Tendon regeneration deserves better: focused review on In vivo models, artificial intelligence and 3D bioprinting approaches [PDF]
Frontiers in Bioengineering and BiotechnologyTendon regeneration has been one of the most challenging issues in orthopedics. Despite various surgical techniques and rehabilitation methods, tendon tears or ruptures cannot wholly regenerate and gain the load-bearing capacity the tendon tissue had ...
Denitsa Docheva +2 more
exaly +4 more sources
Biomimetic Scaffolds for Tendon Tissue Regeneration
Biomimetics, 2023 Tendon tissue connects muscle to bone and plays crucial roles in stress transfer. Tendon injury remains a significant clinical challenge due to its complicated biological structure and poor self-healing capacity.
Hengyi Chen, Junjuan Wang
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Lymphatic–stem cell crosstalk promotes tendon regeneration via Notch1–Srebp2–mediated cholesterol metabolism [PDF]
Nature CommunicationsTendons, as bradytrophic tissues, exhibit limited healing capacity. The role of lymphatic vessels in tendon regeneration is largely overlooked. By comparing gene expression of the control and injured tendon cells from both neonatal and adult mice, we ...
Liujing Chen +8 more
doaj +2 more sources
MOFs-Based Nitric Oxide Therapy for Tendon Regeneration
Nano-Micro Letters, 2020 Tendon regeneration is still a great challenge due to its avascular structure and low self-renewal capability. The nitric oxide (NO) therapy emerges as a promising treatment for inducing the regeneration of injured tendon by angiogenesis.
Yunxia Li, He Xu, Shiyi Chen
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Enhancing Tendon Regeneration: Investigating the Impact of Topography on the Secretome of Adipose‐Derived Stem Cells [PDF]
Advanced ScienceTendons are vital for maintaining integrity and movement, but current treatment options are insufficient for their regeneration after injuries. Previous studies have shown that the secretome from mesenchymal stem cells (MSCs) promoted tendon regeneration.
Qiuzi Long +14 more
doaj +2 more sources
PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration [PDF]
Nature CommunicationsTendon injuries are frequently occurring disorders; it is clinically important to enhance tendon regeneration and prevent functional impairment post-injury. While tendon injuries in children heal quickly with minimal scarring, those in adults heal slowly
Atsushi Goto +15 more
doaj +2 more sources
ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration [PDF]
Journal of NanobiotechnologyDiabetic patients exhibit higher tendon injury incidence, with elevated risks of healing failure and re-rupture than healthy individuals, posing major clinical challenges.
Yucheng Gao +13 more
doaj +2 more sources
Energy‐Supporting Enzyme‐Mimic Nanoscaffold Facilitates Tendon Regeneration Based on a Mitochondrial Protection and Microenvironment Remodeling Strategy [PDF]
Advanced Science, 2022 Tendon injury is a tricky and prevalent motor system disease, leading to compromised daily activity and disability. Insufficient regenerative capability and dysregulation of immune microenvironment are the leading causes of functional loss.
Shikun Wang +7 more
doaj +2 more sources
Macrophage depletion impairs neonatal tendon regeneration [PDF]
FASEB Journal, 2021 Deepak Kaji, Alice Huang, Thomas M Li
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Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur
Bioengineering, 2023 The aim of this current study was to establish a metaphyseal femoral non-union model in osteoporotic rats by comparing a power tool versus a manual tool for fracture creation. Twelve adult female Sprague Dawley rats were ovariectomized (OVX) and received
Amelie Deluca +8 more
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