Results 11 to 20 of about 17,298 (331)
Pregnancy and neonatal outcomes after periconceptional exposure to isotretinoin in Koreans [PDF]
Obstetrics & Gynecology Science, 2022 Objective Isotretinoin should not be used during pregnancy because of the risk of birth defects. Most pregnant women exposed to isotretinoin choose voluntary pregnancy termination due to concerns about birth defects.
Eun-Hwan Cha +9 more
doaj +1 more source
Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. [PDF]
, 2015 Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence.
Bouvet, Michael +8 more
core +13 more sources
Exposure to potentially teratogenic medications before and during the first trimester of pregnancy compared to women of childbearing age: A retrospective analysis of Swiss claims data (2015-2021). [PDF]
Acta Obstet Gynecol ScandIn Switzerland, most dispensed medications with teratogenic effect debated or proven were in the group of weak teratogenicity level. Reassuringly, many women discontinue treatment with potential teratogens before pregnancy. Abstract Introduction Exposure to potentially teratogenic medications during pregnancy is underinvestigated in Switzerland.
Marxer CA +5 more
europepmc +2 more sources
Genetic Susceptibility to Drug Teratogenicity: A Systematic Literature Review
Frontiers in Genetics, 2021 Since the 1960s, drugs have been known to cause teratogenic effects in humans. Such teratogenicity has been postulated to be influenced by genetics. The aim of this review was to provide an overview of the current knowledge on genetic susceptibility to ...
Julia do Amaral Gomes +22 more
doaj +1 more source
Viruses, 2021 Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in
Julia A. Gomes +11 more
doaj +1 more source
The Pathogenesis of Congenital Anomalies: Roles of Teratogens and Infections
Congenital Anomalies in Neonates - Clinical Perspectives [Working Title], 2020 Congenital anomalies present with significant financial, social, and moral issues and questions to the family and society and are difficult to rehabilitate.
M. Demirtaş
semanticscholar +1 more source
Frontiers in Genetics, 2021 The identification of thalidomide–Cereblon-induced SALL4 degradation has brought new understanding for thalidomide embryopathy (TE) differences across species. Some questions, however, regarding species variability, still remain.
Thayne Woycinck Kowalski +29 more
doaj +1 more source
Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies
Frontiers in Pharmacology, 2023 Background: Exposure in utero to certain medications can disrupt processes of fetal development, including brain development, leading to a continuum of neurodevelopmental difficulties.
R. L. Bromley +31 more
doaj +1 more source
F1000Research, 2016 Background: Acute high dose exposure to teratogenic chemicals alters the proper development of an embryo leading to infertility, impaired fecundity, and few viable offspring.
Alexis Killeen +1 more
doaj +1 more source