Results 51 to 60 of about 305,776 (233)

A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria

EBioMedicine, 2022
Summary: Background: Tigecycline is one of the few last-resort antibiotics for the treatment of carbapenem-resistant Enterobacteriaceae infection, the incidence of which has been rapidly increasing.
Lei Xu, Yonglin Zhou, Sen Niu, Zhiying Liu, Yinuo Zou, Yanan Yang, Haihua Feng, Dejun Liu, Xiaodi Niu, Xuming Deng, Yang Wang, Jianfeng Wang   +11 more
doaj   +1 more source

DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver disorders among adults, children, and adolescents, and a growing epidemic, worldwide.
Besaratinia, Ahmad, Tommasi, Stella
core   +1 more source

Source tracking and global distribution of the mobilized tigecycline resistant gene tet(X) [PDF]

, 2021
AbstractThe emergence of tet(X) genes has compromised the clinical use of the last-line antibiotic tigecycline. We identified 322 (1.21%) tet(X) positive samples from 12,829 human microbiome samples distributed in four continents (Asia, Europe, North America and South America) using retrospective data from worldwide.
Rong-min Zhang, Jian Sun, Ruan-yang Sun, Min-ge Wang, Chao-yue Cui, Liang-xing Fang, Mei-na Liao, Xiao-qing Lu, Yong-xin Liu, Xiao-Ping Liao, Ya-Hong Liu   +10 more
openaire   +1 more source

Emergence of mobile tigecycline resistance gene tet(X4)-harbouring Shewanella xiamenensis in a water environment

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Tigecycline resistance mediated by the mobile tigecycline-inactivating enzyme gene tet(X) in Gram-negative bacteria is an emerging concern for global public health. However, limited information is available on the distribution of tet(X) in
Trung Duc Dao, Ikuro Kasuga, Aki Hirabayashi, Dong Tu Nguyen, Hien Thi Tran, Hieu Vu, Linh Tuyet Ngoc Pham, Thi My Hanh Vu, Futoshi Hasebe, Ha Thanh Nguyen, Trang Le Thi, Hoang Huy Tran, Keigo Shibayama, Taichiro Takemura, Masato Suzuki   +14 more
doaj   +1 more source

Identification of novel Tet(X6)-Tet(X2) recombinant variant in Elizabethkingia meningoseptica from a bullfrog farm and downstream river in China

Frontiers in Microbiology
IntroductionThe dissemination of strains producing tetracyclines monooxygenase Tet(X) from breeding farms to the natural environment poses a potential threat to public health.MethodsAntimicrobial susceptibility testing and WGS were performed to identify ...
Haobo Jin, Qing Jia, Xi Jin, Xinlong Zhu, Min-Ge Wang, Ruan-Yang Sun, Chaoyue Cui   +6 more
doaj   +1 more source

Electron correlation in FeSe superconductor studied by bulk-sensitive photoemission spectroscopy

, 2010
We have investigated the electronic structures of recently discovered superconductor FeSe by soft-x-ray and hard-x-ray photoemission spectroscopy with high bulk sensitivity.
A. Higashiya, A. Sekiyama, A. Sekiyama, A. Sugimura, A. Yamasaki, H. Azuma, H. Kobori, H. Sato, K. Takase, K. Tamasaku, K. Terashima, M. Yabashi, N. Miyagawa, N. Umeyama, S. I. Ikeda, S. Imada, S. Suga, T. Ishikawa, T. Muro, Y. Hara, Y. Kato, Y. Matsui   +21 more
core   +1 more source

Functional analysis of the Arabidopsis TETRASPANIN gene family in plant growth and development [PDF]

, 2015
TETRASPANIN (TET) genes encode conserved integral membrane proteins that are known in animals to function in cellular communication during gamete fusion, immunity reaction and pathogen recognition.
Himanen, Kristiina, Muto, Antonella, Neyt, Pia, Van de Velde, Jan, Van Lijsebettens, Maria, Vandepoele, Klaas, Wang, Feng   +6 more
core   +1 more source

Presence of Mobile Tigecycline Resistance Gene tet(X4) in Clinical Klebsiella pneumoniae

Microbiology Spectrum, 2022
The recently emerged plasmid-mediated tigecycline resistance gene tet(X4) has mainly been detected in Escherichia coli but never in Klebsiella pneumoniae. Herein, we identified a clinical K.
Weishuai Zhai, Yingxin Tian, Mi Lu, Muchen Zhang, Huangwei Song, Yulin Fu, Tengfei Ma, Chengtao Sun, Li Bai, Yang Wang, Dejun Liu, Ying Zhang   +11 more
doaj   +1 more source

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme [PDF]

, 2015
5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression ...
CAIAFA, Paola, CICCARONE, FABIO, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +3 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source