Results 41 to 50 of about 2,627 (175)

SEPTIN12 Genetic Variants Confer Susceptibility to Teratozoospermia

PLoS ONE, 2012
It is estimated that 10-15% of couples are infertile and male factors account for about half of these cases. With the advent of intracytoplasmic sperm injection (ICSI), many infertile men have been able to father offspring. However, teratozoospermia still remains a big challenge to tackle. Septins belong to a family of cytoskeletal proteins with GTPase
Ying-Hung Lin, Ya-Yun Wang, Hau-Inh Chen, Yung-Che Kuo, Yu-Wei Chiou, Hsi-Hui Lin, Ching-Ming Wu, Chao-Chin Hsu, Han-Sun Chiang, Pao-Lin Kuo   +9 more
openaire   +4 more sources

Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity

Reproductive Medicine and Biology, 2023
Purpose Microscopic testicular sperm extraction is the most effective treatment for NOA, but the sperm retrieval rate is low and depends on testicular maturity. However, there are limited useful tests to assess testicular maturity.
Sohei Kuribayashi, Shinichiro Fukuhara, Go Tsujimura, Takahiro Imanaka, Koichi Okada, Norichika Ueda, Kentaro Takezawa, Hiroshi Kiuchi, Shigeyoshi Saito, Yusuke Takahashi, Hidetaka Kioka, Seiya Oura, Keisuke Shimada, Masahito Ikawa, Norio Nonomura   +14 more
doaj   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Impact of isolated teratozoospermia on the outcome of intrauterine insemination

Fertility and Sterility, 2005
One thousand six hundred forty-one IUI cycles performed in 615 couples were categorized, depending on the semen analysis of the male partner, in three groups of: normozoospermia, teratozoospermia, and male factor infertility. Clinical pregnancies and live births per cycle were significantly decreased in the teratozoospermia group when compared to the ...
Grigoriou, O, Pantos, K, Makrakis, E, Hassiakos, D, Konidaris, S, Creatsas, G   +5 more
openaire   +3 more sources

Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice

Andrology, Volume 14, Issue 6, Page 1636-1646, September 2026.
ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda, Haruhiko Miyata, Masahito Ikawa   +2 more
wiley   +1 more source

Semen Quality in Transgender Individuals Seeking Fertility Preservation

Andrology, Volume 14, Issue 6, Page 1771-1776, September 2026.
ABSTRACT Background Transgender individuals assigned male at birth (AMAB) may choose to preserve their fertility prior to starting gender‐affirming hormone therapy (GAHT). However, limited data exist regarding the baseline reproductive and hormonal characteristics of this population before and after GAHT.
Maurizio De Rocco Ponce, Eden Troka, Massimiliano Raffo, Luis Miguel Malca Caballero, Alberto Ferlin, Andrea Salonia, Eduard Ruiz Castañé, Alberto Scala, Andrea Garolla, the Gender Incongruence Interdisciplinary Group (GIIG), Andrea Garolla, Anna Aprile, Camillo Barbisan, Anna Belloni Fortina, Valentina Camozzi, Elena Campello, Annamaria Cattelan, Chiara Ceolin, Fabrizio Dal Moro, Giorgio De Conti, Angela Favaro, Alberto Ferlin, Francesco Francini Pesenti, Michela Gatta, Marta Ghisi, Sandro Giannini, Laura Guazzarotti, Massimo Iafrate, Paolo Meneguzzo, Marina Miscioscia, Giulia Musso, Giancarlo Ottaviano, Corrado Marchese Ragona, Carlo Saccardi, Lolita Sasset, Rossana Schiavo, Giuseppe Sergi, Paolo Simioni, Benedetta Tascini, Eleonora Vania, Elisa Varotto, Francesca Venturini, Tommaso Vezzaro, Fabrizio Vianello   +43 more
wiley   +1 more source

Lack of testicular seipin causes teratozoospermia syndrome in men [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The relationship between body fat and male reproduction is clearly seen when excess fat compromises fertility; however, potential consequences of adipose tissue paucity on fertility are unclear. We report that lack of seipin, a transmembrane protein localizing to the endoplasmic reticulum, causes both paucity of adipose ...
Min, Jiang, Mingming, Gao, Chaoming, Wu, Hui, He, Xuejiang, Guo, Zuomin, Zhou, Hongyuan, Yang, Xinhua, Xiao, George, Liu, Jiahao, Sha   +9 more
openaire   +2 more sources

A Novel Hemizygous CDX4 Missense Variant Identified in a Taiwanese Man with Severe Teratozoospermia

Medicina
Background and Objectives: Male factors account for approximately 30–50% of subfertile couples. Teratozoospermia is one of the major causes of male infertility; however, the genetic factors underlying many cases remain incompletely understood. This study
Chin-Fong Au, Ya-Yun Wang, Tsung-Hsuan Lai, Chying-Chyuan Chan, Chih-Chun Ke, Shiu-Dong Chung, Ying-Hung Lin   +6 more
doaj   +1 more source

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology, Volume 14, Issue 5, Page 1272-1281, July 2026.
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto, Carlotta Pozza, Gaia Cicolani, Anna Chiara Conflitti, Luisa Caponecchia, Serena Bianchini, Enrico Delli Paoli, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori, Francesco Lombardo, Francesco Pallotti, Donatella Paoli   +12 more
wiley   +1 more source

Teratozoospermia influences fertilization rate in vitro but not embryo quality [PDF]

Human Reproduction, 1997
The purpose of this study was to retrospectively compare the overall results and embryo quality in 102 cycles of in-vitro fertilization (IVF)-embryo transfer using normal frozen donor semen (group D) and 94 cycles of IVF-embryo transfer using husbands' teratozoospermic sperm (group T). Donor semen was purchased from men with proven fertility and normal
P, Terriou, C, Giorgetti, P, Auquier, E, Hans, J L, Spach, J, Salzmann, R, Roulier   +6 more
openaire   +2 more sources