Results 31 to 40 of about 54,144 (166)

Concurrence of Inactivation Enzyme-Encoding Genes tet(X), bla_EBR, and estT in Empedobacter Species from Chickens and Surrounding Environments [PDF]

Foods
The emergence of inactivation enzyme-encoding genes tet(X), blaEBR, and estT challenges the effectiveness of tetracyclines, β-lactams, and macrolides.
Chong Chen, Yilin Lv, Taotao Wu, Jing Liu, Yanan Guo, Jinlin Huang   +5 more
doaj   +2 more sources

A rapid liquid chromatography-tandem mass spectrometry based method for the detection of Tet(X) resistance gene in Enterobacteriaceae [PDF]

Frontiers in Microbiology
There is a major public health threat posed by antibiotic resistance around the world. Tigecycline overcomes the resistance mechanisms of traditional tetracyclines and is often seen as the final resort in combating infections caused by bacteria resistant
Liyun Zhang, Jie Xie, Ziyu Qu, Duan Duan, Chujun Liu, Chujun Liu, Di Zhang, Haiyang Jiang, Xinhua Dai, You Jiang, Xiang Fang, Congming Wu   +11 more
doaj   +2 more sources

Identification of novel tetracycline resistance gene tet (X14) and its co-occurrence with tet (X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris

Emerging Microbes and Infections, 2020
Tigecycline is one of the last-resort antibiotics to treat severe infections. Recently, tigecycline resistance has sporadically emerged with an increasing trend, and Tet(X) family represents a new resistance mechanism of tigecycline.
Yingying Cheng, Yong Chen, Hao Xu
exaly   +3 more sources

A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria

EBioMedicine, 2022
Summary: Background: Tigecycline is one of the few last-resort antibiotics for the treatment of carbapenem-resistant Enterobacteriaceae infection, the incidence of which has been rapidly increasing.
Lei Xu, Yonglin Zhou, Sen Niu
exaly   +3 more sources

Unraveling the evolution and global transmission of high level tigecycline resistance gene tet(X)

Environment International
An increasing number of tet(X) variants conferring tigecycline resistance have been reported, posing a threat to clinical treatment of multi-drug resistance bacteria as tigecycline serves as the last-resort antibiotic. In this study, a total of 721 tet(X)
Chaoqun Yao, Longyang Jin, Qi Wang, Meng Wang, Ruobing Wang, Meng Cai, Kaiwen Song, Hui Wang   +7 more
doaj   +3 more sources

Novel ST3871 Escherichia coli exhibits diverse transmission modes, carrying the tet(X4) resistance gene [PDF]

Microbiology Spectrum
Although tigecycline is strictly restricted for use in animals, plasmid-mediated tet(X) is increasingly being detected in swine and poultry production, which may be associated with the highly intensive farming model and the use of antibiotics as feed ...
Qing Wang, Chengye Wang, Muhammad Shoaib, Xiaohui Yao, Xi Chen, Yanhua Qiu, Guonian Dai, Honglin Lin, Weiwei Wang, Jiyu Zhang   +9 more
doaj   +2 more sources

Evidence that SmTetX is not a tetracycline resistance determinant [PDF]

Microbiology Spectrum
SmTetX, a flavin-dependent monooxygenase from the opportunistic pathogen Stenotrophomonas maltophilia, is structurally related to the tetracycline-degrading Tet(X) resistance enzymes, though displays substantial divergence in active site residues.
Matthew J. Beech, Maria M. Trush, Edmond C. Toma, Alistair J. M. Farley, Timothy R. Walsh, Christopher J. Schofield   +5 more
doaj   +2 more sources

Prevalence and characterization of an integrative and conjugative element carrying tet(X) gene in Elizabethkingia meningoseptica

Journal of Global Antimicrobial Resistance
Objectives: To investigate the tet(X) gene, a determinant of tigecycline resistance, in the emerging pathogen Elizabethkingia meningoseptica and its association with an integrative and conjugative element (ICE). Methods: All E.
Sérgio M. Morgado, Érica L. Fonseca, Ana Carolina P. Vicente   +2 more
doaj   +3 more sources

Acquisition and Spread of Antimicrobial Resistance: A tet(X) Case Study. [PDF]

Int J Mol Sci, 2021
Understanding the mechanisms leading to the rise and dissemination of antimicrobial resistance (AMR) is crucially important for the preservation of power of antimicrobials and controlling infectious diseases. Measures to monitor and detect AMR, however, have been significantly delayed and introduced much later after the beginning of industrial ...
Aminov R.
europepmc   +5 more sources

Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X). [PDF]

Microbiol Spectr, 2021
The emergence of the tigecycline resistance gene tet (X) has posed a severe threat to public health. However, reports of its origin and distribution in human remain rare.
Zhang RM, Sun J, Sun RY, Wang MG, Cui CY, Fang LX, Liao MN, Lu XQ, Liu YX, Liao XP, Liu YH.   +10 more
europepmc   +4 more sources