Biomimetic Scaffolds for Tendon Tissue Regeneration
Biomimetics, 2023 Tendon tissue connects muscle to bone and plays crucial roles in stress transfer. Tendon injury remains a significant clinical challenge due to its complicated biological structure and poor self-healing capacity.
Lvxing Huang +11 more
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Tendon regeneration deserves better: focused review on In vivo models, artificial intelligence and 3D bioprinting approaches [PDF]
Frontiers in Bioengineering and BiotechnologyTendon regeneration has been one of the most challenging issues in orthopedics. Despite various surgical techniques and rehabilitation methods, tendon tears or ruptures cannot wholly regenerate and gain the load-bearing capacity the tendon tissue had ...
Damla Aykora +7 more
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MOFs-Based Nitric Oxide Therapy for Tendon Regeneration
Nano-Micro Letters, 2020 Tendon regeneration is still a great challenge due to its avascular structure and low self-renewal capability. The nitric oxide (NO) therapy emerges as a promising treatment for inducing the regeneration of injured tendon by angiogenesis.
Jun Chen +7 more
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Lymphatic–stem cell crosstalk promotes tendon regeneration via Notch1–Srebp2–mediated cholesterol metabolism [PDF]
Nature CommunicationsTendons, as bradytrophic tissues, exhibit limited healing capacity. The role of lymphatic vessels in tendon regeneration is largely overlooked. By comparing gene expression of the control and injured tendon cells from both neonatal and adult mice, we ...
Liujing Chen +8 more
doaj +2 more sources
Enhancing Tendon Regeneration: Investigating the Impact of Topography on the Secretome of Adipose‐Derived Stem Cells [PDF]
Advanced ScienceTendons are vital for maintaining integrity and movement, but current treatment options are insufficient for their regeneration after injuries. Previous studies have shown that the secretome from mesenchymal stem cells (MSCs) promoted tendon regeneration.
Qiuzi Long +14 more
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PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration [PDF]
Nature CommunicationsTendon injuries are frequently occurring disorders; it is clinically important to enhance tendon regeneration and prevent functional impairment post-injury. While tendon injuries in children heal quickly with minimal scarring, those in adults heal slowly
Atsushi Goto +15 more
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ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration [PDF]
Journal of NanobiotechnologyDiabetic patients exhibit higher tendon injury incidence, with elevated risks of healing failure and re-rupture than healthy individuals, posing major clinical challenges.
Yucheng Gao +13 more
doaj +2 more sources
Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur
Bioengineering, 2023 The aim of this current study was to establish a metaphyseal femoral non-union model in osteoporotic rats by comparing a power tool versus a manual tool for fracture creation. Twelve adult female Sprague Dawley rats were ovariectomized (OVX) and received
Amelie Deluca +8 more
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Allergy-induced systemic inflammation impairs tendon quality
EBioMedicine, 2022 Summary: Background: Treatment of degenerating tendons still presents a major challenge, since the aetiology of tendinopathies remains poorly understood.
Christine Lehner +15 more
doaj +1 more source
In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint
Biomedicines, 2021 Biodegradable and bioresponsive polymer-based nanoparticles (NPs) can be used for oligonucleotide delivery, making them a promising candidate for mRNA-based therapeutics.
Lisa Sturm +10 more
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