In vitro teratogenicity testing using a 3D, embryo-like gastruloid system [PDF]
Reproductive Toxicology, 2021 Pharmaceuticals that are intended for use in patients of childbearing potential need to be tested for teratogenicity before marketing. Several pharmaceutical companies use animal-free in vitro models which allow a more rapid selection of lead compounds ...
Stefan Kustermann +2 more
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Mutagenicity and teratogenicity studies of vitacoxib in rats and mice [PDF]
Toxicology Reports, 2018 Vitacoxib is a new drug candidate for treatment of inflammation, pain and fever as selective cyclooxygenase-2 inhibitors. In the current study, the mice sperm abnormality, mammalian erythrocyte micronucleus and in vivo chromosome aberration, and ...
Feifei Sun +2 more
exaly +4 more sources
The teratogenicity of allopurinol: A comprehensive review of animal and human studies [PDF]
Reproductive Toxicology, 2018 Allopurinol is widely used in the management of multiple disorders including gout, kidney stones and inflammatory bowel disease. Despite of long-term experience, its safety in pregnancy has been debated due to reports on possible teratogenicity. We aimed
Nanne De Boer, Melek Simsek
exaly +3 more sources
Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms [PDF]
Journal of Ethnopharmacology, 2012 ETHNOPHARMACOLOGICAL RELEVANCE The increasing use of traditional herbal medicines around the world requires more scientific evidence for their putative harmlessness. To this end, a plethora of methods exist, more or less satisfying.
Feng Lin, Pierre Duez, Thomas Efferth
exaly +4 more sources
Genetic Susceptibility to Drug Teratogenicity: A Systematic Literature Review [PDF]
Frontiers in Genetics, 2021 Since the 1960s, drugs have been known to cause teratogenic effects in humans. Such teratogenicity has been postulated to be influenced by genetics. The aim of this review was to provide an overview of the current knowledge on genetic susceptibility to ...
J. A. Gomes +6 more
semanticscholar +3 more sources
Teratogenicity with olanzapine
Indian Journal of Psychological Medicine, 2014 Olanzapine, a 2 nd generation antipsychotic, is in use in the clinical practice for nearly a decade and a half now. It is classified as a category C drug with very few reports of its toxic effects on the fetus.
Sathya Prakash, Rakesh Kumar Chadda
doaj +4 more sources
Effects of Specific Dosages of Magnesium and Zinc on the Teratogenicity of Cadmium, Nickel, and Cobalt in Embryos, as Assessed by the Fetax Test [PDF]
Dose-Response, 2008 The objective of this study was to determine if exposure to divalent cations, Cd 2+ , Ni 2+ , and Co 2+ would lead to malformations in Xenopus laevis embryos, and whether addition of Mg 2+ and Zn 2+ ; separately and in combination, would reduce their ...
Ayper Boga PhD, Seref Erdogan, MD +1 more
doaj +2 more sources
Establishing the teratogenicity of Zika and evaluating causal criteria [PDF]
Synthese, 2018 The teratogenicity of the Zika virus was considered established in 2016, and is an interesting case because three different sets of causal criteria were used to assess teratogenicity.
Jon Williamson
semanticscholar +3 more sources
Medical databases in studies of drug teratogenicity: methodological issues [PDF]
Clinical Epidemiology, 2010 Vera Ehrenstein1, Henrik T Sørensen1, Leiv S Bakketeig1,2, Lars Pedersen11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Norwegian Institute of Public Health, Oslo, NorwayAbstract: More than half of all ...
Vera Ehrenstein +3 more
doaj +1 more source
Teratogenicity of antiepileptic drugs [PDF]
Current Opinion in Neurology, 2019 Purpose of review We review data on the comparative teratogenicity of antiepileptic drugs (AEDs), focusing on major congenital malformations (MCMs), intrauterine growth restriction, impaired cognitive development, and behavioral adverse effects following
T. Tomson, D. Battino, E. Perucca
semanticscholar +2 more sources