Harnessing efficient multiplex PCR methods to detect the expanding Tet(X) family of tigecycline resistance genes [PDF]
Virulence, 2020 A growing number of tet(X)-type tigecycline resistance determinants [tet(X1) to tet(X5)] constitutes an expanding family of tetracycline-inactivating enzymes, posing a potential risk to global public health.
Yongchang Xu, Man Huang, Xu Jia
exaly +6 more sources
Classification and molecular characteristics of tet(X)-carrying plasmids in Acinetobacter species [PDF]
Frontiers in Microbiology, 2022 The rapid dissemination of plasmid-mediated tet(X) genes in Acinetobacter species has compromised the clinical effectiveness of tigecycline, one of the last-resort antibiotics.
Chong Chen +13 more
doaj +4 more sources
MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria [PDF]
Virulence, 2022 The extensive use of tetracycline antibiotics has led to the widespread presence of tetracycline-resistance genes in Gram-negative bacteria and this poses serious threats to human and animal health.
Zi-Jian Zheng +14 more
doaj +5 more sources
Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria [PDF]
Microbiology Spectrum, 2022 Antibiotic resistance has caused a serious threat to public health and human safety. Recently, the emergence of novel resistance gene tet(X4) and its variants threatens the clinical utility of tigecycline, one of the last-line antibiotics for multidrug ...
Tian Deng +5 more
doaj +4 more sources
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species [PDF]
Genome Medicine, 2020 Background The recent emergence and dissemination of high-level mobile tigecycline resistance Tet(X) challenge the clinical effectiveness of tigecycline, one of the last-resort therapeutic options for complicated infections caused by multidrug-resistant ...
Chong Chen +22 more
doaj +5 more sources
Occurrence and Molecular Characterization of Abundant tet(X) Variants Among Diverse Bacterial Species of Chicken Origin in Jiangsu, China [PDF]
Frontiers in Microbiology, 2021 Many novel tigecycline-inactivating enzymes encoded by tet(X) variants from different bacteria were discovered since the plasmid-mediated tet(X3) and tet(X4) genes conferring high-level resistance to tigecycline in Enterobacterales and Acinetobacter were
Kai Peng, Xinran Sun, Ruichao Li
exaly +4 more sources
Chlorogenic acid attenuates tet (X)-mediated doxycycline resistance of Riemerella anatipestifer [PDF]
Frontiers in Veterinary ScienceIntroductionThe increasing resistance of R. anatipestifer has posed a significant threat to the poultry industry in recent years. The tet gene is the primary determinant of tetracycline resistance in numerous bacteria, and the enzyme modification gene ...
Yuwen Han +6 more
doaj +4 more sources
Genomic Diversity of the tet(X)-Positive Myroides Species [PDF]
MicroorganismsThe rapid spread of tet(X) genes capable of inactivating tigecycline represents a critical challenge to global public health. This study aims to explore the distribution, genetic diversity, and transferability of tet(X) genes in Myroides, a genus of Gram-
Chong Chen +3 more
doaj +4 more sources
Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations [PDF]
Frontiers in MicrobiologyIntroductionThe emergence of the wide variety of novel tigecycline resistance tet(X) variants, including tet(X3), tet(X4), tet(X5), and tet(X6), has raised a serious threat to global public health and posed a significant challenge to the clinical ...
Juan Liu +22 more
doaj +4 more sources
Rapid and Accurate Antibiotic Susceptibility Determination of tet(X)-Positive E. coli Using RNA Biomarkers [PDF]
Microbiology Spectrum, 2021 The emergence and prevalence of novel plasmid-mediated tigecycline resistance genes, namely, tet(X) and their variants, pose a serious threat to public health worldwide.
Haijie Zhang +7 more
doaj +4 more sources