Results 141 to 150 of about 134,369 (196)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC‐MS

Phytochemical Analysis, 2015
AbstractIntroductionRhazya stricta Decne. (Apocynaceae) is a medicinal plant rich in terpenoid indole alkaloids (TIAs), some of which possess important pharmacological properties. The study material including transgenic hairy root cultures have been developed and their potential for alkaloid production are being investigated.ObjectiveIn this study, a ...
Akhgari, Amir, Laakso, Into, Seppänen-Laakso, Tuulikki, Yrjönen, Teijo, Vuorela, Heikki, Oksman-Caldentey, Kirsi-Marja, Rischer, Heiko   +7 more
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Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids

Organic & Biomolecular Chemistry, 2022
Aspidosperma terpenoid alkaloids can be quickly prepared using semisynthesis from naturally sourced tabersonine, featuring multiple oxygen-based substituents on the indole ring such as hydroxy and methoxy groups for cancer-targeted SAR studies.
Jinfeng Kang, Todd R. Lewis, Alex Gardner, Rodrigo B. Andrade, Rongsheng E. Wang   +4 more
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Indole alkaloids and terpenoids fromTabernaemontana markgrafiana

Phytochemistry, 1994
Abstract The bark of Tabernaemontana markgrafiana yielded five acetylated pentacyclic triterpenes and 24 monoterpene indole alkaloids.
Nielsen, Helene Bendstrup, Hazell, Allan, Hazell, Rita, Ghia, Felipe, Torssell, Kurt B.G.   +4 more
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Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

Frontiers of Medicine, 2014
Catharanthus roseus is one of the most extensively investigated medicinal plants, which can produce more than 130 alkaloids, including the powerful antitumor drugs vinblastine and vincristine. Here we review the recent advances in the biosynthetic pathway of terpenoid indole alkaloids (TIAs) in C.
Xiaoxuan, Zhu, Xinyi, Zeng, Chao, Sun, Shilin, Chen   +3 more
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Why are the terpenoid indole alkaloids of type I homochiral?

Chirality, 2001
AbstractIn the presence of the enzyme strictosidine synthase, the coupling reaction of secologanin and tryptamine is completely stereoselective and affords strictosidine with 3S configuration, exclusively. The stereoselectivity is transferred and retained in most indole alkaloids of type I in which C‐3 is not involved in subsequent reactions.
G, Beke, , Patthy-Lukáts A, B, Podányi, L F, Szabó   +3 more
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Biotransformation of tryptamine and secologanin into plant terpenoid indole alkaloids by transgenic yeast

Applied Microbiology and Biotechnology, 2001
A transgenic Saccharomyces cerevisiae was constructed containing the cDNAs coding for strictosidine synthase (STR) and strictosidine beta-glucosidase (SGD) from the medicinal plant Catharanthus roseus. Both enzymes are involved in the biosynthesis of terpenoid indole alkaloids. The yeast culture was found to express high levels of both enzymes.
A, Geerlings, F J, Redondo, A, Contin, J, Memelink, R, van der Heijden, R, Verpoorte   +5 more
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Alkaloids Derived from Tryptophan: Terpenoid Indole Alkaloids

2013
L-Tryptophan is an indole ring containing aromatic amino acid derived via the shikimate pathway. The tryptophan-derived alkaloids are found in eight families, of which, Apocynaceae, Loganiaceae, Rubiaceae, and Nyssaceae are the best sources. The alkaloids under discussion are theCatharanthus alkaloids, namely, ajmalicine, tabersonine, catharanthine ...
Shilpa Ramani, Nandadevi Patil, Suhas Nimbalkar, Chelliah Jayabaskaran   +3 more
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Three New Terpenoid Indole Alkaloids fromCatharanthus roseus

Planta Medica, 2010
Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (4-10), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR).
Lei, Wang, Yu, Zhang, Hong-Ping, He, Qiang, Zhang, Shi-Fei, Li, Xiao-Jiang, Hao   +5 more
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Terpenoid indole alkaloid profile changes in Catharanthus pusillus during development

Plant Science, 2001
The terpenoid indole alkaloid content of Catharanthus pusillus was investigated during development from young to old plants. Different plant organs were assessed showing that the new leaves were the main repository site with vindoline ( approximately 4.8 mg/g DW) and catharanthine ( approximately 2.2 mg/g DW) being the major metabolites with the ...
R, Zárate, C, Dirks, R, van der Heijden, R, Verpoorte   +3 more
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Advance in biosynthesis of terpenoid indole alkaloids and its regulation in Catharanthus roseus

China Journal of Chinese Materia Medica, 2016
Catharanthus roseus can produce a variety of terpenoid indole alkaloids (TIA), most of which exhibit strong pharmacological activities. Hence, biosynthesis and regulation of TIA have received recent attention. 3α (S)-strictosidine is an important node in TIA biosynthesis, which is a condensation product of secologanin and tryptamine.
Xue-Jun, Kuang, Cai-Xia, Wang, Li-Qiu, Zou, Xiao-Xuan, Zhu, Chao, Sun   +4 more
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