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Microbial allies: exploring fungal endophytes for biosynthesis of terpenoid indole alkaloids
Archives of MicrobiologyTerpenoid indole alkaloids (TIAs) are natural compounds found in medicinal plants that exhibit various therapeutic activities, such as antimicrobial, anti-inflammatory, antioxidant, anti-diabetic, anti-helminthic, and anti-tumor properties. However, the production of these alkaloids in plants is limited, and there is a high demand for them due to the ...
Jaya Prabha, Khalkho +4 more
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Phytochemistry, 1994
Abstract Two cell lines of Tabernaemontana divaricata derived from the same suspension culture were compared with respect to their biotransformation capacity. One is a high indole alkaloid-producing culture which accumulated mainly O-acetylvallesamine. The other cell line biosynthesizes terpenoid indole alkaloids in much lower amounts.
Denise Dagnino +2 more
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Abstract Two cell lines of Tabernaemontana divaricata derived from the same suspension culture were compared with respect to their biotransformation capacity. One is a high indole alkaloid-producing culture which accumulated mainly O-acetylvallesamine. The other cell line biosynthesizes terpenoid indole alkaloids in much lower amounts.
Denise Dagnino +2 more
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Metabolic engineering of terpenoid indole alkaloid pathway in Catharanthus roseus
Planta Medica, 2013Eukaryotes such as higher plants have evolved to produce a diverse range of low-molecular-weight secondary compounds that can be used as food and feed additives, flavours, fragrances, cosmetics, agrochemicals and pharmaceuticals. The dominant role of secondary metabolites in the pharmaceutical industry is demonstrated by the fact that approximately 50%
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Plant Cell Reports, 2015
Transgenic hairy roots of R. stricta were developed for investigation of alkaloid accumulations. The contents of five identified alkaloids, including serpentine as a new compound, increased compared to non-transformed roots. Rhazya stricta Decne. is a rich source of pharmacologically active terpenoid indole alkaloids (TIAs).
Akhgari, Amir +5 more
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Transgenic hairy roots of R. stricta were developed for investigation of alkaloid accumulations. The contents of five identified alkaloids, including serpentine as a new compound, increased compared to non-transformed roots. Rhazya stricta Decne. is a rich source of pharmacologically active terpenoid indole alkaloids (TIAs).
Akhgari, Amir +5 more
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Plant Cell Reports, 1993
Two cell lines of Tabernaemontana divaricata derived from the same suspension culture accumulate different amounts of the terpenoid indole alkaloids O-acetylvallesamine and voaphylline. [(15)N]O-acetylvallesamine and [(15)N]voaphylline were added to the suspension cultures to investigate whether the lack of accumulating capacity of one of the cell ...
D, Dagnino, J, Schripsema, R, Verpoorte
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Two cell lines of Tabernaemontana divaricata derived from the same suspension culture accumulate different amounts of the terpenoid indole alkaloids O-acetylvallesamine and voaphylline. [(15)N]O-acetylvallesamine and [(15)N]voaphylline were added to the suspension cultures to investigate whether the lack of accumulating capacity of one of the cell ...
D, Dagnino, J, Schripsema, R, Verpoorte
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Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC‐MS
Phytochemical Analysis, 2015AbstractIntroductionRhazya stricta Decne. (Apocynaceae) is a medicinal plant rich in terpenoid indole alkaloids (TIAs), some of which possess important pharmacological properties. The study material including transgenic hairy root cultures have been developed and their potential for alkaloid production are being investigated.ObjectiveIn this study, a ...
Akhgari, Amir +7 more
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Terpenoid Indole Alkaloids Biosynthesis and Metabolic Engineering in Catharanthus roseus
Journal of Integrative Plant Biology, 2007Abstract Catharanthus roseus L. (Madagascar periwinkle) biosynthesizes a diverse array of secondary metabolites including anticancer dimeric alkaloids (vinblastine and vincristine) and antihypertensive alkaloids (ajmalicine and serpentine). The multi‐step terpenoid indole alkaloids (TIAs) biosynthetic pathway in C. roseus is complex and is
Dong‐Hui Liu +6 more
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Secondary Metabolism in Cell Cultures of Some Terpenoid-Indole Alkaloid Producing Plants
1988In the past years it has been proven that large scale culturing of plant cells is feasible. The production of shikonin (1) and of ginseng biomass (2) are examples of a commercial scale production with plant cell cultures.
R. Verpoorte +8 more
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Terpenoid indole alkaloids, a secondary metabolite in plant defense response
2021M. Thippeswamy +3 more
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