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Mechanoactive Tenogenic Differentiation of Human Mesenchymal Stem Cells
Tissue Engineering Part A, 2008A mesenchymal stem cell (MSC)-seeded collagen gel under static or dynamic tension is a well-established model to study the potential of MSCs in regenerating a tendon- or ligament-like tissue. Using this model, upregulation of fibrillar collagen mRNA expression and protein production has been demonstrated in response to cyclic tensile mechanical ...
Catherine K, Kuo, Rocky S, Tuan
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Tendon-derived stem cells undergo spontaneous tenogenic differentiation
Experimental Cell Research, 2016Tendon-derived stem cell (TDSC) is a subpopulation of residing stem cells within the intact tendon tissues, with the capacities of self-renewal, clonogenicity, and three-lineage differentiation. Compared with bone marrow derived mesenchymal stem cells (BMSCs), TDSCs are superior for tendon injuries repair as they remain some tendon tissue-specific ...
Jia, Guo +3 more
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Computer Methods and Programs in Biomedicine, 2021
The use of automated systems for image recognition is highly preferred for regenerative medicine applications to evaluate stem cell differentiation early in the culturing state with non-invasive methodologies instead of invasive counterparts. Bone marrow-derived mesenchymal stem cells (BMSCs) are able to differentiate into desired cell phenotypes, and ...
Gözde Dursun +6 more
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The use of automated systems for image recognition is highly preferred for regenerative medicine applications to evaluate stem cell differentiation early in the culturing state with non-invasive methodologies instead of invasive counterparts. Bone marrow-derived mesenchymal stem cells (BMSCs) are able to differentiate into desired cell phenotypes, and ...
Gözde Dursun +6 more
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Injury, 2022
The repair of the tendon-bone interface, which is composed of tendon, fibrocartilage, and bony attachment, remains a clinical challenge. The application of mesenchymal stem cells (MSCs), collagen-rich extracellular matrix (ECMs), as well as growth factors, has the potential to regenerate this special multiple-tissue structure through the so-called ...
Maritha Kumlin +4 more
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The repair of the tendon-bone interface, which is composed of tendon, fibrocartilage, and bony attachment, remains a clinical challenge. The application of mesenchymal stem cells (MSCs), collagen-rich extracellular matrix (ECMs), as well as growth factors, has the potential to regenerate this special multiple-tissue structure through the so-called ...
Maritha Kumlin +4 more
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Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose-derived stem cells [PDF]
Journal of Tissue Engineering and Regenerative Medicine, 2019 Identification of a suitable cell source and bioactive agents guiding cell differentiation towards tenogenic phenotype represents a prerequisite for advancement of cell-based therapies for tendon repair. Human adipose-derived stem cells (hASCs) are a promising, yet intrinsically heterogenous population with diversified differentiation capacities.
Aysegul Dede Eren +2 more
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Tenogenic Differentiation of Ovine Amniotic Stem Cells Co-Cultured with Tenocytes
2013Tendons are constantly exposed to mechanical loads, particularly to injuries in sportsmen, workers, and elderly people. Spontaneous healing, slow and incomplete, often results in scar formation. An effective treatment that is able to stimulate complete tendon healing remains to be developed. The introduction of stem cells that are able to differentiate
CURINI, VALENTINA +6 more
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Journal of Molecular Histology, 2022
The Yes-associated protein (YAP) transcription co-activator is recognized as a key mediator and has been implicated in the regulation of stem cell fate; however, the role of YAP in the tenogenic differentiation of mesenchymal stem cells (MSCs) is not well understood.
Ying Li +5 more
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The Yes-associated protein (YAP) transcription co-activator is recognized as a key mediator and has been implicated in the regulation of stem cell fate; however, the role of YAP in the tenogenic differentiation of mesenchymal stem cells (MSCs) is not well understood.
Ying Li +5 more
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Nanoscale vibration could promote tenogenic differentiation of umbilical cord mesenchymal stem cells
In Vitro Cellular & Developmental Biology - Animal, 2023Regulation of mesenchymal stem cell (MSC) fate for targeted cell therapy applications has been a subject of interest, particularly for tissues such as tendons that possess a marginal regenerative capacity. Control of MSCs' fate into the tendon-specific lineage has mainly been achieved by implementation of chemical growth factors.
Elahe, Karimi +10 more
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Tenogenic differentiation of mesenchymal stem cells and noncoding RNA: From bench to bedside
Experimental Cell Research, 2016Tendon is a critical unit of musculoskeletal system that connects muscle to bone to control bone movement. More population participate in physical activities, tendon injuries, such as acute tendon rupture and tendinopathy due to overuse, are common causing unbearable pain and disability.
Ying-fei, Lu +3 more
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Evaluation of Precise Optimal Cyclic Strain for Tenogenic Differentiation of MSCs
2016Although there are a number of papers relating to tenogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) using uniaxial cyclic stretching stimulation with homogeneous strain field, it has been pretty hard to figure out the optimal normal strain in the stretch direction for the differentiation. In the present study, our group has
Yasuyuki Morita +3 more
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