Results 151 to 160 of about 3,198 (184)

Abstract 4909: An RNA-based model for tertiary lymphoid structure (TLS) prediction and classification in pancreatic adenocarcinoma (PDAC)

Cancer Research
Abstract Although TLS status possesses prognostic significance in PDAC and can potentially affect chemotherapy outcomes, there is currently a notable lack of RNA sequencing (RNA-seq) models that specialize in TLS identification and classification in PDAC. Here, we developed a model for predicting TLS status (high or low) based on RNA-seq
Alexandra Livanova, Andrey Tyshevich, Andrey Kravets, Stanislav Kurpe, Nadezhda Lukashevich, Dmitry Ivchenkov, Daniil Dymov, Anna Belozerova, Kirill Kryukov, Aleksandr Sarachakov, Viktor Svekolkin, Vladimir Kushnarev   +11 more
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Abstract 2219: CXCL13 secretion and immobilization show distinct geographies within secondary and tertiary lymphoid structures (TLS).

Cancer Research
Abstract The purpose of this study is to investigate the formation and maintenance of germinal centers in TLS by defining mechanisms and spatial patterns of CXCL13 chemokine gradients in tumor tissue. In secondary lymphoid tissue, it is recognized that CXCL13 is immobilized by follicular dendritic cells (FDCs), but the mechanisms of ...
Jonathan Rex Skidmore, Aleksandra Ogurtsova, Grant Salvucci, Victoria Jacobs, Logan Engle, Robert A. Anders, Drew M. Pardoll, Janis Marie Taube   +7 more
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Automated detection of tertiary lymphoid structures (TLS) on whole-slide pathology images using an improved YOLO-v12 model and validation of a TLS structural prognostic index (TLS-SPI) across multi-cancer TCGA cohorts.

Journal of Clinical Oncology
e13670 Background: Tertiary lymphoid structures (TLS) are important biomarkers reflecting the tumor immune microenvironment and are closely associated with patient prognosis.
Qinrui Jiang, Hongyu Xie, Na Hong, Ziqi Jin, Geye Tang, Xiaohan Liu, Qiong Huang, Min Shi   +7 more
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A comprehensive evaluation of gene expression-based signatures for detecting tertiary lymphoid structures (TLS) in metastatic renal cell carcinoma (mRCC).

Journal of Clinical Oncology
591 Background: TLS are organized lymphoid aggregates linked to improved response to immunotherapy in multiple cancers, including mRCC. Traditionally, TLS assessment relies on pathological staining of tumor sections.
Eddy Saad, Nourhan El Ahmar, Berkay Simsek, Opeyemi Jegede, Sayed Matar, Razan Assaad Mohanna, Emre Yekeduz, David F. McDermott, Elizabeth R. Plimack, Jeffrey A. Sosman, Naomi Balzer Haas, Michael E. Hurwitz, Hans J. Hammers, Eliezer Mendel Van Allen, Toni K. Choueiri, Michael B. Atkins, Sabina Signoretti, David A. Braun   +17 more
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Abstract 7761: Tertiary lymphoid structure (TLS) representative cells elicit response to anti-PD-1+ therapy in a cold tumor

Cancer Research
Abstract The composition and activation phenotype of immune cells within the tumor microenvironment (TME) can significantly influence therapeutic response to PD-1 based immunotherapy. Using the Farcast TruTumor histoculture platform, we investigated potential factors contributing to the unexpected anti-PD-1 responsiveness in an immune
Satish Sankaran, Priyanka Chevour, Kowshik Jaganathan, Biswajit Das, Moumita Nath, Abdul Haseeb, Jobin K Paul, Vasanthakumar A, Oliyarasi M, Rajashekar M, Jayaprakash C, Venkatesh T, MS Ganesh, Amritha Prabha, Prakash BV, Upendra K, Méhul Kapur, Ritu Malhotra, Govindaraj K, null Pavithira., Mohit Malhotra   +20 more
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AI-powered assessment of tertiary lymphoid structures (TLS) from H&E whole-slide images as a prognostic tool in HNSCC.

Journal of Clinical Oncology
6024 Background: Tertiary lymphoid structures (TLS) are recognized prognostic markers in Head and Neck Squamous Cell Carcinoma (HNSCC), yet manual assessment from H&E whole-slide images (WSI) remains subjective and labor-intensive, limiting clinical ...
Jiyoon Lim, Anthony Wong, Shinkyo Yoon, Seyoung Seo, Young Kwang Chae   +4 more
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[Clinical Significance and Therapeutic Applications of Tertiary Lymphoid Structures(TLS)in Gynecological Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy
Tertiary lymphoid structures(TLS)are gaining attention as sites for anti‒tumor immune responses. They are observed in gynecological tumor tissues, including common gynecological cancers such as endometrial, cervical, and ovarian cancers. The distribution and maturity of TLS, along with molecular genetic factors and patient prognosis, are being studied.
Junzo, Hamanishi, Kohei, Hamada, Masaki, Mandai   +2 more
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TERTIARY LYMPHOID STRUCTURES (TLS) EXPANSION PARALLELS ILEITIS PROGRESSION IN TNFΔARE MICE, REQUIRES β7 INTEGRIN AND CCR7, AND DECREASES IN SIZE AFTER GLUCOCORTICOID ADMINISTRATION

Gastroenterology
Abstract BACKGROUND Tertiary lymphoid structures (TLS) arise at sites of chronic inflammation, including the chronically inflamed terminal ileum in Crohn’s disease (CD), but their developmental progression, molecular requirements and responsiveness to anti-inflammatories are not completely ...
Prabhdeep Kaur, Marisol Veny, Paul Jedlicka, Eóin McNamee, Jesus Rivera-Nieves   +4 more
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SO016/#846  Deep learning for spatial distribution of tertiary lymphoid structures (TLS) and efficacy of immunotherapy for endometrial cancer

International Journal of Gynecological Cancer, 2023
Junzo Hamanishi, Haruka Suzuki, Akihiko Ueda, K.e.n. Yamaguchi, Masaki Mandai   +4 more
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Abstract 6826: Comparative analysis of a predictive transcriptomic model and functional gene expression signatures (FGES) for tertiary lymphoid structure (TLS) detection in lung adenocarcinoma (LUAD)

Cancer Research
Abstract Background: TLS are recognized as significant biomarkers for patient prognosis and therapy selection. In current clinical practice, TLS are often detected by manual assessment of H&E slides, which has been associated with reproducibility issues.
Nadezhda Lukashevich, Daniil Dymov, Aleksandr Sarachakov, Sofya Kust, Anna Love, Ivan Valiev, Dmitry Ivchenkov, Alexander Bagaev, Viktor Svekolkin, Nikita Kotlov, Vladimir Kushnarev   +10 more
openaire   +1 more source