MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). [PDF]
, 2017 A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model.
Bouvet, Michael +10 more
core
Intestinal Atresia in Finland: Maternal Risk Factors, Prevalence, Associated Anomalies and Survival
Acta Paediatrica, EarlyView.ABSTRACT Aim We aimed to investigate prevalence, associated anomalies and survival of congenital intestinal atresia and to examine maternal risk factors for jejunoileal atresia (JIA). Methods All children born with, or pregnancies terminated because of, JIA or colonic atresia (CA) in Finland during 1987–2019 were identified from the Finnish Register of
Esko Tahkola +9 more
wiley +1 more source
Trichloroethylene: A Cardiac Teratogen in Developing Chick Embryos [PDF]
, 1988 Cleo P. Loeber +3 more
openalex +1 more source
Provider Perceptions of Perinatal Mental Healthcare Access
Birth, EarlyView.Study methodology and conclusions: Primary barriers to care and action items for providers. ABSTRACT Background The consequences of untreated perinatal mental health conditions are well‐established, yet fewer than one in five women experiencing perinatal mental health distress receive treatment. Although recommendations for evidence‐based treatment are
Susanna Sutherland +2 more
wiley +1 more source
Clinico-Radiologic Perspective of a Case of Hemifacial Microsomia [PDF]
Journal of Clinical and Diagnostic Research, 2016 Mandakini Subhash Mandale +3 more
doaj +1 more source
Molecular Landscape in Limb Anomalies: Diagnostic Yield and New Candidate Genes
Clinical Genetics, EarlyView.In 132 individuals with limb anomalies, diagnostic yield was 36% (47/132), including 25 novel variants, three cases with new phenotypes, and two candidate loci, HOXA11 and a small 2q31.1 deletion. Mouse data and exome‐wide analysis, key in identifying the candidate loci, represent an important opportunity for gene discovery.
Akram Mokhtari +7 more
wiley +1 more source
Effects of Multivitamins and Known Teratogens on Chick Cardiomyocytes Micromass Culture Assay [PDF]
Iranian Journal of Basic Medical Sciences, 2013 Objective(s): This study aimed to find out whether the chick cardiomyocyte micromass (MM) system could be employed to predict the teratogenecity of common environmental factors. Different multivitamins and over the counter drugs were used in this study.
Samreen Memon, Margaret Pratten
doaj
Program and Abstracts of a Special Symposium on Detection of Teratogens held at Montreal, Canada, August 21, 1977 [PDF]
, 1977 Marcus A. Klingberg +8 more
openalex +1 more source
Epilepsia, EarlyView.Abstract Lennox–Gastaut syndrome (LGS) is one of the most severe, yet one of the most discussed, childhood‐onset developmental and epileptic encephalopathies (DEEs). Dissent among epileptologists on the definition and minimum set of electroclinical features derives from the high etiological heterogeneity within the syndrome, which could make its ...
Antonella Riva +40 more
wiley +1 more source