Results 61 to 70 of about 21,579 (291)

When meta‐analyses mislead: Promises and pitfalls in teratology counselling

British Journal of Clinical Pharmacology, EarlyView.
Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley   +1 more source

A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse [PDF]

, 2017
The aims of the research were to establish whether diphenylhydantoin and phenobarbitone are teratogenic in mice both in vivo and in an in vitro whole embryo culture system, to investigate possible mechanisms of teratogenicity and to examine whether the ...
Beyers, Nulda
core   +1 more source

Prevalence of pregnancy and birth outcomes following biologic exposure in immune‐mediated inflammatory diseases: A population‐based study

British Journal of Clinical Pharmacology, EarlyView.
Aims Almost 5% of pregnancies are affected by immune‐mediated inflammatory diseases (IMIDs). As treatments become available, understanding their use during pregnancy is important. We aimed to describe maternal, pregnancy and infant outcomes among IMID pregnancies exposed to biologic therapies. Methods Using the Merative™ MarketScan® Commercial Database,
Leah K. Flatman, Lisiane F. Leal, Gabra Nohmie, Anick Bérard   +3 more
wiley   +1 more source

The placental transfer of nirmatrelvir using the ex vivo human placental perfusion model

British Journal of Clinical Pharmacology, EarlyView.
Aims Nirmatrelvir is an effective therapeutic option for COVID‐19 infection and is often administered after symptom onset in pregnant individuals, but few data are available on the associated fetal exposure. The placental perfusion model evaluates maternal–fetal drug transfer across the human placenta and thus can determine fetal drug exposure.
Magdalene Zabek, Eddie Chan, Yong Jin Lim, Bradley L. Urquhart, Facundo Garcia‐Bournissen, Janine R. Hutson   +5 more
wiley   +1 more source

Teratogenicity of Ochratoxin A and the Degradation Product, Ochratoxin α, in the Zebrafish (Danio rerio) Embryo Model of Vertebrate Development

Toxins, 2016
Ochratoxins, and particularly ochratoxin A (OTA), are toxic fungal-derived contaminants of food and other agricultural products. Growing evidence supports the degradation of OTA by chemical, enzymatic and/or microbial means as a potential approach to ...
Mehreen Haq, Nelson Gonzalez, Keenan Mintz, Asha Jaja-Chimedza, Christopher Lawrence De Jesus, Christina Lydon, Aaron Z. Welch, John P. Berry   +7 more
doaj   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Review of current and "omics" methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms [PDF]

, 2012
Ethnopharmacological relevance: The increasing use of traditional herbal medicines around the world requires more scientific evidence for their putative harmlessness. To this end, a plethora of methods exist, more or less satisfying.
Qu, Fan, Efferth, T, Baudoux, T., Efferth, Thomas, Pelkonen, O, Thomas Baudoux, Stévigny, Caroline, Zhou, Jue, Pierre Duez, Caroline Stévigny, Ouedraogo, Moustapha, Duez, Pierre, Baudoux, Thomas, Olavi Pelkonen, Chan, Kelvin, Jean-Marie Colet, Zhou, J, Joëlle Nortier, Qu, F., Kelvin Chan, Stévigny, C, Duez, P, Nortier, Joëlle, Ouedraogo, M, Thomas Efferth, Qu, F, Chan, K, Chan, Kelvin (R15157), Colet, Jean-Marie, Jue Zhou, Pelkonen, Olavi, Fan Qu, Zhou, J., Shaw, D, Nortier, J, Moustapha Ouedraogo, Shaw, Debbie, Baudoux, T, Efferth, T., Debbie Shaw   +39 more
core   +1 more source

In vitro teratogenicity testing using a 3D, embryo-like gastruloid system

, 2021
Pharmaceuticals intended for use in patients of childbearing potential need to be tested for teratogenicity before marketing. Several pharmaceutical companies use animal-free in vitro models which allow a more rapid selection of lead compounds and ...
Moris, Naomi, Mantziou, Veronika, Kustermann, Stefan, Jaklin, Manuela, Baillie-Benson, Peter, Martínez Arias, Alfonso, Arias, Alfonso Martínez, Manuela Jaklin, Alfonso Martínez Arias, Veronika Mantziou, Peter Baillie-Benson, Naomi Moris, Stefan Kustermann   +12 more
core   +1 more source

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population‐Based Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit, Daphna Idan, Ariel Avraham Hasidim, Tal Michael, Amalia Levy, Gali Pariente, Eitan Lunenfeld, Sharon Daniel   +7 more
wiley   +1 more source

Treatment for nausea and vomiting in pregnant women [PDF]

Farmacja Polska
Nausea and vomiting of pregnancy (NVP), associated as „morning sickness”, is a problem faced by approximately 70% of pregnant women. The exact mechanism of NVP is not known, research suggests that growth and differentiation factor 15 (GDF 15) secreted by
Józef Muszyński, Jakub Brzozowski, Katarzyna Dettlaff   +2 more
doaj   +1 more source