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Perspectives of the Metabolic Engineering of Terpenoid Indole Alkaloids in Catharanthus roseus Hairy Roots

2013
This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, including genetic engineering and metabolic profiling, was conducted based on the gained knowledge.
Le, Zhao   +2 more
openaire   +2 more sources

Comparison of terpenoid indole alkaloid production and degradation in two cell lines of Tabernaemontana divaricata

Plant Cell Reports, 1993
Two cell lines of Tabernaemontana divaricata derived from the same suspension culture accumulate different amounts of the terpenoid indole alkaloids O-acetylvallesamine and voaphylline. [(15)N]O-acetylvallesamine and [(15)N]voaphylline were added to the suspension cultures to investigate whether the lack of accumulating capacity of one of the cell ...
D, Dagnino, J, Schripsema, R, Verpoorte
openaire   +2 more sources

Terpenoid Indole Alkaloids Biosynthesis and Metabolic Engineering in Catharanthus roseus

Journal of Integrative Plant Biology, 2007
Abstract Catharanthus roseus L. (Madagascar periwinkle) biosynthesizes a diverse array of secondary metabolites including anticancer dimeric alkaloids (vinblastine and vincristine) and antihypertensive alkaloids (ajmalicine and serpentine). The multi‐step terpenoid indole alkaloids (TIAs) biosynthetic pathway in C. roseus is complex and is
Dong‐Hui Liu   +6 more
openaire   +1 more source

Secondary Metabolism in Cell Cultures of Some Terpenoid-Indole Alkaloid Producing Plants

1988
In the past years it has been proven that large scale culturing of plant cells is feasible. The production of shikonin (1) and of ginseng biomass (2) are examples of a commercial scale production with plant cell cultures.
R. Verpoorte   +8 more
openaire   +1 more source

Terpenoid indole alkaloids, a secondary metabolite in plant defense response

2021
M. Thippeswamy   +3 more
openaire   +1 more source

Biosynthesis—II. Terpenoid indole alkaloids

1971
J. E. Saxton, A. R. Battersby
openaire   +1 more source

Revisiting the ORCA gene cluster that regulates terpenoid indole alkaloid biosynthesis in

Plant Science, 2020
Sitakanta Pattanaik   +2 more
exaly  

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