Results 61 to 70 of about 1,426 (171)

Efficacy of Compound Betamethasone Periocular Injection Combined With Oral Mycophenolate Mofetil in Active Thyroid‐Associated Ophthalmopathy: A Pilot Study

International Journal of Endocrinology, Volume 2025, Issue 1, 2025.
Objective To evaluate the efficacy of combined therapy of compound betamethasone periocular injection and oral mycophenolate mofetil (MMF) in treating active thyroid‐associated ophthalmopathy (TAO). Methods A retrospective study was conducted on 17 patients with active TAO treated with compound betamethasone periocular injection combined with oral MMF ...
Chunchun Xiao, Yiwei Liu, Wan Zhou, Yan Xing, Shandong Ye, Bin Huang, Suraiya Saleem   +6 more
wiley   +1 more source

Otolaryngologist surgical preferences for orbital decompression in thyroid eye disease: A North American survey

Laryngoscope Investigative Otolaryngology, Volume 9, Issue 6, December 2024.
While orbital decompression is recommended for severe, refractory thyroid eye disease according to the ATA‐ETA Consensus Statement in 2022, there are no clear guidelines regarding the optimal surgical approach. We conducted a survey completed by otolaryngologists that assessed pre‐operative, operative, and post‐operative management preferences for ...
Ryan C. Higgins, Ciaran F. Lane, Neerav Goyal   +2 more
wiley   +1 more source

Ocular immune‐related diseases: molecular mechanisms and therapy

MedComm, Volume 5, Issue 12, December 2024.
The molecular mechanisms underlying ocular immune‐related diseases is due to the dysregulation of immune responses. The unbalanced activation of diverse immune cell types, inflammatory activators and pathways are related to the immunological pathogenesis of ocular immune‐related disease which paly an essential role of immune processes in the ...
Yakun Wang, Shangze Gao, Fan Cao, Hui Yang, Fengyang Lei, Shengping Hou   +5 more
wiley   +1 more source

Towards targeted Cas9 (CRISPR‐Cas) delivery: Preparation of IgG antibody‐Cas9 conjugates using a split intein

Journal of Peptide Science, Volume 30, Issue 7, July 2024.
Precise cellular targeting will expand the potential of CRISPR‐Cas‐mediated gene editing. For linking the large Cas9 enzyme to IgG antibodies as prime targeting devices, protein trans‐splicing under non‐reducing conditions is shown to efficiently form the desired conjugate from the separately produced and purified entities, providing the first step of ...
Tim Pasch, Nicole Bäumer, Sebastian Bäumer, Frank Buchholz, Henning D. Mootz   +4 more
wiley   +1 more source

Rapid response of thyroid eye disease, peripheral edema, and acropathy to teprotumumab infusion

American Journal of Ophthalmology Case Reports
Purpose: We present a case of rapid improvement in symptoms of thyroid eye disease and amelioration of worsening peripheral edema and acropathy with infusion of teprotumumab, a monoclonal antibody targeting the insulin-like growth factor-1 receptor ...
David A. Kelly, Roger E. Turbin
doaj   +1 more source

The circulating IL‐35+ regulatory B cells are associated with thyroid associated opthalmopathy

Immunity, Inflammation and Disease, Volume 12, Issue 5, May 2024.
The percentage of circulating IL‐35+Bregs was elevated in thyroid‐associated ophthalmopathy (TAO), and the increase was positively correlated with disease activity. IL‐35 significantly prompted the induction of IL‐35+Bregs in healthy controls, but the B cells in TAO showed potential impairment in the transition of B cells towards IL‐35+Breg phenotype ...
Qian Li, Cuixia Yang, Cheng Liu, Yuehui Zhang, Ningyu An, Xiumei Ma, Yang Zheng, Xiaomin Cui, Qian Li   +8 more
wiley   +1 more source

Rescuing Drugs That are Discontinued in Adult Oncology Development for the Benefit of Children and Adolescents With Cancer – An ACCELERATE Multistakeholder Consensus

Clinical Pharmacology &Therapeutics, Volume 115, Issue 1, Page 36-41, January 2024.
Better therapies for childhood cancer remain an unmet need to improve the dismal prognosis of certain malignancies and to reduce the burden of toxicity. Rescuing discontinued or shelved drugs for children, adolescents, and young adults is a strategy to identify new uses for approved or investigational medicines outside the scope of their original ...
Teresa de Rojas, Davy Chiodin, Andrew D.J. Pearson, Delphine Heenen, Peter Adamson, Hubert Caron, Gilles Vassal   +6 more
wiley   +1 more source

Comparative Efficacy of Medical Treatments for Thyroid Eye Disease: A Network Meta-Analysis

Journal of Ophthalmology, 2018
Purpose. Numerous medical strategies have been proposed for the treatment of thyroid eye disease (TED); however, the best methods for standard treatment are still a matter of controversy.
Nuo Xu, Yi Cui, Tianlu Xie, Mi Zheng
doaj   +1 more source

Outcomes of Strabismus Surgery Following Teprotumumab Therapy

PURPOSE: To investigate the results of patients undergoing surgical treatment for strabismic diplopia in thyroid eye disease (TED) following teprotumumab. DESIGN: Multicenter, retrospective, case series.
Peragallo, Jason H, Pruett, Jaron, Ditta, Lauren, Kuo, Annie F, Tavakoli, Mehdi, Indaram, Maanasa, Hilliard, Grant, Velez, Federico G, Kerr, Natalie C, Hoehn, Mary E, Donahue, Sean P   +10 more
core   +1 more source

Teprotumumab divergently alters fibrocyte gene expression: Implications for thyroid-associated ophthalmopathy

, 2022
Research report supplemental figure.Context: Teprotumumab, an IGF-I receptor inhibitor (IGF-IR), is effective in thyroid-associated ophthalmopathy (TAO).
Smith, Terry
core   +1 more source