particularly in patients with decreased tissue regeneration capacity due to extensive trauma, disease, and/or advanced age.
Darja Marolt Presen, Darja Marolt Presen, Andreas Traweger, Andreas Traweger, Mario Gimona, Heinz Redl, Heinz Redl   +6 more
doaj   +1 more source

Enhancement of Tendon Repair Using Tendon-Derived Stem Cells in Small Intestinal Submucosa via M2 Macrophage Polarization

Cells, 2022
(1) Background: Reconstruction of Achilles tendon defects and prevention of postoperative tendon adhesions were two serious clinical problems. In the treatment of Achilles tendon defects, decellularized matrix materials and mesenchymal stem cells (MSCs ...
Xufeng Mao, Liwei Yao, Mei Li, Xiqian Zhang, Bowen Weng, Weilai Zhu, Renhao Ni, Kanan Chen, Linhua Yi, Jiyuan Zhao, Haijiao Mao   +10 more
doaj   +1 more source