Results 131 to 140 of about 2,469 (172)
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Advances in Biochemical Engineering/Biotechnology, 2013
This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, including genetic engineering and metabolic profiling, was conducted based on the gained knowledge.
Jacqueline Shanks
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This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, including genetic engineering and metabolic profiling, was conducted based on the gained knowledge.
Jacqueline Shanks
exaly +3 more sources
Alkaloids Derived from Tryptophan: Terpenoid Indole Alkaloids
2013L-Tryptophan is an indole ring containing aromatic amino acid derived via the shikimate pathway. The tryptophan-derived alkaloids are found in eight families, of which, Apocynaceae, Loganiaceae, Rubiaceae, and Nyssaceae are the best sources. The alkaloids under discussion are theCatharanthus alkaloids, namely, ajmalicine, tabersonine, catharanthine ...
Shilpa Ramani +3 more
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Applied Microbiology and Biotechnology, 2001
A transgenic Saccharomyces cerevisiae was constructed containing the cDNAs coding for strictosidine synthase (STR) and strictosidine beta-glucosidase (SGD) from the medicinal plant Catharanthus roseus. Both enzymes are involved in the biosynthesis of terpenoid indole alkaloids. The yeast culture was found to express high levels of both enzymes.
A, Geerlings +5 more
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A transgenic Saccharomyces cerevisiae was constructed containing the cDNAs coding for strictosidine synthase (STR) and strictosidine beta-glucosidase (SGD) from the medicinal plant Catharanthus roseus. Both enzymes are involved in the biosynthesis of terpenoid indole alkaloids. The yeast culture was found to express high levels of both enzymes.
A, Geerlings +5 more
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Three New Terpenoid Indole Alkaloids fromCatharanthus roseus
Planta Medica, 2010Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (4-10), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR).
Lei, Wang +5 more
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Advance in biosynthesis of terpenoid indole alkaloids and its regulation in Catharanthus roseus
China Journal of Chinese Materia Medica, 2016Catharanthus roseus can produce a variety of terpenoid indole alkaloids (TIA), most of which exhibit strong pharmacological activities. Hence, biosynthesis and regulation of TIA have received recent attention. 3α (S)-strictosidine is an important node in TIA biosynthesis, which is a condensation product of secologanin and tryptamine.
Xue-Jun, Kuang +4 more
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Plant Science, 2020
Transcription factor (TF) gene clusters in plants, such as tomato, potato, petunia, tobacco, and almond, have been characterized for their roles in the biosynthesis of diverse array of specialized metabolites. In Catharanthus roseus, three AP2/ERF TFs, ORCA3, ORCA4, and ORCA5, have been shown to be present on the same genomic scaffold, forming a ...
Sitakanta Pattanaik +2 more
exaly +3 more sources
Transcription factor (TF) gene clusters in plants, such as tomato, potato, petunia, tobacco, and almond, have been characterized for their roles in the biosynthesis of diverse array of specialized metabolites. In Catharanthus roseus, three AP2/ERF TFs, ORCA3, ORCA4, and ORCA5, have been shown to be present on the same genomic scaffold, forming a ...
Sitakanta Pattanaik +2 more
exaly +3 more sources
Terpenoid Indole Alkaloids from Winchia calophylla
Journal of Natural Products, 2005Three new indole alkaloids, N(4)-demethyl-12-methoxyalstogustine (1), 17-carboxyl-N(4)-methylechitamidine chloride (2), and 17-carboxyl-12-methoxy-N(4)-methylechitamidine chloride (3), along with 15 known alkaloids, were isolated from the ethanolic extract of the stem bark of Winchia calophylla.
Li-She, Gan +4 more
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2022
Biosynthesis of the therapeutically valuable terpenoid indole alkaloids (TIAs), in the medicinal plant Catharanthus roseus, is one of the most elaborate and complex metabolic processes. Although genomic and transcriptomic resources have significantly accelerated gene discovery in the TIA pathway, relatively few genes of transcription factors (TFs) have
Sanjay K, Singh +8 more
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Biosynthesis of the therapeutically valuable terpenoid indole alkaloids (TIAs), in the medicinal plant Catharanthus roseus, is one of the most elaborate and complex metabolic processes. Although genomic and transcriptomic resources have significantly accelerated gene discovery in the TIA pathway, relatively few genes of transcription factors (TFs) have
Sanjay K, Singh +8 more
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Bioproduction of Terpenoid Indole Alkaloids from Catharanthus roseus Cell Cultures
2013Pedreño Maria A +2 more
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Alkaloids of Terpenoid Origin (excepting indole alkaloids and ergot alkaloids)
1998A large number of alkaloids are based on terpenoid structures. In most instances, the source of the nitrogen is not established, but the remaining portions of the molecule typically arise via the pathways leading to the various groups of terpenes.
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