Results 91 to 100 of about 48,551 (323)

Nonclinical teratogenicity safety assessment of CRBN-engaging targeted protein degraders: Points to consider. [PDF]

Targeted protein degraders (or degraders) are an emerging small molecule drug modality with transformative therapeutic potential. Currently, most degraders are developed for severe life-threatening disorders and engage the E3 ligase cereblon. One barrier
Hemkens, Michelle, DeLise, Anthony, Cauvin, Annick, Stamp, Katie, Burdick, Andrew D., Zane, Doris T., Loberg, Lisa I., Hukkanen, Renee, Hohlbaum, Andreas M., Sdgwick, Alanna E., Shuey, Dana, Proctor, William R.   +11 more
core   +1 more source

Valproic Acid Teratogenicity: A Toxicogenomics Approach [PDF]

, 2004
Embryonic development is a highly coordinated set of processes that depend on hierarchies of signaling and gene regulatory networks, and the disruption of such networks may underlie many cases of chemically induced birth defects.
Birger Scholz, Dencker, Lennart, Kultima, Kim, Stigson, Michael, Scholz, Birger,, Nyström, Anna-Maja,, Nyström, Anna-Maja, Gustafson, Anne-Lee,, Lennart Dencker, Gustafson, Anne-Lee, Dencker, Lennart,, Anne-Lee Gustafson, Kim Kultima, Anna-Maja Nyström, Stigson, Michael,, Michael Stigson, Scholz, Birger, Kultima, Kim,   +17 more
core   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

Scientific Reports, 2016
Angiogenesis, the formation of new blood vessels, is essential for tumor growth, stabilization and progression. Angiogenesis inhibitors are now widely used in the clinic; however, there are relatively few published studies on the mechanism of their ...
Shaunna L. Beedie, Chris Mahony, Heather M. Walker, C. Chau, W. Figg, N. Vargesson   +5 more
semanticscholar   +1 more source

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source

Increased Susceptibility to Phenytoin Teratogenicity: Excessive Generation of Reactive Oxygen Species or Impaired Antioxidant Defense? [PDF]

, 2006
Phenytoin is a human and animal teratogen. Accumulating evidence suggests that the teratogenicity is associated with a potential of phenytoin to cause embryonic cardiac arrhythmia and resultant generation of toxic reactive oxygen species via hypoxia ...
Bengt R. Danielsson, Borg, L. A. Håkan,, L. A. Håkan Borg, Faranak Azarbayjani, Danielsson, Bengt R.,, Azarbayjani, Faranak,   +5 more
core   +1 more source

Teratogenicity of Ochratoxin A and the Degradation Product, Ochratoxin α, in the Zebrafish (Danio rerio) Embryo Model of Vertebrate Development

Toxins, 2016
Ochratoxins, and particularly ochratoxin A (OTA), are toxic fungal-derived contaminants of food and other agricultural products. Growing evidence supports the degradation of OTA by chemical, enzymatic and/or microbial means as a potential approach to ...
Mehreen Haq, Nelson Gonzalez, Keenan Mintz, Asha Jaja-Chimedza, Christopher Lawrence De Jesus, Christina Lydon, Aaron Z. Welch, John P. Berry   +7 more
doaj   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Assessment of polyaniline nanoparticles toxicity and teratogenicity in aquatic environment using Rhinella arenarum model.

Ecotoxicology and Environmental Safety, 2015
With the rapid growth of nanotechnology and the applications of nanoparticles, environmental exposure to these particles is increasing. However, their impact in human and environmental health is not well studied.
L. Ibarra, Lucrecia Tarres, Silvestre Bongiovanni, C. Barbero, M. Kogan, V. Rivarola, M. Bertuzzi, E. Yslas   +7 more
semanticscholar   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source