Results 211 to 220 of about 20,710 (238)

Human Testis-Determining Factor SRY Binds to the Major DNA Adduct of Cisplatin and a Putative Target Sequence with Comparable Affinities

Biochemistry, 1998
cis-Diamminedichloroplatinum(II) (cis-DDP or cisplatin) is a widely used anticancer drug that is most effective against tumors of the testis. Although cisplatin is believed to mediate its cytotoxicity through the formation of DNA adducts, the precise biochemical mechanisms underlying its antitumor activity and selectivity for testicular tumors remain ...
E E, Trimmer, D B, Zamble, S J, Lippard, J M, Essigmann   +3 more
openaire   +2 more sources

[Localization of human testis determining factors on Y chromosome].

Zhonghua yi xue za zhi, 1991
This is a study of in situ chromosomal hybridization and dot blot and southern blot hybridization using a testis determining factor related probe Y156 in sexually malformed patients. According to the phenotype karyotype analysis and hybridization results of these cases, especially 2 cases with dic (Y) and different breakpoints, we consider that the TDF
openaire   +1 more source

The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues.

American journal of human genetics, 1990
The zinc-finger-Y (ZFY) gene is a candidate for the testis-determining-factor gene (TDF) on the human Y chromosome and is postulated to initiate testis differentiation during embryogenesis. However, the present study indicates that the ZFY gene and its X homologue (ZFX) are differentially expressed in adult tissues. A human testis-specific ZFY cDNA was
Y F, Lau, K M, Chan
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The molecular action of testis-determining factors SRY and SOX9.

Novartis Foundation symposium, 2002
Despite 10 years of work since the discovery of SRY, little is known about its biochemical function. The HMG domain, a DNA-binding and DNA-bending motif, plays a central role, being the only region conserved between species and the site of almost all clinical mutations causing XY gonadal dysgenesis.
openaire   +1 more source

The elusive testis-determining factor

Trends in Genetics, 1985
J. Wolfe, P.N. Goodfellow
openaire   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

The search for the mammalian testis-determining factor is on again

Reproduction, Fertility and Development, 1990
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Testis Determining Factor

2012
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Testis Determining Factor

2018
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TDF (testis determining factor)

2008
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