Results 51 to 60 of about 54,144 (166)

Detection of a new tet(X6)-encoding plasmid in Acinetobacter towneri

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The aim of this study was to characterise a novel tet(X6)-carrying plasmid detected in a livestock-associated Acinetobacter towneri isolate.
Yingying Cheng, Yong Chen, Yang Liu, Jingjie Song, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou   +7 more
doaj   +1 more source

Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China

Microbiology Spectrum, 2021
We isolated eight tigecycline-resistant Enterobacteriaceae strains from a pig farm in Shanghai, China, including Escherichia coli (n = 1), Proteus cibarius (n = 1), and Enterobacter hormaechei (n = 6). Two of them (E. coli and P.
Jing Wang, Han Wu, Cai-Yue Mei, Yan Wang, Zhen-Yu Wang, Meng-Jun Lu, Zhi-Ming Pan, Xinan Jiao   +7 more
doaj   +1 more source

Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli. [PDF]

Nat Microbiol, 2019
Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and ribosome protection2,3.
Sun J, Chen C, Cui CY, Zhang Y, Liu X, Cui ZH, Ma XY, Feng Y, Fang LX, Lian XL, Zhang RM, Tang YZ, Zhang KX, Liu HM, Zhuang ZH, Zhou SD, Lv JN, Du H, Huang B, Yu FY, Mathema B, Kreiswirth BN, Liao XP, Chen L, Liu YH.   +24 more
europepmc   +4 more sources

Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone [PDF]

International Journal of Antimicrobial Agents, 2013
The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a molecular epidemiological study was ...
Leski, Tomasz A, Bangura, Umaru, Jimmy, David Henry, Ansumana, Rashid, Lizewski, Stephen E, Stenger, David A, Taitt, Chris Rowe, Vora, Gary J   +7 more
openaire   +2 more sources

Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4)

Frontiers in Microbiology, 2022
With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise, and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants. The new tetracycline-class antibiotic, tigecycline is the last resort
Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Jinfeng Wen, Yuwei Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Anchun Cheng, Anchun Cheng, Anchun Cheng   +48 more
doaj   +1 more source

Emergence of tigecycline-resistant <i>Raoultella ornithinolytica</i> with <i>tet</i>(X)-carrying plasmid from swine wastewater in China. [PDF]

Front Microbiol
BackgroundThe increasing prevalence of antibiotic resistance genes (ARGs), such as the plasmid-mediated tigecycline-modifying enzyme tet(X), significantly hinders the treatment of infectious diseases in humans and animals. Livestock wastewater contributes to the transmission of these ARGs.MethodsBetween June 2023 and December 2024, 140 wastewater ...
Jia Q, Jin H, Jin X, Zhu X, Cui C.
europepmc   +3 more sources

An Outbreak of tet(X6)-Carrying Tigecycline-Resistant Acinetobacter baumannii Isolates with a New Capsular Type at a Hospital in Taiwan

Antibiotics, 2021
Dissemination of multidrug-resistant, particularly tigecycline-resistant, Acinetobacter baumannii is of critical importance, as tigecycline is considered a last-line antibiotic.
Yu-Chia Hsieh, Jia-Wen Wu, Yi-Yin Chen, Tran Lam Tu Quyen, Wei-Chao Liao, Shiao-Wen Li, Yin-Cheng Chen, Yi-Jiun Pan   +7 more
doaj   +1 more source

Preliminary view of the global distribution and spread of the tet(X) family of tigecycline resistance genes

Journal of Antimicrobial Chemotherapy, 2020
Abstract Background The emergence of plasmid-mediated tet(X3)/tet(X4) genes is threatening the role of tigecycline as a last-resort antibiotic to treat clinical infections caused by XDR bacteria. Considering the possible public health threat posed by tet(X) and its variants [which we collectively call
Yu, Pan, Furqan, Awan, Ma, Zhenbao, Xiufeng, Zhang, Jiaxiong, Zeng, Zhenling, Zeng, Wenguang, Xiong   +6 more
openaire   +2 more sources

Identification of novel Tet(X6)-Tet(X2) recombinant variant in Elizabethkingia meningoseptica from a bullfrog farm and downstream river in China

Frontiers in Microbiology
IntroductionThe dissemination of strains producing tetracyclines monooxygenase Tet(X) from breeding farms to the natural environment poses a potential threat to public health.MethodsAntimicrobial susceptibility testing and WGS were performed to identify ...
Haobo Jin, Qing Jia, Xi Jin, Xinlong Zhu, Min-Ge Wang, Ruan-Yang Sun, Chaoyue Cui   +6 more
doaj   +1 more source

Emergence of mobile tigecycline resistance gene tet(X4)-harbouring Shewanella xiamenensis in a water environment

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Tigecycline resistance mediated by the mobile tigecycline-inactivating enzyme gene tet(X) in Gram-negative bacteria is an emerging concern for global public health. However, limited information is available on the distribution of tet(X) in
Trung Duc Dao, Ikuro Kasuga, Aki Hirabayashi, Dong Tu Nguyen, Hien Thi Tran, Hieu Vu, Linh Tuyet Ngoc Pham, Thi My Hanh Vu, Futoshi Hasebe, Ha Thanh Nguyen, Trang Le Thi, Hoang Huy Tran, Keigo Shibayama, Taichiro Takemura, Masato Suzuki   +14 more
doaj   +1 more source