Comparative analysis of teratogen-induced malformations and gene expression across zebrafish strains in early development [PDF]
Toxicology ReportsZebrafish embryos are widely used in developmental toxicity testing. However, the extent to which genetic background influences susceptibility to teratogenic compounds remains incompletely understood.
Chitose Taya +6 more
doaj +3 more sources
Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells [PDF]
Cell Death Discovery, 2023 Summary Animal studies for embryotoxicity evaluation of potential therapeutics and environmental factors are complex, costly, and time-consuming. Often, studies are not of human relevance because of species differences.
Anna Cherianidou +11 more
doaj +2 more sources
Exposure to potentially teratogenic medications before and during the first trimester of pregnancy compared to women of childbearing age: A retrospective analysis of Swiss claims data (2015–2021) [PDF]
Acta Obstetricia et Gynecologica ScandinavicaIntroduction Exposure to potentially teratogenic medications during pregnancy is underinvestigated in Switzerland. We aimed to assess exposure to potential teratogens preconceptionally, during the first trimester, and in women of childbearing age, and ...
Carole A. Marxer +5 more
doaj +2 more sources
Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment [PDF]
Frontiers in ToxicologyIntroductionExposure to teratogenic compounds during pregnancy can lead to significant birth defects. Given the considerable variation in drug responses across species, along with the financial and ethical challenges associated with animal testing, the ...
José M. Horcas-Nieto +11 more
doaj +2 more sources
In Vitro Micropatterned Human Pluripotent Stem Cell Test (µP-hPST) for Morphometric-Based Teratogen Screening [PDF]
Scientific Reports, 2017 Exposure to teratogenic chemicals during pregnancy may cause severe birth defects. Due to high inter-species variation of drug responses as well as financial and ethical burdens, despite the widely use of in vivo animal tests, it’s crucial to develop ...
Jiangwa Xing +5 more
doaj +2 more sources
Experiences of sexual and reproductive health screening and counseling in the clinical setting among adolescents and young adults with rheumatic disease [PDF]
Pediatric Rheumatology Online JournalBackground Our objective was to describe differences among adolescents and young adults (AYAs) with rheumatic disease using teratogens compared to non-users in receipt of sexual and reproductive health (SRH) counseling, teratogenicity knowledge ...
Brittany Huynh +2 more
doaj +2 more sources
A Scoping Review of Human Teratogens and Their Impact on the Developing Brain: A Contribution From the ConcePTION Project. [PDF]
Birth Defects ResBluett-Duncan M +14 more
europepmc +2 more sources
Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. [PDF]
, 2015 Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence.
Bouvet, Michael +8 more
core +20 more sources
Viruses, 2021 Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in
Julia A. Gomes +11 more
doaj +1 more source
A standardized human embryoid body platform for the detection and analysis of teratogens. [PDF]
PLoS ONE, 2017 Teratogens are compounds that can induce birth defects upon exposure of the developing fetus. To date, most teratogen studies utilize pregnant rodents to determine compound teratogenicity in vivo.
Anthony Flamier +2 more
doaj +1 more source