Results 181 to 190 of about 21,644 (273)

High efficacy therapy to prevent the formation of meningeal tertiary lymphoid organs after CXCL13 index screening in early multiple sclerosis. [PDF]

Front Neurosci
Londoño AC, Mora CA.
europepmc   +1 more source

Analysis of Peripheral T Cell Profiling and Plasma Proteomics in Advanced NSCLC Patients Treated With Atezolizumab

Cancer Science, EarlyView.
This study found immune markers that may predict how well patients with advanced lung cancer respond to atezolizumab. Higher levels of certain T cells were linked to better survival. Specific patterns suggested a worse prognosis for some patients. ABSTRACT We investigated immunologic biomarkers that predict outcomes of patients with previously treated ...
Atsuto Mouri, Hiroshi Kagamu, Koji Tamada, Makoto Nishio, Hiroaki Akamatsu, Yasushi Goto, Hidetoshi Hayashi, Satoru Miura, Akihiko Gemma, Ichiro Yoshino, Toshihiro Misumi, Ryota Saito, Noriko Yanagitani, Fujita Masaki, Hiroshi Nokihara, Kazumi Nishino, Masahiro Seike, Tetsunari Hase, Osamu Hataji, Hiroaki Takeoka, Yosuke Kawashima, Hirotaka Kuroki, Masamichi Sugimoto, Hiroshi Kuriki, Tetsuya Mitsudomi   +24 more
wiley   +1 more source

Targeting Ikaros and Aiolos: Next‐Generation Cereblon E3 Ligase Modulators in MM

European Journal of Haematology, EarlyView.
The graphical abstract illustrates the mechanism of action of cereblon E3 ligase modulators (CELMoDs) in multiple myeloma, highlighting cereblon‐mediated degradation of IKZF1 and IKZF3. Compared with classical immunomodulatory drugs (IMiDs), CELMoDs induce deeper IKZF1/3 depletion, leading to more pronounced suppression of the IRF4–MYC survival axis ...
Maria Eugenia Alvaro, Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma. [PDF]

Cancer Sci, 2019
Kuwabara S, Tsuchikawa T, Nakamura T, Hatanaka Y, Hatanaka KC, Sasaki K, Ono M, Umemoto K, Suzuki T, Sato O, Hane Y, Nakanishi Y, Asano T, Ebihara Y, Kurashima Y, Noji T, Murakami S, Okamura K, Shichinohe T, Hirano S.   +19 more
europepmc   +1 more source

Principles of whole organ transplantation [PDF]

, 1984
Iwatsuki, S, Shaw, BW, Starzl, TE
core  

Silent pressure: Unveiling spinal lymphoma in horses and its parallels to other species

Equine Veterinary Education, EarlyView.
Summary Though the nervous system is an uncommon location for lymphoma, the disease should remain a differential diagnosis in some cases of ataxia in equids. Diagnosis of lymphoma can be challenging, although a combination of cytology, histopathology and immunophenotyping can aid in definitive diagnosis and therefore more accurately guide treatment and
H. E. Taylor, D. Luethy
wiley   +1 more source

Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 proteins

The FEBS Journal, EarlyView.
Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández, Théo Paris, Maria Demou, Catherine Birck, Christina Begon‐Pescia, Juan Francisco Rodríguez Vidal, Sylwia D. Tyrkalska, Charlotte Bureau, Catherine Gonzalez, Juliette Gracia, Etienne Lelièvre, Victoriano Mulero, Mai Nguyen‐Chi, Laure Yatime   +13 more
wiley   +1 more source

Tertiary lymphoid organs in wild boar exposed to a low-virulent isolate of African swine fever virus. [PDF]

Vet Q
Porras N, Sánchez-Vizcaíno JM, Rodríguez-Bertos A, Kosowska A, Barasona JÁ.   +4 more
europepmc   +1 more source

Elementary immunology [PDF]

, 2017
Gogolák, Péter, Koncz, Gábor
core  

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source