Results 181 to 190 of about 2,945 (208)

TERTIARY LYMPHOID STRUCTURES (TLS) EXPANSION PARALLELS ILEITIS PROGRESSION IN TNFΔARE MICE, REQUIRES β7 INTEGRIN AND CCR7, AND DECREASES IN SIZE AFTER GLUCOCORTICOID ADMINISTRATION

Gastroenterology
Abstract BACKGROUND Tertiary lymphoid structures (TLS) arise at sites of chronic inflammation, including the chronically inflamed terminal ileum in Crohn’s disease (CD), but their developmental progression, molecular requirements and responsiveness to anti-inflammatories are not completely ...
Prabhdeep Kaur, Marisol Veny, Paul Jedlicka, Eóin McNamee, Jesus Rivera-Nieves   +4 more
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Abstract 6826: Comparative analysis of a predictive transcriptomic model and functional gene expression signatures (FGES) for tertiary lymphoid structure (TLS) detection in lung adenocarcinoma (LUAD)

Cancer Research
Abstract Background: TLS are recognized as significant biomarkers for patient prognosis and therapy selection. In current clinical practice, TLS are often detected by manual assessment of H&E slides, which has been associated with reproducibility issues.
Nadezhda Lukashevich, Daniil Dymov, Aleksandr Sarachakov, Sofya Kust, Anna Love, Ivan Valiev, Dmitry Ivchenkov, Alexander Bagaev, Viktor Svekolkin, Nikita Kotlov, Vladimir Kushnarev   +10 more
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Abstract 6741: Tertiary lymphoid structure (TLS)-associated immune circuits define response to durvalumab, trastuzumab, and pertuzumab (DTP) in HER2-enriched early breast cancer

Cancer Research
Abstract Background: Chemotherapy-free regimens combining HER2-targeted therapy with immune checkpoint blockade are emerging as promising strategies in HER2-Enriched breast cancer. In our Phase II trial of durvalumab, trastuzumab, and pertuzumab (DTP), ER-negative, PR-negative, HER2-Enriched ...
Mailin Li, Xen Ping Hoi, Jenying Deng, Junjun Zheng, Rabia Hashmani, Recep Bayraktar, Wei Qian, Jianying Zhou, Jian Guan, Kai Sun, Hanh Mai, Tiffany Sheu, Susan Haley, Mary Schwartz, Sunil Mathur, Stephen T. Wong, Fotis Nikolo, Keith Syson Chan, Polly Niravath, Jenny C. Chang   +19 more
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Abstract LB257: MST-0312: Targeted LTBR agonist designed to induce tertiary lymphoid structures (TLS) and high endothelial venules (HEV) for the treatment of solid tumors

Cancer Research
Abstract The presence of tertiary lymphoid structures (TLSs) and associated high endothelial venules (HEVs) in tumors is recognized as a hallmark of effective antitumor immunity. Improved prognosis and treatment outcomes across tumor stages and modalities (including immune checkpoint blockade, VEGF/PD1, chemotherapy and radiotherapy ...
Marta Lewandowska, Ann White, Lucy Penfold, Fevzi Demircioglu, Charly Brown, Robert de Jonge, Ray Jupp, Pascal Merchiers   +7 more
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SO016/#846  Deep learning for spatial distribution of tertiary lymphoid structures (TLS) and efficacy of immunotherapy for endometrial cancer

Closing Session: the Development of Prognosis and Predictive Markers, 2023
Junzo Hamanishi, Haruka Suzuki, Akihiko Ueda, Ken Yamaguchi, Masaki Mandai   +4 more
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Artificial intelligence (AI) -powered H&E whole-slide image (WSI) analysis of tertiary lymphoid structure (TLS) to predict response to immunotherapy in non-small cell lung cancer (NSCLC).

Journal of Clinical Oncology
3135 Background: Recent data indicate that immune cells present in the TLS within the tumor microenvironment (TME) could potentially serve as a favorable predictor for immune checkpoint inhibitor (ICI) therapy. To examine this further, AI model was created to provide an assessment of TLS in H&E WSI, and to determine its correlation with survival ...
Leeseul Kim, Sangwon SHIN, Soo Ick Cho, Wonkyung Jung, Sanghoon Song, Liam IL Young Chung, Chan-Young Ock, Young Kwang Chae   +7 more
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Abstract PS2-09-08: Tertiary lymphoid structure (TLS)-related gene expression and outcomes in HER2-Positive (HER2+) breast cancer (BC) in the Real-World Database

Clinical Cancer Research
Abstract Background: Tertiary lymphoid structures (TLS), which are organized ectopic lymphoid aggregates resembling secondary lymphoid organs, have been associated with improved outcomes across various cancer types.
S. Chumsri, S. Deshmukh, Y. Liu, S. Wu, J. Xiu, N. Norton, S. Shipra Gandhi, E. Torres, M. Lustberg, E. Perez, A. Nassar, G. Sledge, E. Thompson, K. Knutson   +13 more
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Abstract PO4-25-04: MHC Class I and II Expression, Functional Tertiary Lymphoid Structure (TLS), and Outcomes in Early-Stage HER2-Positive (HER2+) Breast Cancer in NCCTG N9831 (Alliance)

Cancer Research
Abstract Background: Tertiary lymphoid structure (TLS) is an organized form of ectopic lymphoid aggregates (LA) with secondary lymphoid organ structure. Several studies showed that the presence of TLS associates with improved outcomes in multiple cancers when treated with immune checkpoint inhibitors.
Saranya Chumsri, Tracy Shachner, Zhuo Li, Nadine Norton, Alvaro Moreno-Aspitia, Gerardo Colon-Otero, Edith Perez, Aziza Nassar, E. Thompson, Keith Knutson   +9 more
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Abstract 2919: A little STING spices up tertiary lymphoid structures: Therapeutic induction of mature TLS by STING and lymphotoxin-β receptor activation confers immune protection against cancer metastasis

Cancer Research
Abstract Significant clinical evidence demonstrates an association of tertiary lymphoid structure (TLS) formation with cancer survival. Clinically translatable pharmacologic/biologic agents that induce TLS-rich tumor immune environment could provide a breakthrough strategy to treat therapy-resistant cancers.
Yasuhiro Kikuchi, Maxwell Duah, Fumiaki Kanamori, Masanobu Komatsu   +3 more
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Abstract 3358: Tertiary lymphoid structures (TLS) estimated by AI tools from digital H&E slides significantly enhance survival prediction in high-risk AJCC stages III/IV melanoma

Cancer Research
Abstract Tertiary lymphoid structures (TLS) in tumors have emerged as novel disease prognostic and predictive biomarkers with immunotherapy. Recent advances in whole-slide image (WSI) digitization of pathology slides and AI tools are making in situ prediction of TLS more feasible. Methods:
Ahmad A. Tarhini, Tingyi Li, Ranran Tao, Sandra J. Lee, Islam Eljilany, F. Stephen Hodi, Howard Streicher, Arivarasan Karunamurthy, John M. Kirkwood, Xuefeng Wang   +9 more
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