Results 81 to 90 of about 21,579 (291)

Focus on germ-layer markers : A human stem cell-based model for in vitro teratogenicity testing

, 2020
Human induced pluripotent stem cells (hiPSC) were used to develop an assay format that may deliver information on teratogenicity of drugs. A human pluripotent stem cell scorecard panel was used to monitor the expression of 96 marker genes that are ...
Ebeling, Martin, Kustermann, Stefan, Jaklin, Manuela, Leist, Marcel, Clemann, Nicole, Barrow, Paul, Zhang, Jitao David, Manuela Jaklin, Nicole Clemann, Marcel Leist, Jitao David Zhang, Martin Ebeling, Paul Barrow, Stefan Kustermann   +13 more
core   +1 more source

Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care

Epilepsia Open, EarlyView.
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley, Peter Widdess‐Walsh, Christine Linehan, Danielle M. Andrade, Norman Delanty, Patrick B. Moloney   +5 more
wiley   +1 more source

EVALUATION OF EMBRYOTROPIC PROPERTIES OF THE ANTHELMINTIC MITRANOX

Российский паразитологический журнал, 2016
Objective of research: to estimate the potential embryotropic properties of the anthelmintic Mitranox. Materials and methods: the experiments were conducted on 70 white outbreed pregnant rats divided into one control and 6 experimental groups (10 animals
S. A. Kozlov, M. B Musaev
doaj   +1 more source

Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice [PDF]

, 2016
Potent synthetic cannabinoids (SCBs) are illegally distributed drugs of abuse that are frequently consumed in spite of their adverse consequences. This study was designed to determine if the toxicity observed in adults also extends to the prenatal period
Baker, Lorinda K., Dehart, Deborah B., Parnell, Scott E., Fish, Eric W., Gilbert, Marcoita T., Sulik, Kathleen K.   +5 more
core   +1 more source

Comprehensive Review on Advancements in Food Preservation Technologies for Quality and Sustainability

Food Chemistry International, EarlyView.
Preservatives limit microbial development, oxidation, and enzymatic degradation, resulting in better food quality and extended shelf life. Classified as natural, synthetic, or biological, each preservative has distinctive attributes and modes of action. Growing preference for natural preservatives aligns with clean label trends.
Monica Suresh, Arun Meyyazhagan, Haripriya Kuchi Bhotla, Manikantan Pappuswamy, Balamuralikrishnan Balasubramanian   +4 more
wiley   +1 more source

Food Safety Management and Mycotoxins Nexus: A Systematic Review of Mycotoxins Toxicity, Detoxification, Nutritional Impacts, and Economic Importance

Food Safety and Health, EarlyView.
The graphical abstract illustrates the interconnected relationship between food safety management, mycotoxin toxicity, and detoxification strategies, highlighting how preventive measures across the food chain can minimize mycotoxin contamination and reduce adverse health effects in humans/animals.
Chinaza Godswill Awuchi
wiley   +1 more source

TERATOGENIC RISK ASSESSMENT OF POTASSIUM BENZOATE EXPOSURE DURING PREGNANCY IN ALBINO RATS [PDF]

The Egyptian Journal of Forensic Sciences and Applied Toxicology
Background: For centuries, people have employed food additives to add artificial flavours and raise the standard of food and beverages. Potassium benzoate is a widely used preservative with unexplored reproductive and teratogenic safety.
Eman Shaltout, Safaa George, Ghada Mohamed, Merry Shenouda, Marwa Mohammed   +4 more
doaj   +1 more source

Vaccinations in pregnancy: An update for a changing time

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Maternal immunization is one of the most effective public health interventions to reduce infectious morbidity and mortality in pregnant women, fetuses, and newborns. Despite robust evidence supporting vaccine safety and effectiveness in pregnancy, global uptake has declined following the COVID‐19 pandemic, contributing to resurgent outbreaks ...
Wendy Hodge, Méabh Bhuinneáin, Gelila Goba, Marisa Labovsky, Eliana Amaral, Asma Khalil, David Lissauer, Hema Divakar, Fionnuala M. McAuliffe, Deborah Money, Dharmintra Pasupathy, on behalf of the FIGO Committee on Infections During Pregnancy   +11 more
wiley   +1 more source

Prevention of Epilepsy and Complications

Pediatric Neurology Briefs, 1995
Prevention of epilepsy and its consequencies is discussed in a special article from the Department of Neurology, School of Medicine, University of Virginia, Charlottesville.
J Gordon Millichap
doaj   +1 more source

Therapeutic orphans no more: Revisiting the ethical justification for excluding pregnant women from pharmaceutical clinical trials

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract For six decades, pregnant women have been routinely excluded from pharmaceutical clinical trials, a practice rooted in a protectionist ethic that emerged after the thalidomide tragedy. This narrative review examines whether that exclusion remains ethically justifiable, drawing on the obstetric, pharmacological, and bioethical literature ...
Camila Kruger Cabar, Fábio Roberto Cabar   +1 more
wiley   +1 more source