Results 21 to 30 of about 54,144 (166)

Establishment of Specific Multiplex PCR Detection Methods for the Predominant tet(X)-Positive Acinetobacter Species [PDF]

Microorganisms
The increasing prevalence of the mobile tigecycline resistance gene tet(X) poses a severe global health threat, and the genus Acinetobacter is a major reservoir.
Chong Chen, Jing Liu, Jie Gao, Taotao Wu, Jinlin Huang   +4 more
doaj   +5 more sources

Coexistence of blaOXA-58 and tet(X) on a Novel Plasmid in Acinetobacter sp. From Pig in Shanghai, China [PDF]

Frontiers in Microbiology, 2020
The purpose of this study was to characterize the complete sequence of a novel plasmid carrying tigecycline resistance gene tet(X) and carbapenemase gene blaOXA-58 from a swine Acinetobacter sp. strain SH19PTT10.
Jing Wang, Jing Wang, Yan Wang, Yan Wang, Han Wu, Han Wu, Zhen-Yu Wang, Zhen-Yu Wang, Peng-Cheng Shen, Peng-Cheng Shen, Yu-Qi Tian, Yu-Qi Tian, Fan Sun, Fan Sun, Zhi-Ming Pan, Zhi-Ming Pan, Xinan Jiao, Xinan Jiao   +17 more
doaj   +5 more sources

Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X) [PDF]

Nature Communications, 2020
Emergence of tigecycline-resistance tet(X) genes is of concern. Here, the authors determine tet(X) prevalence in more than 6,000 clinical Gram-negative bacterial isolates collected between 1994 to 2019 in hospitals in China and suggest that ...
Rong Zhang, Ning Dong, Zhangqi Shen, Yu Zeng, Jiauyue Lu, Congcong Liu, Hongwei Zhou, Yanyan Hu, Qiaoling Sun, Qipeng Cheng, Lingbing Shu, Jiachang Cai, Edward Wai-Chi Chan, Gongxiang Chen, Sheng Chen   +14 more
doaj   +6 more sources

Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance [PDF]

MSystems, 2021
The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the clinical efficacy of tigecycline as a last-resort antibiotic to treat multidrug-resistant (MDR) Gram ...
Chao-Yue Cui, Cang Li, Chong Chen
exaly   +5 more sources

Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China [PDF]

Frontiers in Microbiology, 2018
To investigate tetracycline resistance and resistant genotype in Riemerella anatipestifer, the tetracycline susceptibility of 212 R. anatipestifer isolates from China between 2011 and 2017 was tested.
De-Kang Zhu, De-Kang Zhu, Hong-Yan Luo, Hong-Yan Luo, Ma-Feng Liu, Ma-Feng Liu, Xin-Xin Zhao, Xin-Xin Zhao, Ren-Yong Jia, Ren-Yong Jia, Shun Chen, Shun Chen, Kun-Feng Sun, Kun-Feng Sun, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Xiao-Yue Chen, Xiao-Yue Chen, An-Chun Cheng, An-Chun Cheng, Ming-Shu Wang, Ming-Shu Wang   +23 more
doaj   +3 more sources

Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet (X)

Microbiology Spectrum, 2021
The emergence of tet(X) genes has compromised the clinical use of the last-line antibiotic tigecycline. We identified 322 (1.21%) tet(X) positive samples from 12,829 human microbiome samples distributed in four continents (Asia, Europe, North America ...
Min-Ge Wang, Chao-Yue Cui, Yong-Xin Liu   +2 more
exaly   +3 more sources

A method for screening tigecycline-resistant gene tet(X) from human gut

Journal of Global Antimicrobial Resistance, 2021
Objectives: To develop an effective enrichment method for tet(X) detection, we performed PCR and Sanger sequencing to screen and confirm the presence of tet(X) gene. Methods: Species were identified by MALDI-TOF MS analysis.
Yu Zeng, Jiayue Lu, Congcong Liu, Zhuoren Ling, Qiaoling Sun, Hanyu Wang, Hongwei Zhou, Yanyan Hu, Gongxiang Chen, Rong Zhang   +9 more
doaj   +3 more sources

Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene tet(X)-Bearing Plasmidome among Bacteria [PDF]

mSystems, 2020
The emergence of novel plasmid-mediated resistance genes constitutes a great public concern. Recently, mobile tet(X) variants were reported in diverse pathogens from different sources.
Ruichao Li, Xiaoyu Lu, Kai Peng, Ziyi Liu, Yan Li, Yuan Liu, Xia Xiao, Zhiqiang Wang   +7 more
doaj   +2 more sources

Genetic Characterization of the Tetracycline-Resistance Gene tet(X) Carried by Two Epilithonimonas Strains Isolated from Farmed Diseased Rainbow Trout, Oncorhynchus mykiss in Chile [PDF]

Antibiotics, 2021
The main objective of this study was to characterize the tet(X) genes, which encode a monooxygenase that catalyzes the degradation of tetracycline antibiotics, carried by the resistant strains FP105 and FP233-J200, using whole-genome sequencing analysis.
Christopher Concha, Claudio D. Miranda, Javier Santander, Marilyn C. Roberts   +3 more
doaj   +2 more sources

Rapid Detection of High-Level Tigecycline Resistance in Tet(X)-Producing Escherichia coli and Acinetobacter spp. Based on MALDI-TOF MS [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
The emergence and spread of the novel mobile Tet(X) tetracycline destructases confer high-level tigecycline and eravacycline resistance in Escherichia coli and Acinetobacter spp. and pose serious threats to human and animal health. Therefore, a rapid and
Ze-Hua Cui, Ze-Hua Cui, Zi-Jian Zheng, Zi-Jian Zheng, Tian Tang, Tian Tang, Zi-Xing Zhong, Zi-Xing Zhong, Chao-Yue Cui, Chao-Yue Cui, Xin-Lei Lian, Xin-Lei Lian, Liang-Xing Fang, Liang-Xing Fang, Qian He, Qian He, Xi-Ran Wang, Xi-Ran Wang, Chong Chen, Chong Chen, Bing He, Bing He, Min-Ge Wang, Min-Ge Wang, Ya-Hong Liu, Ya-Hong Liu, Ya-Hong Liu, Xiao-Ping Liao, Xiao-Ping Liao, Xiao-Ping Liao, Jian Sun, Jian Sun, Jian Sun   +32 more
doaj   +2 more sources