Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta‐Analysis of Randomized Controlled Trials [PDF]
Brain and BehaviorIntroduction Acute ischemic stroke (AIS) is the most common type of stroke, with increasing incidence and significant healthcare costs. Tenecteplase (TNK), a modified variant of tissue plasminogen activator (tPA), offers advantages such as a longer half ...
Zaryab Bacha +12 more
doaj +4 more sources
Using Tenecteplase for Acute Ischemic Stroke: What Is the Hold Up? [PDF]
Western Journal of Emergency Medicine, 2020 Alteplase is the only Food and Drug Administration-approved intravenous (IV) thrombolytic medication for acute ischemic stroke. However, multiple recent studies comparing tenecteplase and alteplase suggest that tenecteplase is at least as efficacious as ...
Tony Zitek, Ramsey Ataya, Isabel Brea
doaj +3 more sources
IHJ Cardiovascular Case Reports, 2021 A 20-year-old female, with history of mitral valve replacement presented with recent onset breathlessness. Cine fluoroscopy showed restricted leaflet mobility.
Dr A. Shaheer Ahmed +2 more
doaj +2 more sources
Tenecteplase or Alteplase Better in Patients with Acute Ischemic Stroke Due to Large Vessel Occlusion: A Single Center Observational Study [PDF]
Medicina, 2022 Background and Objectives: The study aimed to investigate the efficacy of intravenous thrombolysis with Tenecteplase before thrombectomy for acute ischemic stroke (AIS) patients compared with previous results using Alteplase.
Agnete Teivane +6 more
doaj +3 more sources
Enhancement of Tenecteplase Thrombolytic Actions Ex Vivo and In Vivo by Deoxyribonuclease I [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground We aimed to investigate the phenomenon of thrombolysis resistance in tenecteplase and its underlying causes and evaluate whether DNase‐1 (deoxyribonuclease I) targeting neutrophil extracellular traps (NETs) could enhance the thrombolytic ...
Shuhan Xu +9 more
doaj +2 more sources
Comparison of tenecteplase vs. alteplase in addition to thrombectomy in patients with ischemic stroke caused by large vessel occlusion within 4.5 h: a network meta-analysis [PDF]
Frontiers in NeurologyBackgroundThe optimal reperfusion approach for acute ischemic stroke (AIS) due to large vessel occlusion (LVO) remains under debate. While endovascular thrombectomy (EVT) is the standard treatment, the role of intravenous thrombolysis before EVT ...
Wenkui Li +8 more
doaj +2 more sources
Tenecteplase in large-vessel occlusion with or without thrombectomy: a meta-analysis [PDF]
Frontiers in NeurologyBackgroundDespite the growing adoption of Tenecteplase for stroke thrombolysis, key questions such as the role of bridging therapy and extended-window use in large-vessel occlusion (LVO) patients with or without access to endovascular thrombectomy (EVT ...
Ahmed Alkhiri +9 more
doaj +2 more sources
Tenecteplase versus alteplase for the treatment of acute ischemic stroke: a meta-analysis of randomized controlled trials [PDF]
Annals of MedicineObjectives Tenecteplase, a modified variant of alteplase with greater fibrin specificity and longer plasma half-life, may have better efficacy and safety than alteplase in patients with acute ischemic stroke (AIS).
Jian Huang +4 more
doaj +2 more sources
Role of Tenecteplase in management of acute ischemic stroke: a knowledge, attitude, and practice survey among Indian neurologists [PDF]
, 2021 Background: Tenecteplase, a third generation tissue plasminogen activator has important place in the thrombolytic therapy in acute ischemic stroke. The objective of present study was to understand the knowledge, attitude and practice (KAP) towards the ...
Dhediya, Rajnish M. +2 more
core +3 more sources
Real-world data of tenecteplase vs. alteplase in the treatment of acute ischemic stroke: a single-center analysis [PDF]
Frontiers in NeurologyBackgroundThis retrospective observational cohort study aimed to evaluate whether tenecteplase’s use for acute ischemic stroke (AIS) has time management advantages and clinical benefits.Methods144 AIS patients treated with alteplase and 120 with ...
Yu Yao +6 more
doaj +2 more sources