Results 201 to 210 of about 20,710 (238)

Gene duplication, translocation and molecular evolution of Dmrt1 and related sex-determining genes in anurans

Shinde SS, Veltsos P, Ma W.
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Genetic evidence equating SRY and the testis-determining factor

Nature, 1990
The testis-determining factor gene (TDF) lies on the Y chromosome and is responsible for initiating male sex determination. SRY is a gene located in the sex-determining region of the human and mouse Y chromosomes and has many of the properties expected for TDF.
P, Berta, J R, Hawkins, A H, Sinclair, A, Taylor, B L, Griffiths, P N, Goodfellow, M, Fellous   +6 more
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Genetic evidence that ZFY is not the testis-determining factor

Nature, 1989
In mammals, the testis determining gene (TDF), present on the Y chromosome, induces the undifferentiated gonads to form testes. The position of TDF on the human Y chromosome has been defined by analysing the genomes of XX males and XY females, generated by abnormal genetic exchange between the X and Y chromosomes in male meiosis.
M S, Palmer, A H, Sinclair, P, Berta, N A, Ellis, P N, Goodfellow, N E, Abbas, M, Fellous   +6 more
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Testis-determining factor and Y-linked sex reversal

Current Opinion in Genetics & Development, 1991
A gene named SRY, isolated last year from the sex-determining region of the human Y chromosome, satisfies many of the criteria expected of the testis-determining factor gene. Mutations in SRY have been found in XY females, strongly implicating SRY as the testis-determining gene.
Hawkins, J. Ross, Koopman, Peter, Berta, Philippe   +2 more
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Exclusion of SOX9 as the Testis Determining Factor in Ellobius lutescens: Evidence for Another Testis Determining Gene Besides SRY and SOX9

Molecular Genetics and Metabolism, 2001
In mammals the initiation of testis determination usually depends on the Y-chromosomal gene SRY. A few species, however, escape from this rule with a testis determination that is independent of SRY. The mole vole Ellobius lutescens is one of these species.
A, Baumstark, M, Akhverdyan, A, Schulze, I, Reisert, W, Vogel, W, Just   +5 more
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Detection of the Testis Determining Factor in an XX Man

Journal of Urology, 1993
An XX male patient was examined for the presence of 25 loci on the Y chromosome. Only 2 loci, the proximal border of the pseudoautosomal region Y and the sex determining region Y, were detected in this patient. The other 23 loci, including the zinc finger protein Y, were absent.
K, Fukutani, T, Kajiwara, S, Nagafuchi, Y, Nakahori, Y, Nakagome   +4 more
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Intercellular bridges and factors determining their patterns in the grasshopper testis

Journal of Morphology, 1988
AbstractIntercellular bridges joining cells contained in cysts of Chortophaga viridifasciata testes were studied with light and electron microscopy. Preparations consisted of expressed whole cells (living, or fixed and stained) as well as sections.
J G, Carlson, M A, Handel
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Pathology of 46, XY pure gonadal dysgenesis: absence of testis differentiation associated with mutations in the testis-determining factor

Differentiation, 1993
Individuals with 46, XY pure gonadal dysgenesis present with a completely female phenotype. These individuals develop bilateral streak gonads and have normal Müllerian structures. The apparent absence of testicular tissue in these individuals suggests a mutation in the initial steps of the male sex-determining pathway.
E, Vilain, F, Jaubert, M, Fellous, K, McElreavey   +3 more
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NMR Spectroscopic Analysis of the DNA Conformation Induced by the Human Testis Determining Factor SRY

Biochemistry, 1995
The conformation of an eight base pair DNA oligonucleotide duplex bound to the human testis determining factor SRY and the orientation of the protein domain within the complex have been analyzed by a variety of NMR methods which permit the selective observation of protons attached to 12C nuclei in the presence of uniformly enriched 13C/15N protein ...
Werner, M H, Bianchi, M E, Gronenborn, A M, Clore, G M   +3 more
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The human testis determining factor SRY: A new member of the HMG box protein family

Biochimie, 1994
The product of the sex-determining gene SRY is a member of the HMG box containing protein superfamily. The HMG box is a DNA-binding domain of about 80 amino acids shared by many proteins with diverse functions. It seems that the functions of the full length protein are restricted to the HMG box but their molecular basis remains to be determined.
S, Soullier, F, Poulat, B, Boizet-Bonhoure, B, Calas, R, Bennes, F, Heitz, P, Berta   +6 more
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