Results 31 to 40 of about 472,621 (287)

Mosaic tetracycline resistance genes encoding ribosomal protection proteins [PDF]

, 2016
First reported in 2003, mosaic tetracycline resistance genes are a subgroup of the genes encoding ribosomal protection proteins (RPPs). They are formed when two or more RPP-encoding genes recombine resulting in a functional chimera. To date, the majority
Adam P. Roberts, Dewey, Levy, Nina Amodeo, Philip J. Warburton, Rajić   +5 more
core   +3 more sources

Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells

OncoImmunology, 2019
We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T cells
Ahdab Alsaieedi, Angelika Holler, Pedro Velica, Gavin Bendle, Hans J. Stauss   +4 more
doaj   +1 more source

Detection of a new tet(X6)-encoding plasmid in Acinetobacter towneri

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The aim of this study was to characterise a novel tet(X6)-carrying plasmid detected in a livestock-associated Acinetobacter towneri isolate.
Yingying Cheng, Yong Chen, Yang Liu, Jingjie Song, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou   +7 more
doaj   +1 more source

Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene tet(X)-Bearing Plasmidome among Bacteria

mSystems, 2020
The emergence of novel plasmid-mediated resistance genes constitutes a great public concern. Recently, mobile tet(X) variants were reported in diverse pathogens from different sources.
Ruichao Li, Xiaoyu Lu, Kai Peng, Ziyi Liu, Yan Li, Yuan Liu, Xia Xiao, Zhiqiang Wang   +7 more
doaj   +1 more source

Two Different Tetracycline Resistance Mechanisms, Plasmid-Carried tet(L) and Chromosomally Located Transposon-Associated tet(M), Coexist in Lactobacillus sakei Rits 9 [PDF]

, 2008
Lactobacillus sakei is extensively used as functional starter culture in fermented meat products. One of the safety criteria of a starter culture is the absence of potentially transferable antibiotic resistance determinants.
Ammor, M.S., Gueimonde, M., Danielsen, M., Zagorec, M., Hoek, A.H.A.M., van, Reyes-Gavilán, C.G., de los, Mayo, B., Margolles, A.   +7 more
core   +2 more sources

Prevalence and risk factors of tet(X4)-positive Enterobacteriaceae in human gut microbiota

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This work is aimed to investigate the prevalence of tet(X4) in healthy individuals and patients and assess risk factors associated with tet(X4)-positive populations.
Yu Zeng, Li Deng, Xianyuan Zhou, Chi Zhang, Zhen Hu, Yunsheng Chen, Weidong Zheng   +6 more
doaj   +1 more source

Acute loss of TET function results in aggressive myeloid cancer in mice [PDF]

, 2015
TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer.
A Ciccia, A Klinakis, A Mayle, A Sanjuan-Pla, A Tsagaratou, A Wilson, AM Deaton, C Quivoron, CG Spruijt, D Hanahan, D Lara-Astiaso, D Schubeler, F Delhommeau, F Lemonnier, GA Challen, GC Hon, H Celik, H Ji, H Wu, J Adolfsson, J Cheng, J Kang, J Riddell, JL Christensen, K Moran-Crusio, L Cimmino, L Cimmino, L Couronne, L Dang, L Laurent, L Shen, L Wang, M Bachman, M Hu, M Jeong, M Ko, M Ko, M Ko, M Tahiliani, MA Goodell, MA Inlay, MJ Kiel, NB Ivanova, NC Boles, O Abdel-Wahab, O Odejide, R Kuhn, S Ito, SC Kogan, SJ Song, SJ Song, SM Chambers, SY Ng, T Baubec, T Nakagawa, TH Bestor, W Xu, WA Pastor, Y Huang, Y Huang, Y Huang, Y Zhang, YF He, YH Kim, Z Li   +64 more
core   +1 more source

Tet repressor binding induced curvature of tet operator DNA

Nucleic Acids Research, 1989
Tet repressor dimer binds to two tet operator sites spaced by 30 bp in the Tn10 encoded tet regulatory DNA. The effect of repressor binding on the gel mobility of circular permutated DNA fragments containing either one or both operator sequences is reported.
K, Tovar, W, Hillen
openaire   +3 more sources

Characterizing the removal of antibiotics in algal wastewater treatment ponds : a case study on tetracycline in HRAPs: a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Environmental Engineering at Massey University, Turitea Campus, Palmerston, New Zealand [PDF]

, 2016
Antibiotics are ubiquitous pollutants in wastewater, owing to their usefulness in both animal and human treatment. Antibiotic pollution is a growing concern because of the risk of encouraging antibiotic resistance in wastewater treatment (WWT) systems ...
Norvill, Zane
core  

Tet-On Systems For Doxycycline-inducible Gene Expression. [PDF]

, 2016
The tetracycline-controlled Tet-Off and Tet-On gene expression systems are used to regulate the activity of genes in eukaryotic cells in diverse settings, varying from basic biological research to biotechnology and gene therapy applications.
Berkhout, B., Das, A.T., Tenenbaum, L.
core   +2 more sources