Results 81 to 90 of about 58,085 (320)

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]

, 2016
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez, Achenbach, Adelstein, Akashi, Batista, Bodansky, Cooke, Crotty, Dean, Emil R. Unanue, Ferris, Gagnerault, Garside, Gitlin, Glazier, Goodnow, Greeley, Gretz, Harbers, Henry, Henry, Henry-Bonami, Hoppu, Hu, Hulbert, Höglund, James W. Thomas, Kendall, Kendall, Kenefeck, Levisetti, Linterman, Mariño, Mohan, Mohan, Mohan, Nakayama, Noorchashm, Okada, Pape, Rasio, Reinhardt, Rojas, Roozendaal, Serreze, Silva, Takahashi, Ueno, Unanue, Victora, Victora, Vinuesa, Vomund, Williams, Xiaoxiao Wan, Yang, Zhang, Zhang, Zikherman, Zotos   +59 more
core   +2 more sources

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment

OncoImmunology, 2017
We have previously reported that direct injection of dendritic cells (DC) engineered to express the Type-1 transactivator Tbet (i.e., DC.Tbet) into murine tumors results in antitumor efficacy in association with the development of structures resembling ...
Aliyah M. Weinstein, Lu Chen, Emily A. Brzana, Prashanti R. Patil, Jennifer L. Taylor, Kellsye L. Fabian, Callen T. Wallace, Sabrina D. Jones, Simon C. Watkins, Binfeng Lu, David F. Stroncek, Timothy L. Denning, Yang-Xin Fu, Peter A. Cohen, Walter J. Storkus   +14 more
doaj   +1 more source

Biosynthesis and Functional Significance of Peripheral Node Addressin in Cancer-Associated TLO

Frontiers in Immunology, 2016
Peripheral node addressin (PNAd) marks high endothelial venules (HEV), which are crucial for the recruitment of lymphocytes into lymphoid organs in non-mucosal tissue sites.
Aliyah M. Weinstein, Walter J. Storkus
doaj   +1 more source

From mice to humans: Developments in cancer immunoediting [PDF]

, 2015
Cancer immunoediting explains the dual role by which the immune system can both suppress and/or promote tumor growth. Although cancer immunoediting was first demonstrated using mouse models of cancer, strong evidence that it occurs in human cancers is ...
Fridman, Wolf-Herman, Galon, Jerome, Smyth, Mark J., Teng, Michele W. L.   +3 more
core   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis

Nature Communications, 2023
Recent blood transcriptomic analysis of rhodesiense sleeping sickness patients has revealed that neutrophil signature genes and activation markers constitute the top indicators of trypanosomiasis-associated inflammation.
Hien Thi Thu Pham, Stefan Magez, Boyoon Choi, Bolortsetseg Baatar, Joohee Jung, Magdalena Radwanska   +5 more
doaj   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjorgren's syndrome? Association between clinical, histopathological, and molecular features: A retrospective study [PDF]

, 2014
Objectives: Several histological scoring systems, including the focus score, performed in minor salivary glands (MSGs) by hematoxylin-eosin (H&E) staining, have been employed in clinical practice to assess the inflammatory infiltrate and provide the ...
Alunno, A., Bartoloni, E., Berardicurti, O., Bistoni, O., Carubbi, F., Caterbi, S., CICCIA, Francesco, Cipriani, P., Di Benedetto, P., Gerli, R., Giacomelli, R., Ruscitti, P., TRIOLO, Giovanni   +12 more
core   +2 more sources