Results 41 to 50 of about 183,045 (246)
Estrogen Alleviates Sevoflurane‐Induced Neurotoxicity by Inhibiting ERα‐Tau Binding
Advanced Science, EarlyView.Sevoflurane‐induced neurotoxicity exhibits sex differences, and estrogen can mitigate these effects; however, its protective action appears to be time‐window dependent, which may be related to the competitive binding of estrogen and Tau to ERα. Abstract Sevoflurane‐induced neurotoxicity is age‐dependent, but the role of sex differences is unclear ...
Feixiang Li +8 more
wiley +1 more source
Arquivos de Gastroenterologia, 2014 Context Hypogonadism is a common clinical situation in male patients with liver cirrhosis. Objectives The aim of the present study was to evaluate the effects of orthotopic liver transplantation on testosterone, free testosterone and sex hormone ...
Rodrigo NITSCHE +4 more
doaj +1 more source
Advanced Science, EarlyView.Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei +8 more
wiley +1 more source
Genetic determinants of serum testosterone concentrations in men.
PLoS Genetics, 2011 Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity.
Claes Ohlsson +59 more
doaj +1 more source
Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids
Advanced Science, EarlyView.To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun +9 more
wiley +1 more source
Safety and efficacy of testosterone gel in the treatment of male hypogonadism
Clinical Interventions in Aging, 2009 Kishore M Lakshman, Shehzad BasariaSection of Endocrinology, Diabetes, and Nutrition. Boston University School of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Transdermal testosterone gels were first introduced in the US in 2000. Since then,
Kishore M Lakshman, Shehzad Basaria
doaj
Advanced Science, EarlyView.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source
Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Cancer Cells
International Journal of Endocrinology, 2016 Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action.
Huika Li +8 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2016 Testosterone is an important sex hormone and mediates reproduction in male vertebrates. There is ample evidence that testosterone coordinates the expression of physiological, morphological and behavioural traits during reproduction and many of these ...
Beate Apfelbeck +3 more
doaj +1 more source
A systematic review of transgender male rodent model methodology
Animal Models and Experimental Medicine, EarlyView.Summary of successful transgender male rodent model methods. Testosterone enanthate or cypionate injected SC or IM once per week at 18 mg/kg in mice or 3 mg/kg in rats should effectively match naive male testosterone levels of their respective species.
Kai Robertson +4 more
wiley +1 more source