Results 101 to 110 of about 48,551 (323)

Dose-Dependent Teratogenicity of the Synthetic Cannabinoid CP-55,940 in Mice

Neurotoxicology and Teratology, 2015
Potent synthetic cannabinoids (SCBs) are illegally distributed drugs of abuse that are frequently consumed in spite of their adverse consequences. This study was designed to determine if the toxicity observed in adults also extends to the prenatal period
M. T. Gilbert, K. Sulik, E. W. Fish, Lorinda K. Baker, D. B. Dehart, S. Parnell   +5 more
semanticscholar   +1 more source

A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression. [PDF]

, 2000
peer reviewedValproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species.
Hostick, U., Hofmann, C., BALLING, Rudi, Boncinelli, E., Consalez, G. G., Faiella, A., Wernig, M., Hustert, E., Nadeau, J. H.   +8 more
core   +1 more source

Treatment for nausea and vomiting in pregnant women [PDF]

Farmacja Polska
Nausea and vomiting of pregnancy (NVP), associated as „morning sickness”, is a problem faced by approximately 70% of pregnant women. The exact mechanism of NVP is not known, research suggests that growth and differentiation factor 15 (GDF 15) secreted by
Józef Muszyński, Jakub Brzozowski, Katarzyna Dettlaff   +2 more
doaj   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Update on the Teratogenicity of Maternal Mycophenolate Mofetil

Journal of Pediatric Genetics, 2015
Mycophenolic acid (MPA) products, namely mycophenolate mofetil and mycophenolate sodium, are immunosuppressive medications used to prevent rejection in solid organ transplant recipients and to treat various autoimmune disorders.
L. Coscia, D. Armenti, R. King, N. Sifontis, S. Constantinescu, M. Moritz   +5 more
semanticscholar   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, EarlyView.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source

Comparative teratogenicity analysis of valnoctamide, risperidone, and olanzapine in mice

Bipolar Disorders, 2015
Based on the recent findings from animal studies, it has been proposed that the therapeutic use of valnoctamide, an anxiolytic drug developed in the early 1960s, be extended to treat other neurological disorders such as epilepsy and bipolar disease ...
Bogdan J. Wlodarczyk, K. Ogle, Li Lin, M. Bialer, R. Finnell   +4 more
semanticscholar   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse [PDF]

, 2017
The aims of the research were to establish whether diphenylhydantoin and phenobarbitone are teratogenic in mice both in vivo and in an in vitro whole embryo culture system, to investigate possible mechanisms of teratogenicity and to examine whether the ...
Beyers, Nulda
core   +1 more source

The teratogenicity of the newer antiepileptic drugs – an update

Acta Neurologica Scandinavica, 2014
To assess the risk of teratogenicity from maternal intake of the more widely used newer antiepileptic drugs, especially lamotrigine, levetiracetam and topiramate.
F. Vajda, Terence O'Brien, C. Lander, J. Graham, M. Eadie   +4 more
semanticscholar   +1 more source