Results 181 to 190 of about 6,745 (243)
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Cancer Research, 2023
Abstract Introduction: The presence of TLS in tumors is associated with improved efficacy of immunotherapy in various types of cancer. The significance of TLS in patients with ESCC has been sporadically reported. The study aimed to investigate the prognostic significance of TLS in patients with locally advanced ESCC receiving neoadjuvant
Ta-Chen Huang +7 more
openaire +2 more sources
Abstract Introduction: The presence of TLS in tumors is associated with improved efficacy of immunotherapy in various types of cancer. The significance of TLS in patients with ESCC has been sporadically reported. The study aimed to investigate the prognostic significance of TLS in patients with locally advanced ESCC receiving neoadjuvant
Ta-Chen Huang +7 more
openaire +2 more sources
Journal of Clinical Oncology, 2023
e20520 Background: Recent data suggested immune infiltrates in TLS around tumor bed may be a favorable predictive factor for immunotherapy in various cancers. TLS have been suggested to be correlated with inflamed immune phenotype and relevant inflammatory gene signatures of adaptive immunity.
Sanghoon Song +11 more
openaire +2 more sources
e20520 Background: Recent data suggested immune infiltrates in TLS around tumor bed may be a favorable predictive factor for immunotherapy in various cancers. TLS have been suggested to be correlated with inflamed immune phenotype and relevant inflammatory gene signatures of adaptive immunity.
Sanghoon Song +11 more
openaire +2 more sources
Cancer Research
Abstract Although TLS status possesses prognostic significance in PDAC and can potentially affect chemotherapy outcomes, there is currently a notable lack of RNA sequencing (RNA-seq) models that specialize in TLS identification and classification in PDAC. Here, we developed a model for predicting TLS status (high or low) based on RNA-seq
Alexandra Livanova +11 more
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Abstract Although TLS status possesses prognostic significance in PDAC and can potentially affect chemotherapy outcomes, there is currently a notable lack of RNA sequencing (RNA-seq) models that specialize in TLS identification and classification in PDAC. Here, we developed a model for predicting TLS status (high or low) based on RNA-seq
Alexandra Livanova +11 more
openaire +2 more sources
Journal of Clinical Oncology
3135 Background: Recent data indicate that immune cells present in the TLS within the tumor microenvironment (TME) could potentially serve as a favorable predictor for immune checkpoint inhibitor (ICI) therapy. To examine this further, AI model was created to provide an assessment of TLS in H&E WSI, and to determine its correlation with survival ...
Leeseul Kim +7 more
openaire +2 more sources
3135 Background: Recent data indicate that immune cells present in the TLS within the tumor microenvironment (TME) could potentially serve as a favorable predictor for immune checkpoint inhibitor (ICI) therapy. To examine this further, AI model was created to provide an assessment of TLS in H&E WSI, and to determine its correlation with survival ...
Leeseul Kim +7 more
openaire +2 more sources
Journal of Clinical Oncology, 2022
3142 Background: Previous studies of non-small cell lung cancer (NSCLC) have shown that TLS can be predictive of therapy response and a positive prognostic factor for survival. Currently, TLS identification is manually performed by pathologists with limited morphological criteria. Standardizing TLS detection with an automated DIA workflow could guide
Vladimir Kushnarev +15 more
openaire +1 more source
3142 Background: Previous studies of non-small cell lung cancer (NSCLC) have shown that TLS can be predictive of therapy response and a positive prognostic factor for survival. Currently, TLS identification is manually performed by pathologists with limited morphological criteria. Standardizing TLS detection with an automated DIA workflow could guide
Vladimir Kushnarev +15 more
openaire +1 more source
Cancer Research, 2023
Abstract Introduction Lymphoid aggregates are commonly associated with better prognosis and enhanced response to immune modulators in several cancers. Considering the immune-privileged status of the eye we sought to investigate the immune, genomic and prognostic significance of 12-chemokine TLS gene signature in UM patients.
Hassan Mohammed Abushukair +5 more
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Abstract Introduction Lymphoid aggregates are commonly associated with better prognosis and enhanced response to immune modulators in several cancers. Considering the immune-privileged status of the eye we sought to investigate the immune, genomic and prognostic significance of 12-chemokine TLS gene signature in UM patients.
Hassan Mohammed Abushukair +5 more
openaire +1 more source
Cancer Research, 2022
Abstract Background: Previous studies showed conflicting results regarding association between stromal tumor infiltrating lymphocytes (sTIL) and outcome in HER2+ breast cancer. While sTIL were not associated with outcome in patients (pts) treated with trastuzumab in N9831, immune functions genes are linked to outcome in these pts. TLS is
Saranya Chumsri +9 more
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Abstract Background: Previous studies showed conflicting results regarding association between stromal tumor infiltrating lymphocytes (sTIL) and outcome in HER2+ breast cancer. While sTIL were not associated with outcome in patients (pts) treated with trastuzumab in N9831, immune functions genes are linked to outcome in these pts. TLS is
Saranya Chumsri +9 more
openaire +1 more source
Cancer Research, 2022
Abstract Immune checkpoint blockade (ICB) therapy has revolutionized the landscape of cancer therapy in multiple tumor types since Ipilimumab, the first ICB agent, was approved for the treatment of metastatic melanoma is 2011. Current predictive biomarkers for therapy response include PD-L1 expression, tumor mutational burden (TMB) and ...
Harry Nunns +7 more
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Abstract Immune checkpoint blockade (ICB) therapy has revolutionized the landscape of cancer therapy in multiple tumor types since Ipilimumab, the first ICB agent, was approved for the treatment of metastatic melanoma is 2011. Current predictive biomarkers for therapy response include PD-L1 expression, tumor mutational burden (TMB) and ...
Harry Nunns +7 more
openaire +1 more source
Cancer Research, 2021
Abstract The absence of conventional lymphatic access to the brain parenchyma restricts the capacity of the peripheral immune system to recognize and elicit durable responses against glioma antigens. In some peripheral solid tumor types and autoimmune diseases such as multiple sclerosis, the spontaneous development of tertiary lymphoid ...
Kira Morgan Downey +4 more
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Abstract The absence of conventional lymphatic access to the brain parenchyma restricts the capacity of the peripheral immune system to recognize and elicit durable responses against glioma antigens. In some peripheral solid tumor types and autoimmune diseases such as multiple sclerosis, the spontaneous development of tertiary lymphoid ...
Kira Morgan Downey +4 more
openaire +1 more source
Journal of Clinical Oncology, 2022
2511 Background: While ICB has significantly improved clinical outcomes across several cancer types, only 15-20% of patients develop a durable response. Thus, novel and targetable biomarkers are needed. There is increased appreciation of the role of the gut microbiome, and TLS and B-cells in the TME in response to ICB.
Elise F Nassif +19 more
openaire +1 more source
2511 Background: While ICB has significantly improved clinical outcomes across several cancer types, only 15-20% of patients develop a durable response. Thus, novel and targetable biomarkers are needed. There is increased appreciation of the role of the gut microbiome, and TLS and B-cells in the TME in response to ICB.
Elise F Nassif +19 more
openaire +1 more source