Results 51 to 60 of about 48,551 (323)

Effects of Prenatal Exposure to Aflatoxin B1: A Review

Molecules, 2021
Aflatoxins are mycotoxins produced as secondary fungal metabolites. Among them, aflatoxin B1 (AFB1) stands out due to its genotoxic and mutagenic potential, being a potent initiator of carcinogenesis.
João Victor Batista da Silva, Carlos Augusto Fernandes de Oliveira, Leandra Náira Zambelli Ramalho   +2 more
doaj   +1 more source

Are female bipolar patients of reproductive age aware of the teratogenic risk of sodium valproate? A qualitative study

South African Journal of Psychiatry, 2022
Background: Sodium valproate is considered the most teratogenic of all anticonvulsant drugs. Internationally, new regulations require women to sign risk assessment forms if initiated on it.
Amanda U. Sibanyoni, Marinda Joubert, Kalaivani Naidu   +2 more
doaj   +1 more source

Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos

BMC Pharmacology and Toxicology, 2017
Background Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline ...
Ram Manohar Basnet, Daniela Zizioli, Michela Guarienti, Dario Finazzi, Maurizio Memo   +4 more
doaj   +1 more source

Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells

Reproductive Toxicology, 2019
Pluripotent stem cells recapitulate many aspects of embryogenesis in vitro. Here, we established a novel culture system to differentiate human embryonic stem cell aggregates (HESCA), and evaluated its utility for teratogenicity assessment.
Y. Marikawa, Hong‐Ru Chen, Mark Menor, Youping Deng, V. B. Alarcon   +4 more
semanticscholar   +1 more source

Phenytoin and Carbamazepine Teratogenicity

Pediatric Neurology Briefs, 1997
In a prospective, controlled, and blinded study of 36 mother-child pairs exposed to carbamazepine (CBZ) monotherapy, 34 pairs exposed to phenytoin (DPH) monotherapy, and 9 nonmedicated epileptic women and their children, the patterns of malformations in ...
J Gordon Millichap
doaj   +1 more source

Restrictions on the use of valproate in female patients of reproductive age: the updated recommendations based on recent clinical data

Эпилепсия и пароксизмальные состояния, 2019
For more than half a century, valproic acid (VA) has been a first-line drug to control seizures in various forms of epilepsy and status epilepticus; VA is also used in bipolar disorders.
G. N. Avakyan, D. V. Blinov, G. G. Avakyan, E. S. Akarachkova, S. G. Burd, P. N. Vlasov, K. V. Voronkova, V. I. Guzeva, I. A. Zhidkova, E. A. Katunina, D. I. Korabelnikov, A. V. Lebedeva, L. V. Lipatova, E. A. Morozova, O. M. Oleinikova, I. G. Rudakova   +15 more
doaj   +1 more source

Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity.

Acta Dermato-Venereologica, 2017
Isotretinoin (13-cis retinoic acid) is the most effective sebum-suppressive drug for the treatment of severe acne. Its effect depends on sebocyte apoptosis, which results from isotretinoin-induced expression of the apoptotic protein tumour necrosis ...
B. Melnik
semanticscholar   +1 more source

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

eLife, 2018
In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment ...
Katherine A Donovan, Jian An, Radosław P Nowak, Jingting C Yuan, Emma C Fink, Bethany C Berry, Benjamin L Ebert, Eric S Fischer   +7 more
doaj   +1 more source

Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity

Cell Stem Cell, 2019
SUMMARY Human pluripotent stem cells can be rapidly converted into functional neurons by ectopic expression of proneural transcription factors.
Soham Chanda, C. Ang, Qian Yi Lee, Michael Ghebrial, Daniela Haag, Yohei Shibuya, Marius Wernig, T. Südhof   +7 more
semanticscholar   +1 more source

Machine learning on drug-specific data to predict small molecule teratogenicity

bioRxiv, 2019
Pregnant women are an especially vulnerable population, given the sensitivity of a developing fetus to chemical exposures. However, prescribing behavior for the gravid patient is guided on limited human data and conflicting cases of adverse outcomes due ...
A. Challa, A. Beam, M. Shen, Tyler Peryea, R. Lavieri, E. Lippmann, D. Aronoff   +6 more
semanticscholar   +1 more source