Results 131 to 140 of about 2,466 (171)

Biotransformation of tryptamine and secologanin into plant terpenoid indole alkaloids by transgenic yeast

Applied Microbiology and Biotechnology, 2001
A transgenic Saccharomyces cerevisiae was constructed containing the cDNAs coding for strictosidine synthase (STR) and strictosidine beta-glucosidase (SGD) from the medicinal plant Catharanthus roseus. Both enzymes are involved in the biosynthesis of terpenoid indole alkaloids. The yeast culture was found to express high levels of both enzymes.
A, Geerlings, F J, Redondo, A, Contin, J, Memelink, R, van der Heijden, R, Verpoorte   +5 more
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Three New Terpenoid Indole Alkaloids fromCatharanthus roseus

Planta Medica, 2010
Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (4-10), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR).
Lei, Wang, Yu, Zhang, Hong-Ping, He, Qiang, Zhang, Shi-Fei, Li, Xiao-Jiang, Hao   +5 more
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Advance in biosynthesis of terpenoid indole alkaloids and its regulation in Catharanthus roseus

China Journal of Chinese Materia Medica, 2016
Catharanthus roseus can produce a variety of terpenoid indole alkaloids (TIA), most of which exhibit strong pharmacological activities. Hence, biosynthesis and regulation of TIA have received recent attention. 3α (S)-strictosidine is an important node in TIA biosynthesis, which is a condensation product of secologanin and tryptamine.
Xue-Jun, Kuang, Cai-Xia, Wang, Li-Qiu, Zou, Xiao-Xuan, Zhu, Chao, Sun   +4 more
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Terpenoid Indole Alkaloids from Winchia calophylla

Journal of Natural Products, 2005
Three new indole alkaloids, N(4)-demethyl-12-methoxyalstogustine (1), 17-carboxyl-N(4)-methylechitamidine chloride (2), and 17-carboxyl-12-methoxy-N(4)-methylechitamidine chloride (3), along with 15 known alkaloids, were isolated from the ethanolic extract of the stem bark of Winchia calophylla.
Li-She, Gan, Sheng-Ping, Yang, Yan, Wu, Jian, Ding, Jian-Min, Yue   +4 more
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Alkaloids Derived from Tryptophan: Terpenoid Indole Alkaloids

2013
L-Tryptophan is an indole ring containing aromatic amino acid derived via the shikimate pathway. The tryptophan-derived alkaloids are found in eight families, of which, Apocynaceae, Loganiaceae, Rubiaceae, and Nyssaceae are the best sources. The alkaloids under discussion are theCatharanthus alkaloids, namely, ajmalicine, tabersonine, catharanthine ...
Shilpa Ramani, Nandadevi Patil, Suhas Nimbalkar, Chelliah Jayabaskaran   +3 more
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Identification and Characterization of Transcription Factors Regulating Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

2022
Biosynthesis of the therapeutically valuable terpenoid indole alkaloids (TIAs), in the medicinal plant Catharanthus roseus, is one of the most elaborate and complex metabolic processes. Although genomic and transcriptomic resources have significantly accelerated gene discovery in the TIA pathway, relatively few genes of transcription factors (TFs) have
Sanjay K, Singh, Barunava, Patra, Joshua J, Singleton, Yongliang, Liu, Priyanka, Paul, Xueyi, Sui, Nitima, Suttipanta, Sitakanta, Pattanaik, Ling, Yuan   +8 more
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Microbial allies: exploring fungal endophytes for biosynthesis of terpenoid indole alkaloids

Archives of Microbiology
Terpenoid indole alkaloids (TIAs) are natural compounds found in medicinal plants that exhibit various therapeutic activities, such as antimicrobial, anti-inflammatory, antioxidant, anti-diabetic, anti-helminthic, and anti-tumor properties. However, the production of these alkaloids in plants is limited, and there is a high demand for them due to the ...
Jaya Prabha, Khalkho, Abhishek, Beck, , Priyanka, Banishree, Panda, Ramesh, Chandra   +4 more
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Terpenoid indole alkaloid biotransformation capacity of suspension cultures of Tabernaemontana divaricata

Phytochemistry, 1994
Abstract Two cell lines of Tabernaemontana divaricata derived from the same suspension culture were compared with respect to their biotransformation capacity. One is a high indole alkaloid-producing culture which accumulated mainly O-acetylvallesamine. The other cell line biosynthesizes terpenoid indole alkaloids in much lower amounts.
Denise Dagnino, Jan Schripsema, Robert Verpoorte   +2 more
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Alkaloids of Terpenoid Origin (excepting indole alkaloids and ergot alkaloids)

1998
A large number of alkaloids are based on terpenoid structures. In most instances, the source of the nitrogen is not established, but the remaining portions of the molecule typically arise via the pathways leading to the various groups of terpenes.
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Metabolic engineering of terpenoid indole alkaloid pathway in Catharanthus roseus

Planta Medica, 2013
Eukaryotes such as higher plants have evolved to produce a diverse range of low-molecular-weight secondary compounds that can be used as food and feed additives, flavours, fragrances, cosmetics, agrochemicals and pharmaceuticals. The dominant role of secondary metabolites in the pharmaceutical industry is demonstrated by the fact that approximately 50%
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