Results 51 to 60 of about 4,887 (219)

Chromosomal disorders and male infertility [PDF]

, 2015
Male factor infertility is considered a complex disorder with a largely unknown etiology that affects about 7% of men. In general, genetic abnormalities account for 15%-30% of condition and Y chromosome microdeletions are also frequent.
Alves, C., Ambrósio, P., Brito, F., Caetano, I., Correia, H., Geraldes, M.C., Gonçalves, J., Marques, B., Pedro, S., Serafim, S., Silva, M., Simão, L.   +11 more
core  

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

The Effect of Teratozoospermia on Sex Chromosomes in Human Embryos

The Application of Clinical Genetics, 2021
The aim of this study is to evaluate the effect of abnormal semen morphology on the frequency of sex chromosomal abnormalities in embryos obtained by ICSI, which represents the first to be studied in Egyptian population.Forty-two couples suffering from male infertility due to teratozoospermia were divided into two groups: patients with severe and ...
Dalia Mostafa Nayel, Hanan Salah El Din Mahrous, Emad El Din Khalifa, Soha Kholeif, Ghada Mohamed Elhady   +4 more
openaire   +5 more sources

High‐Resolution Imaging Reveals Mitochondrial Protein Imbalance in Sperm of Oligoasthenospermic Men

Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.
ABSTRACT Male infertility accounts for nearly half of global infertility cases and is often linked to poor sperm quality, such as oligospermia, asthenospermia, and teratospermia. Although the exact mechanisms remain unclear, mitochondria, which are critical for ATP production and reactive oxygen species generation during fertilization, are increasingly
Pauline Teixeira, Magalie Boguenet, Florence Pascaretti‐Grizon, Florence Manero, Solenn Plouzennec, Pierre‐Emmanuel Bouet, Pascal Reynier, Arnaud Chevrollier, Pascale May‐Panloup   +8 more
wiley   +1 more source

European Academy of Andrology guideline Management of oligo‐astheno‐teratozoospermia [PDF]

Andrology, 2018
SummaryBackgroundOligo‐astheno‐teratozoospermia is frequently reported in men from infertile couples. Its etiology remains, in the majority of cases, unknown with a variety of factors to contribute to its pathogenesis. The aim of this European Academy of Andrology guideline was to provide an overview of these factors and to discuss available management
Colpi, G. M., Francavilla, S., Haidl, G., Link, K., Behre, H. M., Goulis, D. G., Krausz, C., Giwercman, A.   +7 more
openaire   +2 more sources

Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity

Reproductive Medicine and Biology, 2023
Purpose Microscopic testicular sperm extraction is the most effective treatment for NOA, but the sperm retrieval rate is low and depends on testicular maturity. However, there are limited useful tests to assess testicular maturity.
Sohei Kuribayashi, Shinichiro Fukuhara, Go Tsujimura, Takahiro Imanaka, Koichi Okada, Norichika Ueda, Kentaro Takezawa, Hiroshi Kiuchi, Shigeyoshi Saito, Yusuke Takahashi, Hidetaka Kioka, Seiya Oura, Keisuke Shimada, Masahito Ikawa, Norio Nonomura   +14 more
doaj   +1 more source

Meiotic recombination and male infertility: from basic science to clinical reality? [PDF]

, 2011
Infertility is a common problem that affects approximately 15% of the population. Although many advances have been made in the treatment of infertility, the molecular and genetic causes of male infertility remain largely elusive. This review will present
Hann, Michael C., Lau, Patricio E., Tempest, Helen G.   +2 more
core   +1 more source

Pharmacogenetics of follicle‐stimulating hormone action in the male

Andrology, Volume 14, Issue 4, Page 1064-1072, May 2026.
Abstract Male factor infertility (MFI) is involved in half of the cases of couple infertility. The follicle‐stimulating hormone (FSH) therapy is considered efficient to improve semen parameters and pregnancy rate in patients with idiopathic MFI, following the lesson learned from hypogonadotropic hypogonadism.
Andrea Graziani, Giuseppe Grande, Raffele Scafa, Riccardo Selice, Andrea Garolla, Maria Santa Rocca, Cinzia Vinanzi, Alberto Ferlin   +7 more
wiley   +1 more source

An Autosomal Translocation 73,XY,t(12;20)(q11;q11) in an Infertile Male Llama (Lama glama) With Teratozoospermia

Frontiers in Genetics, 2019
Structural chromosome abnormalities, such as translocations and inversions occasionally occur in all livestock species and are typically associated with reproductive and developmental disorders.
Malorie P. Baily, Felipe Avila, Pranab J. Das, Michelle A. Kutzler, Terje Raudsepp   +4 more
doaj   +1 more source

Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis [PDF]

, 2015
This work was supported by a Merit Scholarship from the Islamic Development Bank (to M.M.U.T.), The Agency for Science, Technology and Research, Singapore (A*STAR) (M.F.M.S), the Medical Research Council (MRC) [NIRG GO800203 and Research Grant MR/L002620/
Edwardson, J Michael, O'Rahilly, Stephen, Rochford, Justin J, Sim, M F Michelle, Talukder, Md. Mesbah Uddin   +4 more
core   +2 more sources