Results 171 to 180 of about 2,945 (208)

Abstract 74: Engineering tertiary lymphoid structures for glioblastoma: A novel gene combination promotes therapeutic TLS formation in an immune-competent mouse model of GBM

Cancer Research, 2021
Abstract The absence of conventional lymphatic access to the brain parenchyma restricts the capacity of the peripheral immune system to recognize and elicit durable responses against glioma antigens. In some peripheral solid tumor types and autoimmune diseases such as multiple sclerosis, the spontaneous development of tertiary lymphoid ...
Kira Morgan Downey, Bindu Hegde, Zinal Chheda, Jason Zhang, Hideho Okada   +4 more
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Identifying gut microbial signatures associated with B cells and tertiary lymphoid structures (TLS) in the tumor microenvironment (TME) in response to immune checkpoint blockade (ICB).

Journal of Clinical Oncology, 2022
2511 Background: While ICB has significantly improved clinical outcomes across several cancer types, only 15-20% of patients develop a durable response. Thus, novel and targetable biomarkers are needed. There is increased appreciation of the role of the gut microbiome, and TLS and B-cells in the TME in response to ICB.
Elise F Nassif, Manoj Chelvanambi, Lili Chen, Chia-Chin Wu, Ashish Damania, Emily Zhi-Yun Keung, Russell G. Witt, Michael White, Nadim J. Ajami, Matthew C. Wong, Neeta Somaiah, Boris Sepesi, Sreyashi Basu, James Patrick Allison, Padmanee Sharma, Kevin McBride, Wolf-Hervé Fridman, Jennifer Ann Wargo, Tina Cascone, Christina Lynn Roland   +19 more
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Significance of intratumoral tertiary lymphoid structure (TLS) as predictictive factors of nivolumab therapy after conversion surgery for unresectable gastric cancer: A retrospective study.

Journal of Clinical Oncology, 2020
412 Background: Conversion surgery for unresectable advanced gastric cancer has been increasing with the development of chemotherapy. Adjuvant chemotherapy regimens after conversion surgery have not been standardized. The main mechanism of nivolumab is augmentation of antitumor immune response of tumor infiltrating cytotoxic T cells (CTL) to cancer ...
Hiroaki Tanaka, Takuya Mori, Kenjiro Kimura, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira   +5 more
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Artificial intelligence (AI) –powered H&E whole-slide image (WSI) analysis of tertiary lymphoid structure (TLS) correlates with immune phenotype and related molecular signatures in non–small-cell lung cancer.

Journal of Clinical Oncology, 2023
e20520 Background: Recent data suggested immune infiltrates in TLS around tumor bed may be a favorable predictive factor for immunotherapy in various cancers. TLS have been suggested to be correlated with inflamed immune phenotype and relevant inflammatory gene signatures of adaptive immunity.
Sanghoon Song, Wonkyung Jung, Soo Ick Cho, Juneyoung Ro, Hajin Lee, Minuk Ma, Seonwook Park, Donggeun Yoo, Leeseul Kim, Liam Il-Young Chung, Young Kwang Chae, Chan-Young Ock   +11 more
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Abstract 4909: An RNA-based model for tertiary lymphoid structure (TLS) prediction and classification in pancreatic adenocarcinoma (PDAC)

Cancer Research
Abstract Although TLS status possesses prognostic significance in PDAC and can potentially affect chemotherapy outcomes, there is currently a notable lack of RNA sequencing (RNA-seq) models that specialize in TLS identification and classification in PDAC. Here, we developed a model for predicting TLS status (high or low) based on RNA-seq
Alexandra Livanova, Andrey Tyshevich, Andrey Kravets, Stanislav Kurpe, Nadezhda Lukashevich, Dmitry Ivchenkov, Daniil Dymov, Anna Belozerova, Kirill Kryukov, Aleksandr Sarachakov, Viktor Svekolkin, Vladimir Kushnarev   +11 more
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Abstract 2219: CXCL13 secretion and immobilization show distinct geographies within secondary and tertiary lymphoid structures (TLS).

Cancer Research
Abstract The purpose of this study is to investigate the formation and maintenance of germinal centers in TLS by defining mechanisms and spatial patterns of CXCL13 chemokine gradients in tumor tissue. In secondary lymphoid tissue, it is recognized that CXCL13 is immobilized by follicular dendritic cells (FDCs), but the mechanisms of ...
Jonathan Rex Skidmore, Aleksandra Ogurtsova, Grant Salvucci, Victoria Jacobs, Logan Engle, Robert A. Anders, Drew M. Pardoll, Janis Marie Taube   +7 more
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Abstract 7761: Tertiary lymphoid structure (TLS) representative cells elicit response to anti-PD-1+ therapy in a cold tumor

Cancer Research
Abstract The composition and activation phenotype of immune cells within the tumor microenvironment (TME) can significantly influence therapeutic response to PD-1 based immunotherapy. Using the Farcast TruTumor histoculture platform, we investigated potential factors contributing to the unexpected anti-PD-1 responsiveness in an immune
Satish Sankaran, Priyanka Chevour, Kowshik Jaganathan, Biswajit Das, Moumita Nath, Abdul Haseeb, Jobin K Paul, Vasanthakumar A, Oliyarasi M, Rajashekar M, Jayaprakash C, Venkatesh T, MS Ganesh, Amritha Prabha, Prakash BV, Upendra K, Méhul Kapur, Ritu Malhotra, Govindaraj K, null Pavithira., Mohit Malhotra   +20 more
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A comprehensive evaluation of gene expression-based signatures for detecting tertiary lymphoid structures (TLS) in metastatic renal cell carcinoma (mRCC).

Journal of Clinical Oncology
591 Background: TLS are organized lymphoid aggregates linked to improved response to immunotherapy in multiple cancers, including mRCC. Traditionally, TLS assessment relies on pathological staining of tumor sections.
Eddy Saad, Nourhan El Ahmar, Berkay Simsek, Opeyemi Jegede, Sayed Matar, Razan Assaad Mohanna, Emre Yekeduz, David F. McDermott, Elizabeth R. Plimack, Jeffrey A. Sosman, Naomi Balzer Haas, Michael E. Hurwitz, Hans J. Hammers, Eliezer Mendel Van Allen, Toni K. Choueiri, Michael B. Atkins, Sabina Signoretti, David A. Braun   +17 more
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[Clinical Significance and Therapeutic Applications of Tertiary Lymphoid Structures(TLS)in Gynecological Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy
Tertiary lymphoid structures(TLS)are gaining attention as sites for anti‒tumor immune responses. They are observed in gynecological tumor tissues, including common gynecological cancers such as endometrial, cervical, and ovarian cancers. The distribution and maturity of TLS, along with molecular genetic factors and patient prognosis, are being studied.
Junzo, Hamanishi, Kohei, Hamada, Masaki, Mandai   +2 more
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Abstract P2-08-47: Evaluation of stromal tumor-infiltrating lymphocytes (sTIL) and tertiary lymphoid structures (TLS) in early breast cancer patients with triple negative breast cancer(TNBC) included in a prospective study of neoadjuvant chemotherapy (NAC) with Epirubicin and cyclophosphamide (EC) and carboplatin-paclitaxel (PC) (BSMO 2014-01)

Cancer Research, 2019
Abstract Background: BSMO 2014-01 is a completed prospective phase 2 study evaluating the efficacy of neoadjuvant EC and PC. One of the secondary endpoints was the correlation of sTIL with response, pCR and survival. We also assessed the relationship between sTIL and TLS in the diagnostic biopsies.
C Fontaine, G Van den Eynden, R de Wind, A Boisson, V Renard, H Van den Bulck, P Vuylsteke, P Glorieux, C Dopchie, L Decoster, J De Grève, A Awada, H Wildiers, K Willard-Gallo   +13 more
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