Erratum for Zhang et al., "Source Tracking and Global Distribution of the Tigecycline-Nonsusceptible Tet(X)". [PDF]
Microbiol Spectr, 2022 Zhang RM +10 more
europepmc +4 more sources
Threat and Control of <i>tet</i>(X)-Mediated Tigecycline-Resistant <i>Acinetobacter</i> sp. Bacteria. [PDF]
FoodsTigecycline is regarded as one of the last-resort antibiotics against multidrug-resistant (MDR) Acinetobacter sp. bacteria. Recently, the tigecycline-resistant Acinetobacter sp. isolates mediated by tet(X) genes have emerged as a class of global pathogens for humans and food-producing animals. However, the genetic diversities and treatment options were
Chen C, Wu T, Liu J, Gao J.
europepmc +3 more sources
Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance. [PDF]
Chem SciA fluorescence polarisation binding assay for Tet(X), an emerging tetracycline antibiotic resistance mechanism, was developed. Application of the assay resulted in the discovery of inhibitors with novel binding modes.
Beech MJ +13 more
europepmc +3 more sources
Evolution in action: dissemination of tet(X) into pathogenic microbiota. [PDF]
Front Microbiol, 2013 In a recent publication by Leski et al. (2013), the authors reported the occurrence of multidrug-resistant tet(X)-containing bacterial strains in a hospital in Sierra Leone. Among 52 clinical isolates, 11 (21%) have been confirmed tet(X)-positive. All the positive strains have been isolated from urinary tract infections and identified as Enterobacter ...
Aminov RI.
europepmc +5 more sources
Emergence of a novel high-level tigecycline resistance gene <i>tet</i>(X6) variant coexisting with <i>tet</i>(X2) and two <i>tet</i>(X) copies in a <i>Sphingobacterium</i> sp. [PDF]
Antimicrob Agents ChemotherXu Q +7 more
europepmc +3 more sources
Broad-host-range IncW plasmid harbouring tet(X) in Escherichia coli isolated from pigs in Japan
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Tetracyclines are used in veterinary medicine for livestock. Tigecycline, a semisynthetic tetracycline derivative, is a last-resort antimicrobial used to treat multidrug-resistant Gram-negative bacterial infections.
Masaru Usui +4 more
doaj +1 more source
Microbiology Spectrum, 2021 The emergence of high-level tigecycline resistance mediated by plasmid-borne tet(X) genes greatly threatens the clinical effectiveness of tigecycline. However, the dissemination pattern of plasmid-borne tet(X) genes remains unclear. We here recovered tet(
Ying-Ying Cheng +6 more
doaj +1 more source
Advances in mechanism study on novel tetracycline-inactivating enzymes tet(X) causing emerging tigecycline resistance [PDF]
Zhenduanxue lilun yu shijian, 2023 Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next-generation tetracycline that is the final line of defense against severe infections by carbapenem-resistant Gram-negative bacteria.
SHEN Pinghua, CHEN Huifen
doaj +1 more source
Co-occurrence of two tet(X) variants in an Empedobacter brevis of shrimp origin. [PDF]
Antimicrob Agents Chemother, 2019 Emerging novel resistance mechanisms pose a great public health concern.….
Li R +5 more
europepmc +4 more sources
Anti-HIV agent azidothymidine decreases Tet(X)-mediated bacterial resistance to tigecycline in Escherichia coli. [PDF]
Commun Biol, 2020 AbstractRecent emergence of high-level tigecycline resistance mediated by Tet(X3/X4) in Enterobacteriaceae undoubtably constitutes a serious threat for public health worldwide. Antibiotic adjuvant strategy makes antibiotic more effective against these resistant pathogens through interfering intrinsic resistance mechanisms or enhancing antibiotic ...
Liu Y +5 more
europepmc +4 more sources