Results 151 to 160 of about 2,807 (182)

Abstract 4909: An RNA-based model for tertiary lymphoid structure (TLS) prediction and classification in pancreatic adenocarcinoma (PDAC)

Cancer Research
Abstract Although TLS status possesses prognostic significance in PDAC and can potentially affect chemotherapy outcomes, there is currently a notable lack of RNA sequencing (RNA-seq) models that specialize in TLS identification and classification in PDAC. Here, we developed a model for predicting TLS status (high or low) based on RNA-seq
Alexandra Livanova, Andrey Tyshevich, Andrey Kravets, Stanislav Kurpe, Nadezhda Lukashevich, Dmitry Ivchenkov, Daniil Dymov, Anna Belozerova, Kirill Kryukov, Aleksandr Sarachakov, Viktor Svekolkin, Vladimir Kushnarev   +11 more
openaire   +1 more source

Automated detection of tertiary lymphoid structures (TLS) on whole-slide pathology images using an improved YOLO-v12 model and validation of a TLS structural prognostic index (TLS-SPI) across multi-cancer TCGA cohorts.

Journal of Clinical Oncology
e13670 Background: Tertiary lymphoid structures (TLS) are important biomarkers reflecting the tumor immune microenvironment and are closely associated with patient prognosis.
Qinrui Jiang, Hongyu Xie, Na Hong, Ziqi Jin, Geye Tang, Xiaohan Liu, Qiong Huang, Min Shi   +7 more
openaire   +1 more source

Abstract 7761: Tertiary lymphoid structure (TLS) representative cells elicit response to anti-PD-1+ therapy in a cold tumor

Cancer Research
Abstract The composition and activation phenotype of immune cells within the tumor microenvironment (TME) can significantly influence therapeutic response to PD-1 based immunotherapy. Using the Farcast TruTumor histoculture platform, we investigated potential factors contributing to the unexpected anti-PD-1 responsiveness in an immune
Satish Sankaran, Priyanka Chevour, Kowshik Jaganathan, Biswajit Das, Moumita Nath, Abdul Haseeb, Jobin K Paul, Vasanthakumar A, Oliyarasi M, Rajashekar M, Jayaprakash C, Venkatesh T, MS Ganesh, Amritha Prabha, Prakash BV, Upendra K, Méhul Kapur, Ritu Malhotra, Govindaraj K, null Pavithira., Mohit Malhotra   +20 more
openaire   +1 more source

A comprehensive evaluation of gene expression-based signatures for detecting tertiary lymphoid structures (TLS) in metastatic renal cell carcinoma (mRCC).

Journal of Clinical Oncology
591 Background: TLS are organized lymphoid aggregates linked to improved response to immunotherapy in multiple cancers, including mRCC. Traditionally, TLS assessment relies on pathological staining of tumor sections.
Eddy Saad, Nourhan El Ahmar, Berkay Simsek, Opeyemi Jegede, Sayed Matar, Razan Assaad Mohanna, Emre Yekeduz, David F. McDermott, Elizabeth R. Plimack, Jeffrey A. Sosman, Naomi Balzer Haas, Michael E. Hurwitz, Hans J. Hammers, Eliezer Mendel Van Allen, Toni K. Choueiri, Michael B. Atkins, Sabina Signoretti, David A. Braun   +17 more
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[Clinical Significance and Therapeutic Applications of Tertiary Lymphoid Structures(TLS)in Gynecological Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy
Tertiary lymphoid structures(TLS)are gaining attention as sites for anti‒tumor immune responses. They are observed in gynecological tumor tissues, including common gynecological cancers such as endometrial, cervical, and ovarian cancers. The distribution and maturity of TLS, along with molecular genetic factors and patient prognosis, are being studied.
Junzo, Hamanishi, Kohei, Hamada, Masaki, Mandai   +2 more
openaire   +1 more source

AI-powered assessment of tertiary lymphoid structures (TLS) from H&E whole-slide images as a prognostic tool in HNSCC.

Journal of Clinical Oncology
6024 Background: Tertiary lymphoid structures (TLS) are recognized prognostic markers in Head and Neck Squamous Cell Carcinoma (HNSCC), yet manual assessment from H&E whole-slide images (WSI) remains subjective and labor-intensive, limiting clinical ...
Jiyoon Lim, Anthony Wong, Shinkyo Yoon, Seyoung Seo, Young Kwang Chae   +4 more
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TERTIARY LYMPHOID STRUCTURES (TLS) EXPANSION PARALLELS ILEITIS PROGRESSION IN TNFΔARE MICE, REQUIRES β7 INTEGRIN AND CCR7, AND DECREASES IN SIZE AFTER GLUCOCORTICOID ADMINISTRATION

Gastroenterology
Abstract BACKGROUND Tertiary lymphoid structures (TLS) arise at sites of chronic inflammation, including the chronically inflamed terminal ileum in Crohn’s disease (CD), but their developmental progression, molecular requirements and responsiveness to anti-inflammatories are not completely ...
Prabhdeep Kaur, Marisol Veny, Paul Jedlicka, Eóin McNamee, Jesus Rivera-Nieves   +4 more
openaire   +1 more source

SO016/#846  Deep learning for spatial distribution of tertiary lymphoid structures (TLS) and efficacy of immunotherapy for endometrial cancer

International Journal of Gynecological Cancer, 2023
Junzo Hamanishi, Haruka Suzuki, Akihiko Ueda, K.e.n. Yamaguchi, Masaki Mandai   +4 more
openaire   +1 more source

Abstract 6741: Tertiary lymphoid structure (TLS)-associated immune circuits define response to durvalumab, trastuzumab, and pertuzumab (DTP) in HER2-enriched early breast cancer

Cancer Research
Abstract Background: Chemotherapy-free regimens combining HER2-targeted therapy with immune checkpoint blockade are emerging as promising strategies in HER2-Enriched breast cancer. In our Phase II trial of durvalumab, trastuzumab, and pertuzumab (DTP), ER-negative, PR-negative, HER2-Enriched ...
Mailin Li, Xen Ping Hoi, Jenying Deng, Junjun Zheng, Rabia Hashmani, Recep Bayraktar, Wei Qian, Jianying Zhou, Jian Guan, Kai Sun, Hanh Mai, Tiffany Sheu, Susan Haley, Mary Schwartz, Sunil Mathur, Stephen T. Wong, Fotis Nikolo, Keith Syson Chan, Polly Niravath, Jenny C. Chang   +19 more
openaire   +1 more source

Abstract LB257: MST-0312: Targeted LTBR agonist designed to induce tertiary lymphoid structures (TLS) and high endothelial venules (HEV) for the treatment of solid tumors

Cancer Research
Abstract The presence of tertiary lymphoid structures (TLSs) and associated high endothelial venules (HEVs) in tumors is recognized as a hallmark of effective antitumor immunity. Improved prognosis and treatment outcomes across tumor stages and modalities (including immune checkpoint blockade, VEGF/PD1, chemotherapy and radiotherapy ...
Marta Lewandowska, Ann White, Lucy Penfold, Fevzi Demircioglu, Charly Brown, Robert de Jonge, Ray Jupp, Pascal Merchiers   +7 more
openaire   +1 more source