Results 51 to 60 of about 5,472 (197)

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan, Gnanadoss, John Joel, Sundaramurthi, Jagadish Chandrabose, Velmurugan, Devadasan, Vincent, Savariar   +4 more
core   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

The course of type 1 hepato-renal syndrome post liver transplantation [PDF]

, 2005
Background. Hepato-renal syndrome (HRS) is a functional form of renal failure that occurs in patients with end-stage liver disease. Previously considered fatal without liver transplantation, treatment with vasoconstrictors and albumin has been ...
Marik, PE, Starzl, TE, Wood, K
core   +1 more source

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

Antiparallel β‐Sheet as a Key Motif of Amyloid‐β Inhibitor Designed via Topological Peptide Reprogramming

Angewandte Chemie, Volume 137, Issue 28, July 7, 2025.
Targeting Amyloid‐β (Aβ) aggregation requires a peptide‐based approach that accounts for the structural heterogeneity of Aβ. Here, we employ topological reprogramming via disulfide bonds to stabilize antiparallel β‐sheets within the dimeric peptide.
Dongjoon Im, Ye Eun Lee, Gyusub Yoon, William A. Goddard III, Tae Su Choi, Hugh I. Kim   +5 more
wiley   +2 more sources

Terlipressin‐induced skin necrosis in cirrhotic patients—A case report and comprehensive literature review

Clinical Case Reports
Key Clinical Message The occurrence of terlipressin‐induced skin necrosis in cirrhotic patients is a rare but serious adverse event that warrants further investigation.
Ashraf I. Ahmed, Muhammad Zain Kaleem, Shahem Abbarh, Haider Hussein Barjas, Abdellatif Ismail, Mhd Kutaiba Albuni, Bisher Sawaf   +6 more
doaj   +1 more source

Cutaneous Ischaemia Following Terlipressin Therapy for Hepatorenal Syndrome [PDF]

Journal of Clinical and Diagnostic Research, 2018
Hepatorenal Syndrome (HRS) is a potentially fatal complication of hepatic failure and portal hypertension. Among the various treatments available including octreotide, midodrine and albumin, the current standard of care for stable patients is ...
Aneesh Basheer, Dayanandan Yoganandan, Meera Baby John, Prem Kumar Guna   +3 more
doaj   +1 more source

Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe hepatic encephalopathy [PDF]

, 2004
There is increasing evidence that terlipressin is useful in patients with cirrhosis and hepatorenal syndrome, but there are no data of its use in patients with acute liver failure (ALF) in whom hepatorenal syndrome is common.
Davies, N.A., Hayes, P.C., Jalan, R., Lee, A., Mookerjee, R.P., Shawcross, D.L., Williams, R.   +6 more
core  

Plasma Adsorption Perfusion (BR‐350) Versus Open Albumin Dialysis (OPAL) for Hyperbilirubinemia in Hepatic Failure in Cirrhotic Patients

Artificial Organs, Volume 50, Issue 4, Page 610-624, April 2026.
The therapy with PAP using BR‐350 resulted in a significant decrease of bilirubin concentrations. The median relative reduction of bilirubin was comparable between PAP and OPAL (47% vs. 40%, p = 0.29). The crossover comparison between the single session of PAP using BR‐350 and OPAL revealed similar relative reduction rates of bilirubin.
Justa Friebus‐Kardash, Alica Ochs, Amina Louzi, Andreas Kribben, Bartosz Tyczynski, Jassin Rashidi‐Alavijeh, Andreas Schütte, Hartmut H. Schmidt, Amos Zeller   +8 more
wiley   +1 more source

Intraoperative Use of Vasoactive Agents in Non‐Cardiac Surgery: Protocol for a Post Hoc Cohort Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 2, February 2026.
ABSTRACT Background Intraoperative hypotension is a well‐known clinical condition and often treated with vasoactive agents. Previous cohort studies have indicated that large numbers of patients receive this treatment, but they have been limited to specific surgical populations or single agents.
Emilie Stokholm Bækgaard, Morten Vester‐Andersen, Anders Granholm, Morten Hylander Møller, Ben Creagh‐Brown, Ib Jammer, Mette Krag   +6 more
wiley   +1 more source