Results 121 to 130 of about 2,469 (172)
New Methods of Analysis and Investigation of Terpenoid Indole Alkaloids
Advances in Botanical Research, 2013 Abstract Terpenoid indole alkaloids are biologically active compounds that have been used as pharmaceuticals among others as anticancer, antimalarial, antihypertensive and hypoglycemic agents for more than 40 years. Many efforts have been focused on their extraction, isolation, separation and structural elucidation by means of different approaches ...
Robert Verpoorte, Young Hae Choi
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Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids
Organic & Biomolecular Chemistry, 2022Aspidosperma terpenoid alkaloids can be quickly prepared using semisynthesis from naturally sourced tabersonine, featuring multiple oxygen-based substituents on the indole ring such as hydroxy and methoxy groups for cancer-targeted SAR studies.
Jinfeng Kang +4 more
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Terpenoid indole alkaloids from Mappianthus iodoides Hand.-Mazz.
Phytochemistry, 2014Ten terpenoid indole alkaloids, mappiodines A-C and mappiodosides A-G, together with eight known compounds, were isolated from stems of Mappianthus iodoides Hand.-Mazz. Their structures were elucidated by spectroscopic analyses including 1D, 2D NMR, MS and CD methods. The ten compounds were evaluated for their cytotoxic activity, but were inactive.
Li Jun
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Biosynthesis of the teleocidin-type terpenoid indole alkaloids
Organic & Biomolecular Chemistry, 2018Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.
Takayoshi Awakawa, Ikuro Abe
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Indole alkaloids and terpenoids fromTabernaemontana markgrafiana
Phytochemistry, 1994Abstract The bark of Tabernaemontana markgrafiana yielded five acetylated pentacyclic triterpenes and 24 monoterpene indole alkaloids.
Nielsen, Helene Bendstrup +4 more
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Terpenoid indole alkaloid profile changes in Catharanthus pusillus during development
Plant Science, 2001The terpenoid indole alkaloid content of Catharanthus pusillus was investigated during development from young to old plants. Different plant organs were assessed showing that the new leaves were the main repository site with vindoline ( approximately 4.8 mg/g DW) and catharanthine ( approximately 2.2 mg/g DW) being the major metabolites with the ...
Robert Verpoorte +2 more
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Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus
Frontiers of Medicine, 2014Catharanthus roseus is one of the most extensively investigated medicinal plants, which can produce more than 130 alkaloids, including the powerful antitumor drugs vinblastine and vincristine. Here we review the recent advances in the biosynthetic pathway of terpenoid indole alkaloids (TIAs) in C.
Xiaoxuan, Zhu +3 more
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Why are the terpenoid indole alkaloids of type I homochiral?
Chirality, 2001AbstractIn the presence of the enzyme strictosidine synthase, the coupling reaction of secologanin and tryptamine is completely stereoselective and affords strictosidine with 3S configuration, exclusively. The stereoselectivity is transferred and retained in most indole alkaloids of type I in which C‐3 is not involved in subsequent reactions.
G, Beke +3 more
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Chinese Journal of Natural Medicines, 2021
Terpenoid indole (TIAs) and β-carboline alkaloids (BCAs), such as suppressant reserpine, vasodilatory yohimbine, and antimalarial quinine, are natural compounds derived from strictosidine. These compounds can exert powerful pharmacological effects but be obtained from limited source in nature. the whole biosynthetic pathway of TIAs and BCAs, The Pictet-
Chang Hong Wang
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Terpenoid indole (TIAs) and β-carboline alkaloids (BCAs), such as suppressant reserpine, vasodilatory yohimbine, and antimalarial quinine, are natural compounds derived from strictosidine. These compounds can exert powerful pharmacological effects but be obtained from limited source in nature. the whole biosynthetic pathway of TIAs and BCAs, The Pictet-
Chang Hong Wang
exaly +3 more sources
Planta Medica, 1996
An isocratic HPLC system is described which allows the separation of the iridoid and indole precursors of terpenoid indole alkaloids, which are present in a single crude extract. The system consists of a column of LiChrospher 60 RP select B 5 microm, 250 x 4 mm (Merck) with an eluent of 1% formic acid-acetonitrile-trichloroacetic acid (100:10:0.25, v:v:
D, Dagnino, J, Schripsema, R, Verpoorte
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An isocratic HPLC system is described which allows the separation of the iridoid and indole precursors of terpenoid indole alkaloids, which are present in a single crude extract. The system consists of a column of LiChrospher 60 RP select B 5 microm, 250 x 4 mm (Merck) with an eluent of 1% formic acid-acetonitrile-trichloroacetic acid (100:10:0.25, v:v:
D, Dagnino, J, Schripsema, R, Verpoorte
openaire +2 more sources