Results 31 to 40 of about 21,579 (291)

Impact of educational session on knowledge and attitude towards teratogenicity among undergraduate medical students: a comparative study [PDF]

, 2017
Background: Teratogenicity is a major cause of abortion, still birth and can result in longterm disability with a significant impact on individuals, families, societies and healthcare systems.
Krishnaiah, Vasundara, Tamboli, Tushar J., Tushar J. Tamboli, Priyanka Kumari, Vasundara Krishnaiah, Kumari, Priyanka, Kumaraswamy, Girish, Girish Kumaraswamy   +7 more
core   +1 more source

Optimization of the TeraTox assay for preclinical teratogenicity assessment [PDF]

, 2022
Current animal-free methods to assess teratogenicity of drugs under development still deliver high numbers of false negatives. To improve the sensitivity of human teratogenicity prediction, we characterized the TeraTox test, a newly developed ...
Schäfer, Nicole, Kustermann, Stefan, Jaklin, Manuela, Leist, Marcel, Clemann, Nicole, Küng, Erich, Barrow, Paul, McGinnis, Claudia, Sach-Peltason, Lisa, Zhang, Jitao David, Claudia McGinnis, Nicole Schäfer, Erich Küng, Manuela Jaklin, Nicole Clemann, Marcel Leist, Jitao David Zhang, Lisa Sach-Peltason, Paul Barrow, Stefan Kustermann   +19 more
core   +1 more source

Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos

BMC Pharmacology and Toxicology, 2017
Background Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline ...
Ram Manohar Basnet, Daniela Zizioli, Michela Guarienti, Dario Finazzi, Maurizio Memo   +4 more
doaj   +1 more source

A Precision‐Delivered Singlet Oxygen Generator With an Inbuilt Safety Switch for Induction of Pancreatic Beta Cell Stress and Death

Angewandte Chemie, EarlyView.
ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann, Owen Bendor‐Samuel, Christopher Carlein, Kaja Rupar, Leticia Prates Roma, Ramona Birke, Tolga Soykan, Ingo Breng, Andreas Oder, Iona Davies, Ben Jones, Alice Adriaenssens, Michelle M. Martinez Irizarry, Rachael Morara, Martin Lehmann, Amelia K. Linnemann, David J. Hodson, Johannes Broichhagen   +17 more
wiley   +2 more sources

Restrictions on the use of valproate in female patients of reproductive age: the updated recommendations based on recent clinical data

Эпилепсия и пароксизмальные состояния, 2019
For more than half a century, valproic acid (VA) has been a first-line drug to control seizures in various forms of epilepsy and status epilepticus; VA is also used in bipolar disorders.
G. N. Avakyan, D. V. Blinov, G. G. Avakyan, E. S. Akarachkova, S. G. Burd, P. N. Vlasov, K. V. Voronkova, V. I. Guzeva, I. A. Zhidkova, E. A. Katunina, D. I. Korabelnikov, A. V. Lebedeva, L. V. Lipatova, E. A. Morozova, O. M. Oleinikova, I. G. Rudakova   +15 more
doaj   +1 more source

apchalla/teratogenicity-qsar: teratogenicity-qsar

, 2019
This release contains supplemental code and data files for the publication "Machine learning on drug-specific data to predict small molecule teratogenicity" by Challa et ...
Anup P. Challa
core   +1 more source

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

eLife, 2018
In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment ...
Katherine A Donovan, Jian An, Radosław P Nowak, Jingting C Yuan, Emma C Fink, Bethany C Berry, Benjamin L Ebert, Eric S Fischer   +7 more
doaj   +1 more source

Paroxetine overdose during pregnancy

Forensic Sciences Research, 2021
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression and anxiety disorders. In some epidemiological studies, slightly increased risks of major malformations and cardiac malformations have been reported ...
Selin Acar, Hilal Erol, Elif Keskin Arslan, Nusret Uysal, Barış Karadaş, Tijen Kaya Temiz, Yusuf Cem Kaplan   +6 more
doaj   +1 more source

Mycotoxicity and embryonic development: I- Aflatoxin B1 reduces quality and birth rate during mice embryonic development

SVU-International Journal of Veterinary Sciences, 2023
Mycotoxins are fungal products often found in food, formed during growth, harvesting, drying or storage of fruits, seeds, or grains, leading to a variety of toxic effects in humans and animals.
Reda A. Ali , fatma khalil , Hemely A. Hassan, Inas M. Amer, Zeinab Kamal   +4 more
doaj   +1 more source

Embryotoxicity and Teratogenicity of Steroidal Saponin Isolated from Ophiopholis mirabilis

, 2023
Benthic invertebrates produce secondary metabolites that serve as defenses against consumers and promote their fitness. To explore the chemical defense in marine benthic echinoderms, the chemical constituents of Ophiopholis mirabilis were investigated. A
Yanfang Liu, Zhi Yan, Bing Ma, Xiao Yang, Qian Xu, Li Chen, Xiaodong Li, Ranran Zhang, Ainuo Lin, Ke Li, Shaoshuai Han, Yaxi Li, Li, Yaxi, Ma, Bing, Li, Ke, Lin, Ainuo, Xu, Qian, Li, Xiaodong, Zhang, Ranran, Chen, Li, Yang, Xiao, Han, Shaoshuai, Yan, Zhi, Liu, Yanfang   +23 more
core   +1 more source