Results 51 to 60 of about 1,341 (168)
Clinical Endocrinology, Volume 102, Issue 4, Page 482-489, April 2025.ABSTRACT Objective To estimate the incidence, prevalence, patient characteristics and healthcare utilization patterns of moderate to severe thyroid eye disease (TED) in the United States. Design Retrospective review of medical and prescription claims data from the Inovalon deidentified claims database. Patients Patients with moderate to severe TED were
Marius N. Stan +8 more
wiley +1 more source
Teprotumumab for the Treatment of Recalcitrant Thyroid Eye Disease
, 2023 PURPOSETeprotumumab, an insulin-like growth factor 1 receptor monoclonal antibody, is FDA-approved to treat thyroid eye disease (TED). The initial clinical trials excluded patients with previous orbital irradiation, surgery, glucocorticoid use ...
Ugradar, Shoaib +13 more
core +1 more source
Cytokines as Targets of Novel Therapies for Graves’ Ophthalmopathy
Frontiers in Endocrinology, 2021 Graves’ disease (GD) is an organ-specific autoimmune disorder of the thyroid, which is characterized by circulating TSH-receptor (TSH-R) stimulating antibodies (TSAb), leading to hyperthyroidism.
Poupak Fallahi +12 more
doaj +1 more source
The Impact of Monoclonal Antibody Usage on Hearing Outcomes: A Systematic Review
The Laryngoscope, Volume 135, Issue 2, Page 491-506, February 2025.This study assesses the current landscape of the literature regarding ototoxic effects relating to the usage of monoclonal antibodies. Where available, audiometric data are discussed and a proposed mechanism of action for otologic effect is provided. Objective To ascertain trends in ototoxicity observed with monoclonal antibodies (mABs) and understand ...
Priya Arya +5 more
wiley +1 more source
Teprotumumab in thyroid eye disease: wonder drug or great divider?
European Thyroid Journal, 2023 Progress in the management of thyroid eye disease (TED) has bee n slow for many decades. The recent introduction of teprotumumab (TEP) in the t herapeutic arena for TED has had a major impact in view of its efficacy, particularly with respect to its ...
Petros Perros, Laszlo Hegedüs
doaj +1 more source
Frontiers in Endocrinology, 2023 BackgroundsThe effects of various treatments on Graves’ ophthalmopathy (GO) have been studied. As monoclonal antibodies (mAbs) have been proposed for the treatment of moderate to severe GO, direct comparisons between different mAbs are lacking.We ...
Yu Hu +4 more
doaj +1 more source
International Journal of Endocrinology, Volume 2025, Issue 1, 2025.Objective To evaluate the efficacy of combined therapy of compound betamethasone periocular injection and oral mycophenolate mofetil (MMF) in treating active thyroid‐associated ophthalmopathy (TAO). Methods A retrospective study was conducted on 17 patients with active TAO treated with compound betamethasone periocular injection combined with oral MMF ...
Chunchun Xiao +6 more
wiley +1 more source
Laryngoscope Investigative Otolaryngology, Volume 9, Issue 6, December 2024.While orbital decompression is recommended for severe, refractory thyroid eye disease according to the ATA‐ETA Consensus Statement in 2022, there are no clear guidelines regarding the optimal surgical approach. We conducted a survey completed by otolaryngologists that assessed pre‐operative, operative, and post‐operative management preferences for ...
Ryan C. Higgins +2 more
wiley +1 more source
Case Reports in Ophthalmological Medicine, 2022 Retinal surface macrophages play key roles in the regulation of immune response, maintenance of vitreous clarity, and tissue repair. We examined the variation of parafoveal surface macrophages in a thyroid eye disease (TED) patient before and after ...
Oscar Otero-Marquez +5 more
doaj +1 more source
Ocular immune‐related diseases: molecular mechanisms and therapy
MedComm, Volume 5, Issue 12, December 2024.The molecular mechanisms underlying ocular immune‐related diseases is due to the dysregulation of immune responses. The unbalanced activation of diverse immune cell types, inflammatory activators and pathways are related to the immunological pathogenesis of ocular immune‐related disease which paly an essential role of immune processes in the ...
Yakun Wang +5 more
wiley +1 more source