Results 161 to 170 of about 4,886 (206)

Revisiting the ORCA gene cluster that regulates terpenoid indole alkaloid biosynthesis in Catharanthus roseus

Plant Science, 2020
Transcription factor (TF) gene clusters in plants, such as tomato, potato, petunia, tobacco, and almond, have been characterized for their roles in the biosynthesis of diverse array of specialized metabolites. In Catharanthus roseus, three AP2/ERF TFs, ORCA3, ORCA4, and ORCA5, have been shown to be present on the same genomic scaffold, forming a ...
Sanjay Kumar, Singh, Barunava, Patra, Priyanka, Paul, Yongliang, Liu, Sitakanta, Pattanaik, Ling, Yuan   +5 more
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Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids

Organic & Biomolecular Chemistry, 2022
Aspidosperma terpenoid alkaloids can be quickly prepared using semisynthesis from naturally sourced tabersonine, featuring multiple oxygen-based substituents on the indole ring such as hydroxy and methoxy groups for cancer-targeted SAR studies.
Jinfeng Kang, Todd R. Lewis, Alex Gardner, Rodrigo B. Andrade, Rongsheng E. Wang   +4 more
openaire   +2 more sources

Indole alkaloids and terpenoids fromTabernaemontana markgrafiana

Phytochemistry, 1994
Abstract The bark of Tabernaemontana markgrafiana yielded five acetylated pentacyclic triterpenes and 24 monoterpene indole alkaloids.
Nielsen, Helene Bendstrup, Hazell, Allan, Hazell, Rita, Ghia, Felipe, Torssell, Kurt B.G.   +4 more
openaire   +1 more source

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Organic & Biomolecular Chemistry, 2018
Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.
Takayoshi Awakawa, Ikuro Abe
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Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

Frontiers of Medicine, 2014
Catharanthus roseus is one of the most extensively investigated medicinal plants, which can produce more than 130 alkaloids, including the powerful antitumor drugs vinblastine and vincristine. Here we review the recent advances in the biosynthetic pathway of terpenoid indole alkaloids (TIAs) in C.
Xiaoxuan, Zhu, Xinyi, Zeng, Chao, Sun, Shilin, Chen   +3 more
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Three New Terpenoid Indole Alkaloids fromCatharanthus roseus

Planta Medica, 2010
Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (4-10), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR).
Lei, Wang, Yu, Zhang, Hong-Ping, He, Qiang, Zhang, Shi-Fei, Li, Xiao-Jiang, Hao   +5 more
openaire   +2 more sources

Terpenoid Indole Alkaloids from Winchia calophylla

Journal of Natural Products, 2005
Three new indole alkaloids, N(4)-demethyl-12-methoxyalstogustine (1), 17-carboxyl-N(4)-methylechitamidine chloride (2), and 17-carboxyl-12-methoxy-N(4)-methylechitamidine chloride (3), along with 15 known alkaloids, were isolated from the ethanolic extract of the stem bark of Winchia calophylla.
Li-She, Gan, Sheng-Ping, Yang, Yan, Wu, Jian, Ding, Jian-Min, Yue   +4 more
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Terpenoid indole alkaloid profile changes in Catharanthus pusillus during development

Plant Science, 2001
The terpenoid indole alkaloid content of Catharanthus pusillus was investigated during development from young to old plants. Different plant organs were assessed showing that the new leaves were the main repository site with vindoline ( approximately 4.8 mg/g DW) and catharanthine ( approximately 2.2 mg/g DW) being the major metabolites with the ...
R, Zárate, C, Dirks, R, van der Heijden, R, Verpoorte   +3 more
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Alkaloids Derived from Tryptophan: Terpenoid Indole Alkaloids

2013
L-Tryptophan is an indole ring containing aromatic amino acid derived via the shikimate pathway. The tryptophan-derived alkaloids are found in eight families, of which, Apocynaceae, Loganiaceae, Rubiaceae, and Nyssaceae are the best sources. The alkaloids under discussion are theCatharanthus alkaloids, namely, ajmalicine, tabersonine, catharanthine ...
Shilpa Ramani, Nandadevi Patil, Suhas Nimbalkar, Chelliah Jayabaskaran   +3 more
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Why are the terpenoid indole alkaloids of type I homochiral?

Chirality, 2001
AbstractIn the presence of the enzyme strictosidine synthase, the coupling reaction of secologanin and tryptamine is completely stereoselective and affords strictosidine with 3S configuration, exclusively. The stereoselectivity is transferred and retained in most indole alkaloids of type I in which C‐3 is not involved in subsequent reactions.
G, Beke, , Patthy-Lukáts A, B, Podányi, L F, Szabó   +3 more
openaire   +2 more sources