Results 71 to 80 of about 21,579 (291)

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

Phase‐Change‐Activated Slippery Organogel Composite for All‐in‐One Anti‐Corrosion, Antifouling, and Self‐Cleaning

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A super‐slippery liquid‐infused composite organogel is engineered by localized interfacial grafting between hydrogel and oleogel networks, endowing the coating with a durable, multifunctional marine‐protective interface. Dynamic antifouling surfaces have emerged as a promising alternative, offering the potential for eco‐friendly and high‐performance ...
Mengsheng Xia, Chao Wang, Jiahao Ma, Jiwei Chen, Yixi Su, Junkai Gao, Weiqi Fu   +6 more
wiley   +1 more source

Caffeine teratogenicity in rats: morphological characterization and hypothesized mechanisms [PDF]

, 2016
Caffeine consumption during pregnancy has been shown in the scientific literature to be associated with teratogenicity such as low birth weight, fetal malformations, and miscarriage. However, the morphological alterations of the offspring of dams exposed
Souza, Ana Claudia, Andressa Souza, Torres, Iraci Lucena da Silva, Jairo Alberto Dussán-Sarria, Ana Claudia Souza, Souza, Andressa, Dussán-Sarria, Jairo Alberto, Souza, Andressa de, Ana Cláudia de Souza, Iraci Lucena da Silva Torres, Caumo, Wolnei, Andressa de Souza, Souza, Ana Cláudia de, Sarria, Jairo Alberto Dussán, Wolnei Caumo   +14 more
core   +1 more source

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Study on teratogenicity of Pandanus amaryllifolius Roxb. powder in rats

, 2020
Objective To evaluate whether the Pandanus amaryllifolius Roxb. powder had reproductive toxicity to the SD rat and whether it was teratogenic to theembryo, perform toxicological evaluation of its safety, and provide the basis of the toxicology safety for
Dingshan FENG, Aiqin WU, Linliang SU, Weihua LIN, Yeyu HUANG, Xiaoxin ZHANG, Zhan WANG   +6 more
core   +1 more source

A British Pharmacological Society Position Statement on Medications in Pregnancy and Lactation

British Journal of Clinical Pharmacology, EarlyView.
Agnesa Mustafa, Cleodie C. Swire, Reya V. Shah, Bernadette Jenner, Rory H. McLean, Muhammad Shamsher Ahmed, Adrie Bekker, Julia Zöllner, Rachel K. Scott, Robert R. Bies, Sara K. Quinney, Dagan O. Lonsdale, Emma Forton Magavern, Catriona Waitt, Anita Banerjee   +14 more
wiley   +1 more source

Epilepsy with eyelid myoclonia beyond the classical phenotype: Longitudinal electroclinical observations in a pediatric cohort

Epileptic Disorders, EarlyView.
Abstract Objective Epilepsy with eyelid myoclonia is a childhood‐onset generalized epilepsy syndrome with variable recognition of eyelid myoclonia, eye‐closure sensitivity, and photosensitivity during follow‐up. We aimed to characterize longitudinal clinical and electroencephalographic features in pediatric epilepsy with eyelid myoclonia, focusing on ...
Hande Aygün, Alper Taşkın, Özlem Yayıcı Köken, Şenay Haspolat   +3 more
wiley   +1 more source

Clinical case of Spina bifida in a Child Born to a Mother with Epilepsy Receiving Carbamazepine

Неврология, нейропсихиатрия, психосоматика, 2014
This article presents a literature review on teratogenic effects of carbamazepine and a clinical case of spina bifida in a child whose mother had epilepsy and was receiving carbamazepine during pregnancy.
E. O. Ovchinnikova, M. B. Mironov, K. Yu. Mukhin, T. M. Krasil’shchikova, D. N. Smirnov   +4 more
doaj   +1 more source

Treatment adherence in bipolar disorder

Psychiatry and Behavioral Sciences, 2011
Purpose: A high level of treatment adherence is essential in patients with bipolar disorder for effective treatment, due to chronic progressive nature of the illness requiring maintenance treatment.
Haluk A. Savaş, Ahmet Unal, Osman Vırıt   +2 more
doaj   +1 more source

Increased Susceptibility to Phenytoin Teratogenicity: Excessive Generation of Reactive Oxygen Species or Impaired Antioxidant Defense?

, 2006
Phenytoin is a human and animal teratogen. Accumulating evidence suggests that the teratogenicity is associated with a potential of phenytoin to cause embryonic cardiac arrhythmia and resultant generation of toxic reactive oxygen species via hypoxia ...
Bengt R. Danielsson, Borg, L. A. Håkan,, L. A. Håkan Borg, Faranak Azarbayjani, Danielsson, Bengt R.,, Azarbayjani, Faranak,   +5 more
core   +1 more source